Assessment of cardiac iron by MRI susceptometry and R2* in patients with thalassemia

Zhiyue J. Wang, Roland Fischer, Zili Chu, Donald H. Mahoney, Brigitta U. Mueller, Raja Muthupillai, Ellen B. James, Rajesh Krishnamurthy, Taylor Chung, Eric Padua, Elliott Vichinsky, Paul Harmatz

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

A magnetic resonance imaging cardiac magnetic susceptometry (MRI-CS) technique for assessing cardiac tissue iron concentration based on phase mapping was developed. Normal control subjects (n=9) and thalassemia patients (n=13) receiving long-term blood transfusion therapy underwent MRI-CS and MRI measurements of the cardiac relaxation rate R2*. Using MRI-CS, subepicardium and subendocardium iron concentrations were quantified exploiting the hemosiderin/ferritin iron specific magnetic susceptibility. The average of subepicardium and subendocardium iron concentrations and R2* of the septum were found to be strongly correlated (r=0.96, P<.0001), and linear regression analysis yielded CIC (μg Fe/gwet tissue)=(6.4±0.4)·R2* septum (s-1) - (120±40). The results demonstrated that septal R2* indeed measures cardiac iron level.

Original languageEnglish (US)
Pages (from-to)363-371
Number of pages9
JournalMagnetic Resonance Imaging
Volume28
Issue number3
DOIs
StatePublished - Apr 2010

Fingerprint

Thalassemia
Magnetic resonance imaging
Iron
Magnetic resonance
Magnetic Resonance Imaging
Imaging techniques
Tissue
Hemosiderin
Ferritins
Magnetic susceptibility
Linear regression
Regression analysis
Blood Transfusion
Linear Models
Blood
Regression Analysis

Keywords

  • Heart
  • Iron overload
  • Magnetic susceptibility
  • MRI
  • R2*
  • Thalassemia

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Biomedical Engineering

Cite this

Wang, Z. J., Fischer, R., Chu, Z., Mahoney, D. H., Mueller, B. U., Muthupillai, R., ... Harmatz, P. (2010). Assessment of cardiac iron by MRI susceptometry and R2* in patients with thalassemia. Magnetic Resonance Imaging, 28(3), 363-371. https://doi.org/10.1016/j.mri.2009.12.001

Assessment of cardiac iron by MRI susceptometry and R2* in patients with thalassemia. / Wang, Zhiyue J.; Fischer, Roland; Chu, Zili; Mahoney, Donald H.; Mueller, Brigitta U.; Muthupillai, Raja; James, Ellen B.; Krishnamurthy, Rajesh; Chung, Taylor; Padua, Eric; Vichinsky, Elliott; Harmatz, Paul.

In: Magnetic Resonance Imaging, Vol. 28, No. 3, 04.2010, p. 363-371.

Research output: Contribution to journalArticle

Wang, ZJ, Fischer, R, Chu, Z, Mahoney, DH, Mueller, BU, Muthupillai, R, James, EB, Krishnamurthy, R, Chung, T, Padua, E, Vichinsky, E & Harmatz, P 2010, 'Assessment of cardiac iron by MRI susceptometry and R2* in patients with thalassemia', Magnetic Resonance Imaging, vol. 28, no. 3, pp. 363-371. https://doi.org/10.1016/j.mri.2009.12.001
Wang, Zhiyue J. ; Fischer, Roland ; Chu, Zili ; Mahoney, Donald H. ; Mueller, Brigitta U. ; Muthupillai, Raja ; James, Ellen B. ; Krishnamurthy, Rajesh ; Chung, Taylor ; Padua, Eric ; Vichinsky, Elliott ; Harmatz, Paul. / Assessment of cardiac iron by MRI susceptometry and R2* in patients with thalassemia. In: Magnetic Resonance Imaging. 2010 ; Vol. 28, No. 3. pp. 363-371.
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