Assessment of cardiac iron by MRI susceptometry and R2* in patients with thalassemia

Zhiyue J. Wang; Roland Fischer; Zili Chu; Donald H. Mahoney; Brigitta U. Mueller; Raja Muthupillai; Ellen B. James; Rajesh Krishnamurthy; Taylor Chung; Eric Padua; Elliott Vichinsky; Paul Harmatz

doi:10.1016/j.mri.2009.12.001

Assessment of cardiac iron by MRI susceptometry and R2* in patients with thalassemia

Zhiyue J. Wang, Roland Fischer, Zili Chu, Donald H. Mahoney, Brigitta U. Mueller, Raja Muthupillai, Ellen B. James, Rajesh Krishnamurthy, Taylor Chung, Eric Padua, Elliott Vichinsky, Paul Harmatz

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

A magnetic resonance imaging cardiac magnetic susceptometry (MRI-CS) technique for assessing cardiac tissue iron concentration based on phase mapping was developed. Normal control subjects (n=9) and thalassemia patients (n=13) receiving long-term blood transfusion therapy underwent MRI-CS and MRI measurements of the cardiac relaxation rate R2*. Using MRI-CS, subepicardium and subendocardium iron concentrations were quantified exploiting the hemosiderin/ferritin iron specific magnetic susceptibility. The average of subepicardium and subendocardium iron concentrations and R2* of the septum were found to be strongly correlated (r=0.96, P<.0001), and linear regression analysis yielded CIC (μg Fe/g_{wet tissue})=(6.4±0.4)·R2* _septum (s^-1) - (120±40). The results demonstrated that septal R2* indeed measures cardiac iron level.

Original language	English (US)
Pages (from-to)	363-371
Number of pages	9
Journal	Magnetic Resonance Imaging
Volume	28
Issue number	3
DOIs	https://doi.org/10.1016/j.mri.2009.12.001
State	Published - Apr 2010

Keywords

Heart
Iron overload
MRI
Magnetic susceptibility
R2*
Thalassemia

ASJC Scopus subject areas

Biophysics
Biomedical Engineering
Radiology Nuclear Medicine and imaging

Access to Document

10.1016/j.mri.2009.12.001

Cite this

@article{5cc8f138649c4f44bf57b65d6bb3caaa,

title = "Assessment of cardiac iron by MRI susceptometry and R2* in patients with thalassemia",

abstract = "A magnetic resonance imaging cardiac magnetic susceptometry (MRI-CS) technique for assessing cardiac tissue iron concentration based on phase mapping was developed. Normal control subjects (n=9) and thalassemia patients (n=13) receiving long-term blood transfusion therapy underwent MRI-CS and MRI measurements of the cardiac relaxation rate R2*. Using MRI-CS, subepicardium and subendocardium iron concentrations were quantified exploiting the hemosiderin/ferritin iron specific magnetic susceptibility. The average of subepicardium and subendocardium iron concentrations and R2* of the septum were found to be strongly correlated (r=0.96, P<.0001), and linear regression analysis yielded CIC (μg Fe/gwet tissue)=(6.4±0.4)·R2* septum (s-1) - (120±40). The results demonstrated that septal R2* indeed measures cardiac iron level.",

keywords = "Heart, Iron overload, MRI, Magnetic susceptibility, R2*, Thalassemia",

author = "Wang, {Zhiyue J.} and Roland Fischer and Zili Chu and Mahoney, {Donald H.} and Mueller, {Brigitta U.} and Raja Muthupillai and James, {Ellen B.} and Rajesh Krishnamurthy and Taylor Chung and Eric Padua and Elliott Vichinsky and Paul Harmatz",

note = "Funding Information: This work is supported by a Cooley's Anemia Foundation translational research grant and NIH grant M01-RR01271. ",

year = "2010",

month = apr,

doi = "10.1016/j.mri.2009.12.001",

language = "English (US)",

volume = "28",

pages = "363--371",

journal = "Magnetic Resonance Imaging",

issn = "0730-725X",

publisher = "Elsevier Inc.",

number = "3",

}

TY - JOUR

T1 - Assessment of cardiac iron by MRI susceptometry and R2* in patients with thalassemia

AU - Wang, Zhiyue J.

AU - Fischer, Roland

AU - Chu, Zili

AU - Mahoney, Donald H.

AU - Mueller, Brigitta U.

AU - Muthupillai, Raja

AU - James, Ellen B.

AU - Krishnamurthy, Rajesh

AU - Chung, Taylor

AU - Padua, Eric

AU - Vichinsky, Elliott

AU - Harmatz, Paul

N1 - Funding Information: This work is supported by a Cooley's Anemia Foundation translational research grant and NIH grant M01-RR01271.

PY - 2010/4

Y1 - 2010/4

N2 - A magnetic resonance imaging cardiac magnetic susceptometry (MRI-CS) technique for assessing cardiac tissue iron concentration based on phase mapping was developed. Normal control subjects (n=9) and thalassemia patients (n=13) receiving long-term blood transfusion therapy underwent MRI-CS and MRI measurements of the cardiac relaxation rate R2*. Using MRI-CS, subepicardium and subendocardium iron concentrations were quantified exploiting the hemosiderin/ferritin iron specific magnetic susceptibility. The average of subepicardium and subendocardium iron concentrations and R2* of the septum were found to be strongly correlated (r=0.96, P<.0001), and linear regression analysis yielded CIC (μg Fe/gwet tissue)=(6.4±0.4)·R2* septum (s-1) - (120±40). The results demonstrated that septal R2* indeed measures cardiac iron level.

AB - A magnetic resonance imaging cardiac magnetic susceptometry (MRI-CS) technique for assessing cardiac tissue iron concentration based on phase mapping was developed. Normal control subjects (n=9) and thalassemia patients (n=13) receiving long-term blood transfusion therapy underwent MRI-CS and MRI measurements of the cardiac relaxation rate R2*. Using MRI-CS, subepicardium and subendocardium iron concentrations were quantified exploiting the hemosiderin/ferritin iron specific magnetic susceptibility. The average of subepicardium and subendocardium iron concentrations and R2* of the septum were found to be strongly correlated (r=0.96, P<.0001), and linear regression analysis yielded CIC (μg Fe/gwet tissue)=(6.4±0.4)·R2* septum (s-1) - (120±40). The results demonstrated that septal R2* indeed measures cardiac iron level.

KW - Heart

KW - Iron overload

KW - MRI

KW - Magnetic susceptibility

KW - R2

KW - Thalassemia

UR - http://www.scopus.com/inward/record.url?scp=77649342535&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77649342535&partnerID=8YFLogxK

U2 - 10.1016/j.mri.2009.12.001

DO - 10.1016/j.mri.2009.12.001

M3 - Article

C2 - 20061110

AN - SCOPUS:77649342535

SN - 0730-725X

VL - 28

SP - 363

EP - 371

JO - Magnetic Resonance Imaging

JF - Magnetic Resonance Imaging

IS - 3

ER -

Assessment of cardiac iron by MRI susceptometry and R2* in patients with thalassemia

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this