Assessment of in vivo systemic toxicity and biodistribution of iron-doped silica nanoshells

Natalie Mendez, Alexander Liberman, Jacqueline Corbeil, Christopher Barback, Robert Viveros, James Wang, Jessica Wang-Rodriguez, Sarah L. Blair, Robert Mattrey, David Vera, William Trogler, Andrew C. Kummel

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Silica nanoparticles are an emerging class of biomaterials which may be used as diagnostic and therapeutic tools for biomedical applications. In particular, hollow silica nanoshells are attractive due to their hollow core. Approximately 70% of a 500 nm nanoshell is hollow, therefore more particles can be administered on a mg/kg basis compared to solid nanoparticles. Additionally, their nanoporous shell permits influx/efflux of gases and small molecules. Since the size, shape, and composition of a nanoparticle can dramatically alter its toxicity and biodistribution, the toxicology of these nanomaterials was assessed. A single dose toxicity study was performed in vivo to assess the toxicity of 500 nm iron-doped silica nanoshells at clinically relevant doses of 10-20 mg/kg. This study showed that only a trace amount of silica was detected in the body 10 weeks post-administration. The hematology, biochemistry and pathological results show that the nanoshells exhibit no acute or chronic toxicity in mice.

Original languageEnglish (US)
Pages (from-to)933-942
Number of pages10
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume13
Issue number3
DOIs
StatePublished - Apr 1 2017

Keywords

  • Biodistribution
  • Biomaterials
  • Nanomaterials
  • Silica nanoparticles
  • Toxicity
  • Toxicology

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Molecular Medicine
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

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  • Cite this

    Mendez, N., Liberman, A., Corbeil, J., Barback, C., Viveros, R., Wang, J., Wang-Rodriguez, J., Blair, S. L., Mattrey, R., Vera, D., Trogler, W., & Kummel, A. C. (2017). Assessment of in vivo systemic toxicity and biodistribution of iron-doped silica nanoshells. Nanomedicine: Nanotechnology, Biology, and Medicine, 13(3), 933-942. https://doi.org/10.1016/j.nano.2016.10.018