TY - JOUR
T1 - Assessment of liver fat quantification in the presence of iron
AU - Bydder, Mark
AU - Shiehmorteza, Masoud
AU - Yokoo, Takeshi
AU - Sugay, Sebastian
AU - Middleton, Michael S.
AU - Girard, Olivier
AU - Schroeder, Michael E.
AU - Wolfson, Tanya
AU - Gamst, Anthony
AU - Sirlin, Claude
N1 - Funding Information:
The authors thank GE Healthcare for research support and Jean Brittain, Michael Carl, Ann Shimikawa, Atsushi Takahasi and Huanzhou Yu for technical help. Research grants were also provided by Berlex (Bayer) and from NIH grant R01 (#DK075128). The study was ancillary (#AS009) to the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN). The NASH CRN is supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (UCSD #1U01DK061734, Data Coordinating Center #5U01DK061730) and the National Institute of Child Health and Human Development (NICHD).
PY - 2010/7
Y1 - 2010/7
N2 - This study assesses the stability of magnetic resonance liver fat measurements against changes in T2* due to the presence of iron, which is a confound for accurate quantification. The liver T2* was experimentally shortened by intravenous infusion of a super paramagnetic iron oxide contrast agent. Low flip angle multiecho gradient echo sequences were performed before, during and after infusion. The liver fat fraction (FF) was calculated in co-localized regions-of-interest using T2* models that assumed no decay, monoexponential decay and biexponential decay. Results show that, when T2* was neglected, there was a strong underestimation of FF and with monoexponential decay there was a weak overestimation of FF. Curve-fitting using the biexponential decay was found to be problematic. The overestimation of FF may be due to remaining deficiencies in the model, although is unlikely to be important for clinical diagnosis of steatosis.
AB - This study assesses the stability of magnetic resonance liver fat measurements against changes in T2* due to the presence of iron, which is a confound for accurate quantification. The liver T2* was experimentally shortened by intravenous infusion of a super paramagnetic iron oxide contrast agent. Low flip angle multiecho gradient echo sequences were performed before, during and after infusion. The liver fat fraction (FF) was calculated in co-localized regions-of-interest using T2* models that assumed no decay, monoexponential decay and biexponential decay. Results show that, when T2* was neglected, there was a strong underestimation of FF and with monoexponential decay there was a weak overestimation of FF. Curve-fitting using the biexponential decay was found to be problematic. The overestimation of FF may be due to remaining deficiencies in the model, although is unlikely to be important for clinical diagnosis of steatosis.
KW - Fat quantification
KW - Iron
KW - Liver
KW - SPIO
UR - http://www.scopus.com/inward/record.url?scp=77953809119&partnerID=8YFLogxK
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U2 - 10.1016/j.mri.2010.03.017
DO - 10.1016/j.mri.2010.03.017
M3 - Article
C2 - 20409663
AN - SCOPUS:77953809119
SN - 0730-725X
VL - 28
SP - 767
EP - 776
JO - Magnetic Resonance Imaging
JF - Magnetic Resonance Imaging
IS - 6
ER -