Association between a novel human coronavirus and kawasaki disease

Frank Esper, Eugene D. Shapiro, Carla Weibel, David Ferguson, Marie L. Landry, Jeffrey Kahn

Research output: Contribution to journalArticle

141 Citations (Scopus)

Abstract

Kawasaki disease is a systemic vasculitis of childhood; its etiology is unknown. We identified evidence of a novel human coronavirus, designated "New Haven coronavirus" (HCoV-NH), in respiratory secretions from a 6-month-old infant with classic Kawasaki disease. To further investigate the possible association between HCoV-NH infection and Kawasaki disease, we conducted a case-control study. Specimens of respiratory secretions from 8 (72.7%) of 11 children with Kawasaki disease and from 1 (4.5%) of 22 control subjects (children without Kawasaki disease matched by age and the time the specimens were obtained) tested positive for HCoV-NH by reverse-transcriptase polymerase chain reaction (Mantel-Haenszel matched odds ratio, 16.0 [95% confidence interval, 3.4-74.4]; P = .0015). These data suggest that HCoV-NH infection is associated with Kawasaki disease.

Original languageEnglish (US)
Pages (from-to)499-502
Number of pages4
JournalJournal of Infectious Diseases
Volume191
Issue number4
DOIs
StatePublished - Feb 15 2005

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Mucocutaneous Lymph Node Syndrome
Coronavirus
Coronavirus Infections
Systemic Vasculitis
Reverse Transcriptase Polymerase Chain Reaction
Case-Control Studies
Odds Ratio
Confidence Intervals

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Esper, F., Shapiro, E. D., Weibel, C., Ferguson, D., Landry, M. L., & Kahn, J. (2005). Association between a novel human coronavirus and kawasaki disease. Journal of Infectious Diseases, 191(4), 499-502. https://doi.org/10.1086/428291

Association between a novel human coronavirus and kawasaki disease. / Esper, Frank; Shapiro, Eugene D.; Weibel, Carla; Ferguson, David; Landry, Marie L.; Kahn, Jeffrey.

In: Journal of Infectious Diseases, Vol. 191, No. 4, 15.02.2005, p. 499-502.

Research output: Contribution to journalArticle

Esper, F, Shapiro, ED, Weibel, C, Ferguson, D, Landry, ML & Kahn, J 2005, 'Association between a novel human coronavirus and kawasaki disease', Journal of Infectious Diseases, vol. 191, no. 4, pp. 499-502. https://doi.org/10.1086/428291
Esper, Frank ; Shapiro, Eugene D. ; Weibel, Carla ; Ferguson, David ; Landry, Marie L. ; Kahn, Jeffrey. / Association between a novel human coronavirus and kawasaki disease. In: Journal of Infectious Diseases. 2005 ; Vol. 191, No. 4. pp. 499-502.
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