Aseptic meningitis and abducens nerve palsy as a serious side effect of high dose intravenous immunoglobulin used in a patient with renal transplantation

S. E. Wright; Z. H A Shaikh; J. A. Castillo-Lugo; B. Tanriover

doi:10.1111/j.1399-3062.2007.00294.x

Aseptic meningitis and abducens nerve palsy as a serious side effect of high dose intravenous immunoglobulin used in a patient with renal transplantation

S. E. Wright, Z. H A Shaikh, J. A. Castillo-Lugo, B. Tanriover

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14 Scopus citations

Abstract

Immune globulin intravenous (human) (IGIV) is effective in the treatment of various autoimmune and inflammatory disorders. Recently, high-dose IGIV 2 g/kg has been utilized in the treatment of antibody-mediated rejection in solid organ transplantation. We report a renal transplant recipient who developed aseptic meningitis and diplopia from abducens nerve (cranial nerve VI) palsy following IGIV administration for antibody-mediated rejection. Potential mechanisms of the IGIV-related aseptic meningitis are elaborated. Clinicians should be aware of aseptic meningitis and cranial nerve palsy as an adverse reaction to IGIV exposure and monitor for its signs and symptoms.

Original language	English (US)
Pages (from-to)	294-297
Number of pages	4
Journal	Transplant Infectious Disease
Volume	10
Issue number	4
DOIs	https://doi.org/10.1111/j.1399-3062.2007.00294.x
State	Published - Aug 2008

Keywords

Abducens nerve palsy
Adverse effect
Aseptic meningitis
Diplopia
IGIV
Immune globulin intravenous
Renal transplant

ASJC Scopus subject areas

Transplantation
Infectious Diseases

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10.1111/j.1399-3062.2007.00294.x

Cite this

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abstract = "Immune globulin intravenous (human) (IGIV) is effective in the treatment of various autoimmune and inflammatory disorders. Recently, high-dose IGIV 2 g/kg has been utilized in the treatment of antibody-mediated rejection in solid organ transplantation. We report a renal transplant recipient who developed aseptic meningitis and diplopia from abducens nerve (cranial nerve VI) palsy following IGIV administration for antibody-mediated rejection. Potential mechanisms of the IGIV-related aseptic meningitis are elaborated. Clinicians should be aware of aseptic meningitis and cranial nerve palsy as an adverse reaction to IGIV exposure and monitor for its signs and symptoms.",

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AU - Tanriover, B.

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Aseptic meningitis and abducens nerve palsy as a serious side effect of high dose intravenous immunoglobulin used in a patient with renal transplantation

Abstract

Keywords

ASJC Scopus subject areas

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