Assessment of progression and treatment response of optic pathway glioma with positron emission tomography using α-[11C] Methyl-L-Tryptophan

Fangyu Peng, Csaba Juhasz, Kanta Bhambhani, Dafang Wu, Diane C. Chugani, Harry T. Chugani

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Purpose: To report the utility of positron emission tomography (PET) with α-[11C]methyl-L-tryptophan (AMT) for monitoring progression and response to treatment of an isolated optic pathway glioma (OPG) in a 16-year-old girl. Procedures: Positron emission tomography scanning of the brain was performed 20 minutes after intravenous administration of AMT. The AMT-PET images were reconstructed and examined for tumor uptake of the tracer in correlation with coregistered magnetic resonance images. Results: The PET scan demonstrated increased uptake of AMT by OPG in a clinically symptomatic child whose magnetic resonance imaging (MRI) was inconclusive for morphological changes of the tumor. The tracer uptake was dramatically decreased on the images obtained after chemotherapy. Subsequently, AMT-PET revealed a new tumor lesion of increased AMT uptake when the patient developed vision problems and MRI showed no significant interval morphological changes. Significant vision improvement was observed after external beam radiotherapy for the newly identified tumor lesion. Conclusions: Positron emission tomography with α-[11C] methyl-L-tryptophan may be useful for monitoring progression and response to treatment of OPGs, which needs to be further investigated in a prospective study of more patients, including those with neurofibromatosis.

Original languageEnglish (US)
Pages (from-to)106-109
Number of pages4
JournalMolecular Imaging and Biology
Volume9
Issue number3
DOIs
StatePublished - May 1 2007

Keywords

  • Optical pathway glioma
  • Positronemission tomography

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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