Assessment of progression and treatment response of optic pathway glioma with positron emission tomography using α-[11C] Methyl-L-Tryptophan

Fangyu Peng; Csaba Juhasz; Kanta Bhambhani; Dafang Wu; Diane C. Chugani; Harry T. Chugani

doi:10.1007/s11307-007-0090-7

Assessment of progression and treatment response of optic pathway glioma with positron emission tomography using α-[¹¹C] Methyl-L-Tryptophan

Fangyu Peng, Csaba Juhasz, Kanta Bhambhani, Dafang Wu, Diane C. Chugani, Harry T. Chugani

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Purpose: To report the utility of positron emission tomography (PET) with α-[¹¹C]methyl-L-tryptophan (AMT) for monitoring progression and response to treatment of an isolated optic pathway glioma (OPG) in a 16-year-old girl. Procedures: Positron emission tomography scanning of the brain was performed 20 minutes after intravenous administration of AMT. The AMT-PET images were reconstructed and examined for tumor uptake of the tracer in correlation with coregistered magnetic resonance images. Results: The PET scan demonstrated increased uptake of AMT by OPG in a clinically symptomatic child whose magnetic resonance imaging (MRI) was inconclusive for morphological changes of the tumor. The tracer uptake was dramatically decreased on the images obtained after chemotherapy. Subsequently, AMT-PET revealed a new tumor lesion of increased AMT uptake when the patient developed vision problems and MRI showed no significant interval morphological changes. Significant vision improvement was observed after external beam radiotherapy for the newly identified tumor lesion. Conclusions: Positron emission tomography with α-[¹¹C] methyl-L-tryptophan may be useful for monitoring progression and response to treatment of OPGs, which needs to be further investigated in a prospective study of more patients, including those with neurofibromatosis.

Original language	English (US)
Pages (from-to)	106-109
Number of pages	4
Journal	Molecular Imaging and Biology
Volume	9
Issue number	3
DOIs	https://doi.org/10.1007/s11307-007-0090-7
State	Published - May 2007

Keywords

Optical pathway glioma
Positronemission tomography

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

Access to Document

10.1007/s11307-007-0090-7

Cite this

@article{40de466ccf5441f09c06a44662587fdf,

title = "Assessment of progression and treatment response of optic pathway glioma with positron emission tomography using α-[11C] Methyl-L-Tryptophan",

abstract = "Purpose: To report the utility of positron emission tomography (PET) with α-[11C]methyl-L-tryptophan (AMT) for monitoring progression and response to treatment of an isolated optic pathway glioma (OPG) in a 16-year-old girl. Procedures: Positron emission tomography scanning of the brain was performed 20 minutes after intravenous administration of AMT. The AMT-PET images were reconstructed and examined for tumor uptake of the tracer in correlation with coregistered magnetic resonance images. Results: The PET scan demonstrated increased uptake of AMT by OPG in a clinically symptomatic child whose magnetic resonance imaging (MRI) was inconclusive for morphological changes of the tumor. The tracer uptake was dramatically decreased on the images obtained after chemotherapy. Subsequently, AMT-PET revealed a new tumor lesion of increased AMT uptake when the patient developed vision problems and MRI showed no significant interval morphological changes. Significant vision improvement was observed after external beam radiotherapy for the newly identified tumor lesion. Conclusions: Positron emission tomography with α-[11C] methyl-L-tryptophan may be useful for monitoring progression and response to treatment of OPGs, which needs to be further investigated in a prospective study of more patients, including those with neurofibromatosis.",

keywords = "Optical pathway glioma, Positronemission tomography",

author = "Fangyu Peng and Csaba Juhasz and Kanta Bhambhani and Dafang Wu and Chugani, {Diane C.} and Chugani, {Harry T.}",

note = "Funding Information: Acknowledgment. We thank Pulak K. Chakraborty for preparation of the radiopharmaceutical AMT. This project was partly funded by a faculty research development fund awarded to F. P. by The Carman & Ann Adams Department of Pediatrics, School of Medicine, Wayne State University and a grant from the Children{\textquoteright}s Research Center of Michigan granted to C.J.",

year = "2007",

month = may,

doi = "10.1007/s11307-007-0090-7",

language = "English (US)",

volume = "9",

pages = "106--109",

journal = "Molecular Imaging and Biology",

issn = "1536-1632",

publisher = "Springer New York",

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T1 - Assessment of progression and treatment response of optic pathway glioma with positron emission tomography using α-[11C] Methyl-L-Tryptophan

AU - Peng, Fangyu

AU - Juhasz, Csaba

AU - Bhambhani, Kanta

AU - Wu, Dafang

AU - Chugani, Diane C.

AU - Chugani, Harry T.

N1 - Funding Information: Acknowledgment. We thank Pulak K. Chakraborty for preparation of the radiopharmaceutical AMT. This project was partly funded by a faculty research development fund awarded to F. P. by The Carman & Ann Adams Department of Pediatrics, School of Medicine, Wayne State University and a grant from the Children’s Research Center of Michigan granted to C.J.

PY - 2007/5

Y1 - 2007/5

N2 - Purpose: To report the utility of positron emission tomography (PET) with α-[11C]methyl-L-tryptophan (AMT) for monitoring progression and response to treatment of an isolated optic pathway glioma (OPG) in a 16-year-old girl. Procedures: Positron emission tomography scanning of the brain was performed 20 minutes after intravenous administration of AMT. The AMT-PET images were reconstructed and examined for tumor uptake of the tracer in correlation with coregistered magnetic resonance images. Results: The PET scan demonstrated increased uptake of AMT by OPG in a clinically symptomatic child whose magnetic resonance imaging (MRI) was inconclusive for morphological changes of the tumor. The tracer uptake was dramatically decreased on the images obtained after chemotherapy. Subsequently, AMT-PET revealed a new tumor lesion of increased AMT uptake when the patient developed vision problems and MRI showed no significant interval morphological changes. Significant vision improvement was observed after external beam radiotherapy for the newly identified tumor lesion. Conclusions: Positron emission tomography with α-[11C] methyl-L-tryptophan may be useful for monitoring progression and response to treatment of OPGs, which needs to be further investigated in a prospective study of more patients, including those with neurofibromatosis.

AB - Purpose: To report the utility of positron emission tomography (PET) with α-[11C]methyl-L-tryptophan (AMT) for monitoring progression and response to treatment of an isolated optic pathway glioma (OPG) in a 16-year-old girl. Procedures: Positron emission tomography scanning of the brain was performed 20 minutes after intravenous administration of AMT. The AMT-PET images were reconstructed and examined for tumor uptake of the tracer in correlation with coregistered magnetic resonance images. Results: The PET scan demonstrated increased uptake of AMT by OPG in a clinically symptomatic child whose magnetic resonance imaging (MRI) was inconclusive for morphological changes of the tumor. The tracer uptake was dramatically decreased on the images obtained after chemotherapy. Subsequently, AMT-PET revealed a new tumor lesion of increased AMT uptake when the patient developed vision problems and MRI showed no significant interval morphological changes. Significant vision improvement was observed after external beam radiotherapy for the newly identified tumor lesion. Conclusions: Positron emission tomography with α-[11C] methyl-L-tryptophan may be useful for monitoring progression and response to treatment of OPGs, which needs to be further investigated in a prospective study of more patients, including those with neurofibromatosis.

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