Assessment of coronary arterial flow and flow reserve in humans with magnetic resonance imaging

W. Gregory Hundley, Richard A. Lange, Geoffrey D. Clarke, Benjamin M. Meshack, Jerry Payne, Charles Landau, Roderick W McColl, Dany E. Sayad, Duwayne L Willett, John E. Willard, L. David Hillis, Ronald M Peshock

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Abstract

Background: The noninvasive measurement of absolute epicardial coronary arterial flow and flow reserve would be useful in the evaluation of patients with coronary circulatory disorders. Phase-contrast magnetic resonance imaging (PC-MRI) has been used to measure coronary arterial flow in animals, but its accuracy in humans is unknown. Methods and Results: Twelve subjects (7 men, 5 women; age, 44 to 67 years) underwent PC-MRI measurements of flow in the left anterior descending coronary artery or one of its diagonal branches at rest and after administration of adenosine (140 μg · kg-1 · min-1 IV). Immediately thereafter, intracoronary Doppler velocity (IDV) and flow measurements were made during cardiac catheterization at rest and after intravenous administration of adenosine. For the 12 patients, the correlation between MRI and invasive measurements of coronary arterial flow slid coronary arterial flow reserve was excellent: coronary flow(MRI) (mL/min) = 0.85 x coronary flow(IDV) (mL/min) + 17 (mL/min), r=.89, and coronary flow reserve(MRI)=0.79 x coronary velocity reserve(IDV)+0.34, r=.89. For the range of coronary arterial flows (18 to 161 mL/min) measured by MRI, the limit of agreement between MRI and catheterization measurements of flow was -13±30 mL/min; for the range of coronary reserves (0.7 to 3.7) measured by MRI, the limit of agreement between the two techniques was 0.1±0.4. Conclusions: Cine velocity-encoded PC-MRI can noninvasively measure absolute coronary arterial flow in the left anterior descending artery in humans. PC-MRI can detect pharmacologically induced changes in coronary arterial flow and can reliably distinguish between those subjects with normal and abnormal coronary artery flow reserve.

Original languageEnglish (US)
Pages (from-to)1502-1508
Number of pages7
JournalCirculation
Volume93
Issue number8
StatePublished - Apr 15 1996

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Magnetic Resonance Imaging
Adenosine
Coronary Vessels
Cardiac Catheterization
Catheterization
Intravenous Administration
Arteries

Keywords

  • coronary disease
  • magnetic resonance imaging
  • regional blood flow

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Hundley, W. G., Lange, R. A., Clarke, G. D., Meshack, B. M., Payne, J., Landau, C., ... Peshock, R. M. (1996). Assessment of coronary arterial flow and flow reserve in humans with magnetic resonance imaging. Circulation, 93(8), 1502-1508.

Assessment of coronary arterial flow and flow reserve in humans with magnetic resonance imaging. / Hundley, W. Gregory; Lange, Richard A.; Clarke, Geoffrey D.; Meshack, Benjamin M.; Payne, Jerry; Landau, Charles; McColl, Roderick W; Sayad, Dany E.; Willett, Duwayne L; Willard, John E.; Hillis, L. David; Peshock, Ronald M.

In: Circulation, Vol. 93, No. 8, 15.04.1996, p. 1502-1508.

Research output: Contribution to journalArticle

Hundley, WG, Lange, RA, Clarke, GD, Meshack, BM, Payne, J, Landau, C, McColl, RW, Sayad, DE, Willett, DL, Willard, JE, Hillis, LD & Peshock, RM 1996, 'Assessment of coronary arterial flow and flow reserve in humans with magnetic resonance imaging', Circulation, vol. 93, no. 8, pp. 1502-1508.
Hundley WG, Lange RA, Clarke GD, Meshack BM, Payne J, Landau C et al. Assessment of coronary arterial flow and flow reserve in humans with magnetic resonance imaging. Circulation. 1996 Apr 15;93(8):1502-1508.
Hundley, W. Gregory ; Lange, Richard A. ; Clarke, Geoffrey D. ; Meshack, Benjamin M. ; Payne, Jerry ; Landau, Charles ; McColl, Roderick W ; Sayad, Dany E. ; Willett, Duwayne L ; Willard, John E. ; Hillis, L. David ; Peshock, Ronald M. / Assessment of coronary arterial flow and flow reserve in humans with magnetic resonance imaging. In: Circulation. 1996 ; Vol. 93, No. 8. pp. 1502-1508.
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abstract = "Background: The noninvasive measurement of absolute epicardial coronary arterial flow and flow reserve would be useful in the evaluation of patients with coronary circulatory disorders. Phase-contrast magnetic resonance imaging (PC-MRI) has been used to measure coronary arterial flow in animals, but its accuracy in humans is unknown. Methods and Results: Twelve subjects (7 men, 5 women; age, 44 to 67 years) underwent PC-MRI measurements of flow in the left anterior descending coronary artery or one of its diagonal branches at rest and after administration of adenosine (140 μg · kg-1 · min-1 IV). Immediately thereafter, intracoronary Doppler velocity (IDV) and flow measurements were made during cardiac catheterization at rest and after intravenous administration of adenosine. For the 12 patients, the correlation between MRI and invasive measurements of coronary arterial flow slid coronary arterial flow reserve was excellent: coronary flow(MRI) (mL/min) = 0.85 x coronary flow(IDV) (mL/min) + 17 (mL/min), r=.89, and coronary flow reserve(MRI)=0.79 x coronary velocity reserve(IDV)+0.34, r=.89. For the range of coronary arterial flows (18 to 161 mL/min) measured by MRI, the limit of agreement between MRI and catheterization measurements of flow was -13±30 mL/min; for the range of coronary reserves (0.7 to 3.7) measured by MRI, the limit of agreement between the two techniques was 0.1±0.4. Conclusions: Cine velocity-encoded PC-MRI can noninvasively measure absolute coronary arterial flow in the left anterior descending artery in humans. PC-MRI can detect pharmacologically induced changes in coronary arterial flow and can reliably distinguish between those subjects with normal and abnormal coronary artery flow reserve.",
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AU - Hundley, W. Gregory

AU - Lange, Richard A.

AU - Clarke, Geoffrey D.

AU - Meshack, Benjamin M.

AU - Payne, Jerry

AU - Landau, Charles

AU - McColl, Roderick W

AU - Sayad, Dany E.

AU - Willett, Duwayne L

AU - Willard, John E.

AU - Hillis, L. David

AU - Peshock, Ronald M

PY - 1996/4/15

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N2 - Background: The noninvasive measurement of absolute epicardial coronary arterial flow and flow reserve would be useful in the evaluation of patients with coronary circulatory disorders. Phase-contrast magnetic resonance imaging (PC-MRI) has been used to measure coronary arterial flow in animals, but its accuracy in humans is unknown. Methods and Results: Twelve subjects (7 men, 5 women; age, 44 to 67 years) underwent PC-MRI measurements of flow in the left anterior descending coronary artery or one of its diagonal branches at rest and after administration of adenosine (140 μg · kg-1 · min-1 IV). Immediately thereafter, intracoronary Doppler velocity (IDV) and flow measurements were made during cardiac catheterization at rest and after intravenous administration of adenosine. For the 12 patients, the correlation between MRI and invasive measurements of coronary arterial flow slid coronary arterial flow reserve was excellent: coronary flow(MRI) (mL/min) = 0.85 x coronary flow(IDV) (mL/min) + 17 (mL/min), r=.89, and coronary flow reserve(MRI)=0.79 x coronary velocity reserve(IDV)+0.34, r=.89. For the range of coronary arterial flows (18 to 161 mL/min) measured by MRI, the limit of agreement between MRI and catheterization measurements of flow was -13±30 mL/min; for the range of coronary reserves (0.7 to 3.7) measured by MRI, the limit of agreement between the two techniques was 0.1±0.4. Conclusions: Cine velocity-encoded PC-MRI can noninvasively measure absolute coronary arterial flow in the left anterior descending artery in humans. PC-MRI can detect pharmacologically induced changes in coronary arterial flow and can reliably distinguish between those subjects with normal and abnormal coronary artery flow reserve.

AB - Background: The noninvasive measurement of absolute epicardial coronary arterial flow and flow reserve would be useful in the evaluation of patients with coronary circulatory disorders. Phase-contrast magnetic resonance imaging (PC-MRI) has been used to measure coronary arterial flow in animals, but its accuracy in humans is unknown. Methods and Results: Twelve subjects (7 men, 5 women; age, 44 to 67 years) underwent PC-MRI measurements of flow in the left anterior descending coronary artery or one of its diagonal branches at rest and after administration of adenosine (140 μg · kg-1 · min-1 IV). Immediately thereafter, intracoronary Doppler velocity (IDV) and flow measurements were made during cardiac catheterization at rest and after intravenous administration of adenosine. For the 12 patients, the correlation between MRI and invasive measurements of coronary arterial flow slid coronary arterial flow reserve was excellent: coronary flow(MRI) (mL/min) = 0.85 x coronary flow(IDV) (mL/min) + 17 (mL/min), r=.89, and coronary flow reserve(MRI)=0.79 x coronary velocity reserve(IDV)+0.34, r=.89. For the range of coronary arterial flows (18 to 161 mL/min) measured by MRI, the limit of agreement between MRI and catheterization measurements of flow was -13±30 mL/min; for the range of coronary reserves (0.7 to 3.7) measured by MRI, the limit of agreement between the two techniques was 0.1±0.4. Conclusions: Cine velocity-encoded PC-MRI can noninvasively measure absolute coronary arterial flow in the left anterior descending artery in humans. PC-MRI can detect pharmacologically induced changes in coronary arterial flow and can reliably distinguish between those subjects with normal and abnormal coronary artery flow reserve.

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KW - magnetic resonance imaging

KW - regional blood flow

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