Assessment of cardiac iron by MRI susceptometry and R2* in patients with thalassemia

Zhiyue J. Wang, Roland Fischer, Zili Chu, Donald H. Mahoney, Brigitta U. Mueller, Raja Muthupillai, Ellen B. James, Rajesh Krishnamurthy, Taylor Chung, Eric Padua, Elliott Vichinsky, Paul Harmatz

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


A magnetic resonance imaging cardiac magnetic susceptometry (MRI-CS) technique for assessing cardiac tissue iron concentration based on phase mapping was developed. Normal control subjects (n=9) and thalassemia patients (n=13) receiving long-term blood transfusion therapy underwent MRI-CS and MRI measurements of the cardiac relaxation rate R2*. Using MRI-CS, subepicardium and subendocardium iron concentrations were quantified exploiting the hemosiderin/ferritin iron specific magnetic susceptibility. The average of subepicardium and subendocardium iron concentrations and R2* of the septum were found to be strongly correlated (r=0.96, P<.0001), and linear regression analysis yielded CIC (μg Fe/gwet tissue)=(6.4±0.4)·R2* septum (s-1) - (120±40). The results demonstrated that septal R2* indeed measures cardiac iron level.

Original languageEnglish (US)
Pages (from-to)363-371
Number of pages9
JournalMagnetic Resonance Imaging
Issue number3
StatePublished - Apr 2010


  • Heart
  • Iron overload
  • MRI
  • Magnetic susceptibility
  • R2*
  • Thalassemia

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging


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