Assessment of TANK-binding kinase 1 as a therapeutic target in cancer

Victoria H. Cruz, Rolf A. Brekken

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

TANK-binding kinase 1 (TBK1) is central to multiple biological processes that promote tumorigenesis including cell division, autophagy, innate immune response and AKT-pro survival signaling. TBK1 is well studied and most known for its function in innate immunity. However, the serine threonine protein kinase received significant attention as a synthetic lethal partner and effector of the major oncogene, RAS. This review summarizes newly identified cancer promoting functions of TBK1 and evaluates the therapeutic potential of targeting TBK1 in cancer.

Original languageEnglish (US)
Pages (from-to)83-90
Number of pages8
JournalJournal of Cell Communication and Signaling
Volume12
Issue number1
DOIs
StatePublished - Mar 1 2018

Keywords

  • Autophagy
  • Cancer therapeutic target
  • Pancreatic cancer
  • RAS
  • TBK1

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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