TY - JOUR
T1 - Assessment of traumatic brain injury by increased 64Cu uptake on 64CuCl2 PET/CT
AU - Peng, Fangyu
AU - Muzik, Otto
AU - Gatson, Joshua
AU - Kernie, Steven G.
AU - Diaz-Arrastia, Ramon
N1 - Publisher Copyright:
© 2015 by the Society of Nuclear Medicine and Molecular Imaging, Inc.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - Copper is a nutritional trace element required for cell proliferation and wound repair. Methods: To explore increased copper uptake as a biomarker for noninvasive assessment of traumatic brain injury (TBI), experimental TBI in C57BL/6 mice was induced by controlled cortical impact, and 64Cu uptake in the injured cortex was assessed with 64CuCl2 PET/CT. Results: At 24 h after intravenous injection of the tracer, uptake was significantly higher in the injured cortex of TBI mice (1.15 ± 0.53 percentage injected dose per gram of tissue [%ID/g]) than in the uninjured cortex of mice without TBI (0.53 ± 0.07 %ID/g, P 5 0.027) or the cortex of mice that received an intracortical injection of zymosan A (0.62 ± 0.22 %ID/g, P 5 0.025). Furthermore, uptake in the traumatized cortex of untreated TBI mice (1.15 ± 0.53 %ID/g) did not significantly differ from that in minocycline-treated TBI mice (0.93 ± 0.30 %ID/g, P 5 0.33). Conclusion: Overall, the data suggest that increased 64Cu uptake in traumatized brain tissues holds potential as a new biomarker for noninvasive assessment of TBI with 64CuCl2 PET/CT.
AB - Copper is a nutritional trace element required for cell proliferation and wound repair. Methods: To explore increased copper uptake as a biomarker for noninvasive assessment of traumatic brain injury (TBI), experimental TBI in C57BL/6 mice was induced by controlled cortical impact, and 64Cu uptake in the injured cortex was assessed with 64CuCl2 PET/CT. Results: At 24 h after intravenous injection of the tracer, uptake was significantly higher in the injured cortex of TBI mice (1.15 ± 0.53 percentage injected dose per gram of tissue [%ID/g]) than in the uninjured cortex of mice without TBI (0.53 ± 0.07 %ID/g, P 5 0.027) or the cortex of mice that received an intracortical injection of zymosan A (0.62 ± 0.22 %ID/g, P 5 0.025). Furthermore, uptake in the traumatized cortex of untreated TBI mice (1.15 ± 0.53 %ID/g) did not significantly differ from that in minocycline-treated TBI mice (0.93 ± 0.30 %ID/g, P 5 0.33). Conclusion: Overall, the data suggest that increased 64Cu uptake in traumatized brain tissues holds potential as a new biomarker for noninvasive assessment of TBI with 64CuCl2 PET/CT.
KW - Copper metabolism
KW - Cu-chloride
KW - Neuroimaging
KW - Positron emission tomography
KW - Traumatic brain injury
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U2 - 10.2967/jnumed.115.154575
DO - 10.2967/jnumed.115.154575
M3 - Article
C2 - 26112025
AN - SCOPUS:84938862644
SN - 0161-5505
VL - 56
SP - 1252
EP - 1257
JO - Journal of Nuclear Medicine
JF - Journal of Nuclear Medicine
IS - 8
ER -