Assessing patterns of agitation in Alzheimer's disease patients with the cohen-mansfield agitation inventory

Elisabeth Koss, Myron Weiner, Christopher Ernesto, Jiska Cohen-Mansfield, Steven H. Ferris, Michael Grundman, Kimberly Schafer, Mary Sano, Leon J. Thai, Ronald Thomas, Peter J. Whitehouse

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

As part of the effort of the NIA Alzheimer's disease cooperative study to develop improved instruments for quantifying effects in Alzheimer's disease (AD) clinical trials, patterns of agitated behaviors were evaluated with the Cohen-Mansfield Agitation Inventory (CMAI) in 241 AD patients and 64 healthy elderly controls with valid baseline assessment on the CMAI. The test-retest reliability of the CMAI over 1 month was good (r = 0.74 to 0.92). Physically and verbally nonaggressive behaviors were most often reported, whereas physically aggressive behaviors were rare. Frequency of agitated behaviors increased with dementia severity, especially for patients with a Mini-Mental Status Exam score of 0-4. Agitation tended to increase in the evening with dementia severity for the more impaired patients. Amount of agitation did increase after 12 months in all but controls and mildly demented patients. The CMAI shows promise for evaluating a unique aspect of behavior and may be useful in assessing the effects of cognitive enhancers and other types of psychotropic drugs on behavior in dementia patients.

Original languageEnglish (US)
JournalAlzheimer Disease and Associated Disorders
Volume11
Issue numberSUPPL. 2
StatePublished - 1997

Fingerprint

Alzheimer Disease
Equipment and Supplies
Dementia
Nootropic Agents
Psychotropic Drugs
Reproducibility of Results
Clinical Trials

Keywords

  • Alzheimer's disease
  • Alzheimer's disease cooperative studyagitation
  • Cohen-mansfield agitation inventorylongitudinal changes
  • Reliability
  • Temporal patterns

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Neuroscience(all)

Cite this

Koss, E., Weiner, M., Ernesto, C., Cohen-Mansfield, J., Ferris, S. H., Grundman, M., ... Whitehouse, P. J. (1997). Assessing patterns of agitation in Alzheimer's disease patients with the cohen-mansfield agitation inventory. Alzheimer Disease and Associated Disorders, 11(SUPPL. 2).

Assessing patterns of agitation in Alzheimer's disease patients with the cohen-mansfield agitation inventory. / Koss, Elisabeth; Weiner, Myron; Ernesto, Christopher; Cohen-Mansfield, Jiska; Ferris, Steven H.; Grundman, Michael; Schafer, Kimberly; Sano, Mary; Thai, Leon J.; Thomas, Ronald; Whitehouse, Peter J.

In: Alzheimer Disease and Associated Disorders, Vol. 11, No. SUPPL. 2, 1997.

Research output: Contribution to journalArticle

Koss, E, Weiner, M, Ernesto, C, Cohen-Mansfield, J, Ferris, SH, Grundman, M, Schafer, K, Sano, M, Thai, LJ, Thomas, R & Whitehouse, PJ 1997, 'Assessing patterns of agitation in Alzheimer's disease patients with the cohen-mansfield agitation inventory', Alzheimer Disease and Associated Disorders, vol. 11, no. SUPPL. 2.
Koss, Elisabeth ; Weiner, Myron ; Ernesto, Christopher ; Cohen-Mansfield, Jiska ; Ferris, Steven H. ; Grundman, Michael ; Schafer, Kimberly ; Sano, Mary ; Thai, Leon J. ; Thomas, Ronald ; Whitehouse, Peter J. / Assessing patterns of agitation in Alzheimer's disease patients with the cohen-mansfield agitation inventory. In: Alzheimer Disease and Associated Disorders. 1997 ; Vol. 11, No. SUPPL. 2.
@article{93309813db3444e0b81ecde9c1ccbde5,
title = "Assessing patterns of agitation in Alzheimer's disease patients with the cohen-mansfield agitation inventory",
abstract = "As part of the effort of the NIA Alzheimer's disease cooperative study to develop improved instruments for quantifying effects in Alzheimer's disease (AD) clinical trials, patterns of agitated behaviors were evaluated with the Cohen-Mansfield Agitation Inventory (CMAI) in 241 AD patients and 64 healthy elderly controls with valid baseline assessment on the CMAI. The test-retest reliability of the CMAI over 1 month was good (r = 0.74 to 0.92). Physically and verbally nonaggressive behaviors were most often reported, whereas physically aggressive behaviors were rare. Frequency of agitated behaviors increased with dementia severity, especially for patients with a Mini-Mental Status Exam score of 0-4. Agitation tended to increase in the evening with dementia severity for the more impaired patients. Amount of agitation did increase after 12 months in all but controls and mildly demented patients. The CMAI shows promise for evaluating a unique aspect of behavior and may be useful in assessing the effects of cognitive enhancers and other types of psychotropic drugs on behavior in dementia patients.",
keywords = "Alzheimer's disease, Alzheimer's disease cooperative studyagitation, Cohen-mansfield agitation inventorylongitudinal changes, Reliability, Temporal patterns",
author = "Elisabeth Koss and Myron Weiner and Christopher Ernesto and Jiska Cohen-Mansfield and Ferris, {Steven H.} and Michael Grundman and Kimberly Schafer and Mary Sano and Thai, {Leon J.} and Ronald Thomas and Whitehouse, {Peter J.}",
year = "1997",
language = "English (US)",
volume = "11",
journal = "Alzheimer Disease and Associated Disorders",
issn = "0893-0341",
publisher = "Lippincott Williams and Wilkins",
number = "SUPPL. 2",

}

TY - JOUR

T1 - Assessing patterns of agitation in Alzheimer's disease patients with the cohen-mansfield agitation inventory

AU - Koss, Elisabeth

AU - Weiner, Myron

AU - Ernesto, Christopher

AU - Cohen-Mansfield, Jiska

AU - Ferris, Steven H.

AU - Grundman, Michael

AU - Schafer, Kimberly

AU - Sano, Mary

AU - Thai, Leon J.

AU - Thomas, Ronald

AU - Whitehouse, Peter J.

PY - 1997

Y1 - 1997

N2 - As part of the effort of the NIA Alzheimer's disease cooperative study to develop improved instruments for quantifying effects in Alzheimer's disease (AD) clinical trials, patterns of agitated behaviors were evaluated with the Cohen-Mansfield Agitation Inventory (CMAI) in 241 AD patients and 64 healthy elderly controls with valid baseline assessment on the CMAI. The test-retest reliability of the CMAI over 1 month was good (r = 0.74 to 0.92). Physically and verbally nonaggressive behaviors were most often reported, whereas physically aggressive behaviors were rare. Frequency of agitated behaviors increased with dementia severity, especially for patients with a Mini-Mental Status Exam score of 0-4. Agitation tended to increase in the evening with dementia severity for the more impaired patients. Amount of agitation did increase after 12 months in all but controls and mildly demented patients. The CMAI shows promise for evaluating a unique aspect of behavior and may be useful in assessing the effects of cognitive enhancers and other types of psychotropic drugs on behavior in dementia patients.

AB - As part of the effort of the NIA Alzheimer's disease cooperative study to develop improved instruments for quantifying effects in Alzheimer's disease (AD) clinical trials, patterns of agitated behaviors were evaluated with the Cohen-Mansfield Agitation Inventory (CMAI) in 241 AD patients and 64 healthy elderly controls with valid baseline assessment on the CMAI. The test-retest reliability of the CMAI over 1 month was good (r = 0.74 to 0.92). Physically and verbally nonaggressive behaviors were most often reported, whereas physically aggressive behaviors were rare. Frequency of agitated behaviors increased with dementia severity, especially for patients with a Mini-Mental Status Exam score of 0-4. Agitation tended to increase in the evening with dementia severity for the more impaired patients. Amount of agitation did increase after 12 months in all but controls and mildly demented patients. The CMAI shows promise for evaluating a unique aspect of behavior and may be useful in assessing the effects of cognitive enhancers and other types of psychotropic drugs on behavior in dementia patients.

KW - Alzheimer's disease

KW - Alzheimer's disease cooperative studyagitation

KW - Cohen-mansfield agitation inventorylongitudinal changes

KW - Reliability

KW - Temporal patterns

UR - http://www.scopus.com/inward/record.url?scp=0030633955&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030633955&partnerID=8YFLogxK

M3 - Article

VL - 11

JO - Alzheimer Disease and Associated Disorders

JF - Alzheimer Disease and Associated Disorders

SN - 0893-0341

IS - SUPPL. 2

ER -