Assessing residual motion for gated proton-beam radiotherapy

Gregory C. Sharp, Hsiao Ming Lu, Alexei Trofimov, Xiaoli Tang, Steve B. Jiang, Julie Turcotte, David P. Gierga, George T Y Chen, Theodore S. Hong

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Gated radiation therapy is a promising method for improving the dose conformality of treatments to moving targets and reducing the total volume of irradiated tissue. Target motion is of particular concern in proton beam radiotherapy, due to the finite range of proton dose deposition in tissue. Gating allows one to reduce the extent of variation, due to respiration, of the radiological depth to target during treatment delivery. However, respiratory surrogates typically used for gating do not always accurately reflect the position of the internal target. For instance, a phase delay often exists between the internal motion and the motion of the surrogate. Another phenomenon, baseline drifting refers to a gradual change in the exhale position over time, which generally affects the external and internal markers differently. This study examines the influence of these two physiological phenomena on gated radiotherapy using an external surrogate.

Original languageEnglish (US)
JournalJournal of Radiation Research
Volume48
Issue numberSUPPL. A
DOIs
StatePublished - 2007

Fingerprint

radiotherapy
proton beams
protons
Protons
radiation therapy
Radiotherapy
Physiological Phenomena
dosage
respiration
Respiration
markers
delivery
Therapeutics
tissues
methodology

Keywords

  • Liver cancer
  • Organ motion
  • Proton radiotherapy

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Radiation

Cite this

Sharp, G. C., Lu, H. M., Trofimov, A., Tang, X., Jiang, S. B., Turcotte, J., ... Hong, T. S. (2007). Assessing residual motion for gated proton-beam radiotherapy. Journal of Radiation Research, 48(SUPPL. A). https://doi.org/10.1269/jrr.48.A55

Assessing residual motion for gated proton-beam radiotherapy. / Sharp, Gregory C.; Lu, Hsiao Ming; Trofimov, Alexei; Tang, Xiaoli; Jiang, Steve B.; Turcotte, Julie; Gierga, David P.; Chen, George T Y; Hong, Theodore S.

In: Journal of Radiation Research, Vol. 48, No. SUPPL. A, 2007.

Research output: Contribution to journalArticle

Sharp, GC, Lu, HM, Trofimov, A, Tang, X, Jiang, SB, Turcotte, J, Gierga, DP, Chen, GTY & Hong, TS 2007, 'Assessing residual motion for gated proton-beam radiotherapy', Journal of Radiation Research, vol. 48, no. SUPPL. A. https://doi.org/10.1269/jrr.48.A55
Sharp, Gregory C. ; Lu, Hsiao Ming ; Trofimov, Alexei ; Tang, Xiaoli ; Jiang, Steve B. ; Turcotte, Julie ; Gierga, David P. ; Chen, George T Y ; Hong, Theodore S. / Assessing residual motion for gated proton-beam radiotherapy. In: Journal of Radiation Research. 2007 ; Vol. 48, No. SUPPL. A.
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