TY - JOUR
T1 - Assessment of in vivo systemic toxicity and biodistribution of iron-doped silica nanoshells
AU - Mendez, Natalie
AU - Liberman, Alexander
AU - Corbeil, Jacqueline
AU - Barback, Christopher
AU - Viveros, Robert
AU - Wang, James
AU - Wang-Rodriguez, Jessica
AU - Blair, Sarah L.
AU - Mattrey, Robert
AU - Vera, David
AU - Trogler, William
AU - Kummel, Andrew C.
N1 - Funding Information:
This research was supported by National Institutes of Health IMAT 1R33CA177449-01A1 and the National Institutes of Health Cross Training Translation Cancer Researchers in Nanotechnology (CRIN) Support (National Institutes of Health Grant No. 3 R25 CA 153915-03S1). Individual student funding was provided by the NCI Research Supplements to Promote Diversity in Health Related Research Fellowship (National Institutes of Health Grant No. 1R33CA177449-01A1). The authors thank Dr. K. Pestonjamasp and the rest of the Cancer Center Microscopy Core Facility at UCSD (NCI Grant No. P30 CA23100) and the UCSD Histology and Immunohistochemistry core facility.
Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2017/4/1
Y1 - 2017/4/1
N2 - Silica nanoparticles are an emerging class of biomaterials which may be used as diagnostic and therapeutic tools for biomedical applications. In particular, hollow silica nanoshells are attractive due to their hollow core. Approximately 70% of a 500 nm nanoshell is hollow, therefore more particles can be administered on a mg/kg basis compared to solid nanoparticles. Additionally, their nanoporous shell permits influx/efflux of gases and small molecules. Since the size, shape, and composition of a nanoparticle can dramatically alter its toxicity and biodistribution, the toxicology of these nanomaterials was assessed. A single dose toxicity study was performed in vivo to assess the toxicity of 500 nm iron-doped silica nanoshells at clinically relevant doses of 10-20 mg/kg. This study showed that only a trace amount of silica was detected in the body 10 weeks post-administration. The hematology, biochemistry and pathological results show that the nanoshells exhibit no acute or chronic toxicity in mice.
AB - Silica nanoparticles are an emerging class of biomaterials which may be used as diagnostic and therapeutic tools for biomedical applications. In particular, hollow silica nanoshells are attractive due to their hollow core. Approximately 70% of a 500 nm nanoshell is hollow, therefore more particles can be administered on a mg/kg basis compared to solid nanoparticles. Additionally, their nanoporous shell permits influx/efflux of gases and small molecules. Since the size, shape, and composition of a nanoparticle can dramatically alter its toxicity and biodistribution, the toxicology of these nanomaterials was assessed. A single dose toxicity study was performed in vivo to assess the toxicity of 500 nm iron-doped silica nanoshells at clinically relevant doses of 10-20 mg/kg. This study showed that only a trace amount of silica was detected in the body 10 weeks post-administration. The hematology, biochemistry and pathological results show that the nanoshells exhibit no acute or chronic toxicity in mice.
KW - Biodistribution
KW - Biomaterials
KW - Nanomaterials
KW - Silica nanoparticles
KW - Toxicity
KW - Toxicology
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U2 - 10.1016/j.nano.2016.10.018
DO - 10.1016/j.nano.2016.10.018
M3 - Article
C2 - 27840314
AN - SCOPUS:85013655416
SN - 1549-9634
VL - 13
SP - 933
EP - 942
JO - Nanomedicine: Nanotechnology, Biology, and Medicine
JF - Nanomedicine: Nanotechnology, Biology, and Medicine
IS - 3
ER -