Aspirin/antiplatelet agent use improves disease-free survival and reduces the risk of distant metastases in Stage II and III triple-negative breast cancer patients

J. Shiao, K. M. Thomas, A. S. Rahimi, R. Rao, Jingsheng Yan, Xian Jin Xie, M. DaSilva, A. Spangler, M. Leitch, R. Wooldridge, A. Rivers, D. Farr, B. Haley, D. W Nathan Kim

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Purpose: The objective is to define the therapeutic role of antiplatelet agents in a triple-negative breast cancer (TNBC) population. Methods: We performed retrospective analysis using the UTSW TNBC registry containing data from 222 Stage II–III TNBC patients treated between 1998 and 2016. Univariate analysis and multivariable logistic regression models were constructed to identify factors associated with disease-free survival (DFS), distant metastases rate (DMR), and overall survival outcomes. Antiplatelet drug use was determined by review of electronic medical records. Results: A total of 65 patients used antiplatelet (AP) agents, and 157 patients did not use AP agents. Median follow-up for AP and non-AP groups was 41.3 and 40.9 months, respectively. There was an improvement in the AP group compared with the control group in 5-year DFS (80.4% at 5 years compared with 62.3% in the control group, p = 0.04) and 5-year DMR (8.8 vs. 31.9%, p = 0.007). In multivariate analysis, AP use was found to be significantly associated with improvements in DFS and DMR. Conclusions: We illustrate that antiplatelet agent use improves DMR and DFS among a stage II and III TNBC population despite our short follow-up evaluation. Longer follow-up evaluation will be required to determine additional outcome advantage for antiplatelet agent use. Our findings support consideration of investigation of antiplatelet therapy as an adjunctive therapy for TNBC at high risk for disease recurrence.

Original languageEnglish (US)
Pages (from-to)463-471
Number of pages9
JournalBreast Cancer Research and Treatment
Volume161
Issue number3
DOIs
StatePublished - Feb 1 2017

Keywords

  • Anti-platelet
  • Aspirin
  • Estrogen receptor negative
  • Metastases
  • Triple negative

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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