Assessment of traumatic brain injury by increased <sup>64</sup>Cu uptake on <sup>64</sup>CuCl<inf>2</inf> PET/CT

Fangyu Peng, Otto Muzik, Joshua Gatson, Steven G. Kernie, Ramon Diaz-Arrastia

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Copper is a nutritional trace element required for cell proliferation and wound repair. Methods: To explore increased copper uptake as a biomarker for noninvasive assessment of traumatic brain injury (TBI), experimental TBI in C57BL/6 mice was induced by controlled cortical impact, and <sup>64</sup>Cu uptake in the injured cortex was assessed with <sup>64</sup>CuCl2 PET/CT. Results: At 24 h after intravenous injection of the tracer, uptake was significantly higher in the injured cortex of TBI mice (1.15 ± 0.53 percentage injected dose per gram of tissue [%ID/g]) than in the uninjured cortex of mice without TBI (0.53 ± 0.07 %ID/g, P 5 0.027) or the cortex of mice that received an intracortical injection of zymosan A (0.62 ± 0.22 %ID/g, P 5 0.025). Furthermore, uptake in the traumatized cortex of untreated TBI mice (1.15 ± 0.53 %ID/g) did not significantly differ from that in minocycline-treated TBI mice (0.93 ± 0.30 %ID/g, P 5 0.33). Conclusion: Overall, the data suggest that increased <sup>64</sup>Cu uptake in traumatized brain tissues holds potential as a new biomarker for noninvasive assessment of TBI with <sup>64</sup>CuCl2 PET/CT.

Original languageEnglish (US)
Pages (from-to)1252-1257
Number of pages6
JournalJournal of Nuclear Medicine
Volume56
Issue number8
DOIs
StatePublished - Aug 1 2015

Fingerprint

Copper
Biomarkers
Minocycline
Zymosan
Trace Elements
Traumatic Brain Injury
Inbred C57BL Mouse
Intravenous Injections
Cell Proliferation
Injections
Wounds and Injuries
Brain

Keywords

  • <sup>64</sup>Cu-chloride
  • Copper metabolism
  • Neuroimaging
  • Positron emission tomography
  • Traumatic brain injury

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Assessment of traumatic brain injury by increased <sup>64</sup>Cu uptake on <sup>64</sup>CuCl<inf>2</inf> PET/CT. / Peng, Fangyu; Muzik, Otto; Gatson, Joshua; Kernie, Steven G.; Diaz-Arrastia, Ramon.

In: Journal of Nuclear Medicine, Vol. 56, No. 8, 01.08.2015, p. 1252-1257.

Research output: Contribution to journalArticle

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abstract = "Copper is a nutritional trace element required for cell proliferation and wound repair. Methods: To explore increased copper uptake as a biomarker for noninvasive assessment of traumatic brain injury (TBI), experimental TBI in C57BL/6 mice was induced by controlled cortical impact, and 64Cu uptake in the injured cortex was assessed with 64CuCl2 PET/CT. Results: At 24 h after intravenous injection of the tracer, uptake was significantly higher in the injured cortex of TBI mice (1.15 ± 0.53 percentage injected dose per gram of tissue [{\%}ID/g]) than in the uninjured cortex of mice without TBI (0.53 ± 0.07 {\%}ID/g, P 5 0.027) or the cortex of mice that received an intracortical injection of zymosan A (0.62 ± 0.22 {\%}ID/g, P 5 0.025). Furthermore, uptake in the traumatized cortex of untreated TBI mice (1.15 ± 0.53 {\%}ID/g) did not significantly differ from that in minocycline-treated TBI mice (0.93 ± 0.30 {\%}ID/g, P 5 0.33). Conclusion: Overall, the data suggest that increased 64Cu uptake in traumatized brain tissues holds potential as a new biomarker for noninvasive assessment of TBI with 64CuCl2 PET/CT.",
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