Despite successful experience with large diameter vascular protheses, development of a reliable substitute for small vessels remains elusive. In clinical practice, no artificial prosthesis performs as well as autogenous saphenous vein; however, the limited amount and possible unsuitability of harvested vein may curtail its use, making artificial replacement desirable. This paper discusses the separate and combined effects of matching mechanical properties (compliance) of the prosthesis to the host vessel, of chemically modifying its inner surface to improve blood compatibility, and of improving surgical techniques to minimize the obstruction which results from crimping and hyperplastic cell growth at the anastomotic lines.
|Original language||English (US)|
|Title of host publication||Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings|
|Publisher||Alliance for Engineering in Medicine & Biology|
|Number of pages||1|
|State||Published - 1984|
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