Assessing the regression of Barrett esophagus: Don't try it at home

Robert M. Genta

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The discovery of a therapy to induce regression of intestinal metaplasia is one of the main objectives of clinical research in Barrett esophagus. As acid-control drugs have proved ineffective for this purpose, current interest is focused on antireflux surgery, particularly fundoplication. Several studies, including the one discussed in this commentary, have reported regression metaplasia and the absence of progression to high-grade dysplasia or adenocarcinoma after successful fundoplication, suggesting that this procedure is an effective approach for the management of patients with Barrett esophagus. The crucial question whether regression and absence of progression will result in the prevention of Barrett-associated adenocarcinoma may be answered by long-term follow-up of operated patients.

Original languageEnglish (US)
Pages (from-to)127-130
Number of pages4
JournalAdvances in Anatomic Pathology
Volume13
Issue number3
DOIs
StatePublished - May 2006

Fingerprint

Fundoplication
Barrett Esophagus
Metaplasia
Adenocarcinoma
Drug and Narcotic Control
Acids
Research
Therapeutics

Keywords

  • Barrett esophagus-intestinal metaplasia
  • Esophageal adenocarcinoma
  • Fundoplication
  • Regression

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Anatomy

Cite this

Assessing the regression of Barrett esophagus : Don't try it at home. / Genta, Robert M.

In: Advances in Anatomic Pathology, Vol. 13, No. 3, 05.2006, p. 127-130.

Research output: Contribution to journalArticle

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