Aspergillus infection in single and double lung transplant recipients

Gloria E. Westney, Steven Kesten, Alberto De Hoyos, Cecilia Chapparro, Timothy Winton, Janet R. Maurer

Research output: Contribution to journalArticle

143 Citations (Scopus)

Abstract

To investigate the clinical manifestations of Aspergillus infections in lung transplant recipients, we reviewed the mycology and autopsy reports of all double (DLT=93) and single (SLT=48) lung transplant recipients from November 1983 to May 1993. Positive Aspergillus cultures were identified in 22% of the recipients (DLT=21, SLT=10). Colonization alone was present in 19 recipients (DLT=16, SLT=3). Complicated Aspergillus infection included Aspergillus bronchitis (DLT=1, SLT=1), aspergilloma (SLT=2), pulmonary invasive aspergillosis (DLT=1, SLT=2), disseminated aspergillosis (DLT=1, SLT=2), empyema (DLT=1), and a retroperitoneal abscess (DLT=1). Symptoms were seen only in patients with complicated lung infections and CXR abnormalities began in the native lung of four SLT recipients. Twenty patients survived (DLT=17, SLT=3) and 11 died (DLT=4, SLT=7) of disseminated aspergillosis (SLT=2), pulmonary invasive disease (DLT=1), bronchiolitis obliterans (DLT=2, SLT=2, CMV pneumonitis (SLT=1), diffuse alveolar damage (SLT=2), and hyperacute rejection (DLT=1). Complicated infection and mortality were more common in SLTs than DLTs (P<0.05). We conclude that infection with Aspergillus is not infrequent in the lung transplantation population. Single lung recipients develop more complicated infection than double lung recipients after Aspergillus infection, with native lung being a potential source of infection.

Original languageEnglish (US)
Pages (from-to)915-919
Number of pages5
JournalTransplantation
Volume61
Issue number6
DOIs
StatePublished - Mar 27 1996

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Aspergillus
Lung
Infection
Aspergillosis
Invasive Pulmonary Aspergillosis
Mycology
Bronchiolitis Obliterans
Empyema
Lung Transplantation
Transplant Recipients
Bronchitis
Abscess
Lung Diseases
Autopsy
Pneumonia
Mortality
Population

ASJC Scopus subject areas

  • Transplantation

Cite this

Westney, G. E., Kesten, S., De Hoyos, A., Chapparro, C., Winton, T., & Maurer, J. R. (1996). Aspergillus infection in single and double lung transplant recipients. Transplantation, 61(6), 915-919. https://doi.org/10.1097/00007890-199603270-00013

Aspergillus infection in single and double lung transplant recipients. / Westney, Gloria E.; Kesten, Steven; De Hoyos, Alberto; Chapparro, Cecilia; Winton, Timothy; Maurer, Janet R.

In: Transplantation, Vol. 61, No. 6, 27.03.1996, p. 915-919.

Research output: Contribution to journalArticle

Westney, GE, Kesten, S, De Hoyos, A, Chapparro, C, Winton, T & Maurer, JR 1996, 'Aspergillus infection in single and double lung transplant recipients', Transplantation, vol. 61, no. 6, pp. 915-919. https://doi.org/10.1097/00007890-199603270-00013
Westney, Gloria E. ; Kesten, Steven ; De Hoyos, Alberto ; Chapparro, Cecilia ; Winton, Timothy ; Maurer, Janet R. / Aspergillus infection in single and double lung transplant recipients. In: Transplantation. 1996 ; Vol. 61, No. 6. pp. 915-919.
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