Association between circulating soluble receptor for advanced glycation end products and atherosclerosis: Observations from the Dallas Heart Study

Jason B. Lindsey, James A de Lemos, Francesco Cipollone, Colby R. Ayers, Anand K Rohatgi, David A. Morrow, Amit Khera, Darren K McGuire

Research output: Contribution to journalArticle

75 Scopus citations

Abstract

OBJECTIVE - To determine the association between circulating soluble receptor for advanced glycation end products (sRAGE) and coronary atherosclerosis. RESEARCH DESIGN AND METHODS - Using data from the Dallas Heart Study, a probability-based population sample, the association between plasma levels of sRAGE and coronary artery calcium (CAC) was assessed among 2,571 subjects with complete imaging and sRAGE data. RESULTS - An inverse graded association was observed between sRAGE quartiles and CAC, with CAC prevalence of 28.5% in quartile 1 compared with 15.7% in quartile 4 (P < 0.0001). After multivariable adjustment, the associations between sRAGE levels in the first and second quartiles (versus fourth quartile) and CAC remained statistically significant (adjusted odds ratio 1.71 [95% CI 1.2-2.4] and 1.5 [1.0 -2.1], respectively). CONCLUSIONS - sRAGE is a novel biomarker that is inversely associated with coronary atherosclerosis. The role of sRAGE in the pathobiology of atherosclerosis and its potential prognostic and therapeutic implications warrant further investigation.

Original languageEnglish (US)
Pages (from-to)1218-1220
Number of pages3
JournalDiabetes care
Volume32
Issue number7
DOIs
StatePublished - Jul 1 2009

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

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