Assessment of TANK-binding kinase 1 as a therapeutic target in cancer

Victoria H. Cruz, Rolf A. Brekken

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

TANK-binding kinase 1 (TBK1) is central to multiple biological processes that promote tumorigenesis including cell division, autophagy, innate immune response and AKT-pro survival signaling. TBK1 is well studied and most known for its function in innate immunity. However, the serine threonine protein kinase received significant attention as a synthetic lethal partner and effector of the major oncogene, RAS. This review summarizes newly identified cancer promoting functions of TBK1 and evaluates the therapeutic potential of targeting TBK1 in cancer.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalJournal of Cell Communication and Signaling
DOIs
StateAccepted/In press - Dec 7 2017

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Phosphotransferases
Innate Immunity
Neoplasms
Biological Phenomena
Protein-Serine-Threonine Kinases
Autophagy
Therapeutics
Oncogenes
Cell Division
Carcinogenesis
Cells

Keywords

  • Autophagy
  • Cancer therapeutic target
  • Pancreatic cancer
  • RAS
  • TBK1

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Assessment of TANK-binding kinase 1 as a therapeutic target in cancer. / Cruz, Victoria H.; Brekken, Rolf A.

In: Journal of Cell Communication and Signaling, 07.12.2017, p. 1-8.

Research output: Contribution to journalArticle

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