TY - JOUR
T1 - Assessing risks for gastric cancer
T2 - New tools for pathologists
AU - Genta, Robert M.
AU - Rugge, Massimo
PY - 2006/9/21
Y1 - 2006/9/21
N2 - Although the Sydney Systems (original and updated) for the classification of gastritis have contributed substantially to the uniformity of the reporting of gastric conditions, they lack immediacy in conveying to the user information about gastric cancer risk. In this review, we summarize the current understanding of the gastric lesions associated with an increased risk for cancer, and present the rationale for a proposal for new ways of reporting gastritis. In addition to the traditional histopathological data gathered and evaluated according to the Sydney System rules, pathologists could add an assessment expressed as grading and staging of the gastric inflammatory and atrophic lesions and integrate these findings with pertinent laboratory information on pepsinogens and gastrin levels. Such an integrated report could facilitate clinicians' approach to the management of patients with gastric conditions.
AB - Although the Sydney Systems (original and updated) for the classification of gastritis have contributed substantially to the uniformity of the reporting of gastric conditions, they lack immediacy in conveying to the user information about gastric cancer risk. In this review, we summarize the current understanding of the gastric lesions associated with an increased risk for cancer, and present the rationale for a proposal for new ways of reporting gastritis. In addition to the traditional histopathological data gathered and evaluated according to the Sydney System rules, pathologists could add an assessment expressed as grading and staging of the gastric inflammatory and atrophic lesions and integrate these findings with pertinent laboratory information on pepsinogens and gastrin levels. Such an integrated report could facilitate clinicians' approach to the management of patients with gastric conditions.
KW - Gastritis
KW - Gastritis histology
KW - Staging and grading
UR - http://www.scopus.com/inward/record.url?scp=33750120296&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33750120296&partnerID=8YFLogxK
U2 - 10.3748/wjg.v12.i35.5622
DO - 10.3748/wjg.v12.i35.5622
M3 - Review article
C2 - 17007013
AN - SCOPUS:33750120296
SN - 1007-9327
VL - 12
SP - 5622
EP - 5627
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
IS - 35
ER -