Aspergillus Niger Infection Associated with Systemic Oxalosis

An Autopsy Diagnosis Without Culture

Walter L. Kemp, Dominick C Cavuoti, Albert Jenkins

Research output: Contribution to journalArticle

Abstract

This case report presents a 60-year-old male with a past medical history that included diabetes mellitus type II, chronic alcoholism, Hepatitis C infection, and presumptive pneumonia who died following a cholecystectomy. At autopsy, in addition to sequelae of the alcohol use (e.g., cirrhosis, splenomegaly, and esophageal varices), two contiguous black discolorations in the right lung composed of friable material and identified as fungal hyphae were found. Associated with the fungal hyphae was oxalic acid deposition. Oxalate crystals were also identified in the kidney of the decedent. Although no fruiting bodies were identified and no cultures were performed, a diagnosis of Aspergillus niger was made based upon the grossly apparent pigment production, lack of pigment within the fungal hyphae, and the oxalic acid production. Systemic oxalosis can occur as a result of an Aspergillus niger infection, and, its presence in the kidney would explain the decedent's worsening renal function prior to death.

Original languageEnglish (US)
Pages (from-to)428-433
Number of pages6
JournalAcademic Forensic Pathology
Volume4
Issue number3
DOIs
StatePublished - Sep 1 2014

Fingerprint

Hyperoxaluria
Hyphae
Oxalic Acid
Autopsy
Kidney
Oxalates
Esophageal and Gastric Varices
Aspergillus niger
Splenomegaly
Cholecystectomy
Chronic Hepatitis C
Type 2 Diabetes Mellitus
Alcoholism
Pneumonia
Fibrosis
Alcohols
Lung
Infection
Aspergillus niger infection

Keywords

  • Aspergilloma
  • Aspergillus niger
  • Autopsy
  • Forensic pathology
  • Oxalate
  • Oxalic acid

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Aspergillus Niger Infection Associated with Systemic Oxalosis : An Autopsy Diagnosis Without Culture. / Kemp, Walter L.; Cavuoti, Dominick C; Jenkins, Albert.

In: Academic Forensic Pathology, Vol. 4, No. 3, 01.09.2014, p. 428-433.

Research output: Contribution to journalArticle

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