TY - JOUR
T1 - Association between cognitive impairment and chronic kidney disease in Mexican Americans
AU - Szerlip, Harold M.
AU - Edwards, Melissa L.
AU - Williams, Benjamin J.
AU - Johnson, Leigh A.
AU - Vintimilla, Raul M.
AU - O'Bryant, Sid E.
N1 - Publisher Copyright:
© 2015 The Authors. The Journal of the American Geriatrics Society published by Wiley Periodicals, Inc. on behalf of The American Geriatrics Society.
PY - 2015/10
Y1 - 2015/10
N2 - Objectives To analyze the association between chronic kidney disease (CKD) and mild cognitive impairment (MCI) in Mexican Americans and to determine whether there is a blood-based proteomic profile linking CKD to MCI. Design Retrospective analysis of cohort study. Setting Health and Aging Brain among Latino Elders study. Participants Mexican Americans (N = 437, 105 men, 332 women). Measurements Data were analyzed to examine the link between estimated glomerular filtration rate (eGFR) and detailed neuropsychological functioning. Serum proteomic markers were also examined. Results Lower eGFR levels were associated with significantly poorer neuropsychological functioning across multiple domains. After adjusting for age, sex, education, and diabetes mellitus, participants with an eGFR less than 45 mL/min per 1.73 m2 performed significantly worse than those with an eGFR from 45 to 59 mL/min per 1.73 m2 or 60 mL/min per 1.73 m2 and higher in processing speed (F = 14.1, P <.001), executive functioning (F = 4.5, P =.01), visuospatial skills (F = 4.8, P =.009), and global cognitive functioning (F = 6.2, P =.002). Participants with an eGFR less than 45 mL/min per 1.73 m2 also performed significantly worse than those with an eGFR of 60 mL/min per 1.73 m2 or greater on delayed memory (F = 3.8, P =.02). There was a trend toward lower eGFR levels being associated with greater risk of MCI (odds ratio (OR) = 2.4, 95% confidence interval (CI) = 0.91-6.1, P =.07), which was stronger for men (OR = 9.6, 95% CI = 1.3-74.3, P =.03). A serum proteomic profile consisting of Factor VII, interleukin-10, C-reactive protein, and fatty acid binding protein was 93% accurate in detecting CKD-related MCI. Conclusion Lower eGFR was associated with significantly poorer neuropsychological functioning in Mexican Americans. A blood-based profile was generated that was highly accurate in detecting CKD-related MCI. A blood profile capable of predicting CKD-related cognitive impairment would be of benefit for the design of clinical interventions.
AB - Objectives To analyze the association between chronic kidney disease (CKD) and mild cognitive impairment (MCI) in Mexican Americans and to determine whether there is a blood-based proteomic profile linking CKD to MCI. Design Retrospective analysis of cohort study. Setting Health and Aging Brain among Latino Elders study. Participants Mexican Americans (N = 437, 105 men, 332 women). Measurements Data were analyzed to examine the link between estimated glomerular filtration rate (eGFR) and detailed neuropsychological functioning. Serum proteomic markers were also examined. Results Lower eGFR levels were associated with significantly poorer neuropsychological functioning across multiple domains. After adjusting for age, sex, education, and diabetes mellitus, participants with an eGFR less than 45 mL/min per 1.73 m2 performed significantly worse than those with an eGFR from 45 to 59 mL/min per 1.73 m2 or 60 mL/min per 1.73 m2 and higher in processing speed (F = 14.1, P <.001), executive functioning (F = 4.5, P =.01), visuospatial skills (F = 4.8, P =.009), and global cognitive functioning (F = 6.2, P =.002). Participants with an eGFR less than 45 mL/min per 1.73 m2 also performed significantly worse than those with an eGFR of 60 mL/min per 1.73 m2 or greater on delayed memory (F = 3.8, P =.02). There was a trend toward lower eGFR levels being associated with greater risk of MCI (odds ratio (OR) = 2.4, 95% confidence interval (CI) = 0.91-6.1, P =.07), which was stronger for men (OR = 9.6, 95% CI = 1.3-74.3, P =.03). A serum proteomic profile consisting of Factor VII, interleukin-10, C-reactive protein, and fatty acid binding protein was 93% accurate in detecting CKD-related MCI. Conclusion Lower eGFR was associated with significantly poorer neuropsychological functioning in Mexican Americans. A blood-based profile was generated that was highly accurate in detecting CKD-related MCI. A blood profile capable of predicting CKD-related cognitive impairment would be of benefit for the design of clinical interventions.
KW - Mexican Americans
KW - chronic kidney disease
KW - cognitive impairment
KW - neuropsychological testing
KW - proteomics
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U2 - 10.1111/jgs.13665
DO - 10.1111/jgs.13665
M3 - Article
C2 - 26456700
AN - SCOPUS:84944607237
SN - 0002-8614
VL - 63
SP - 2023
EP - 2028
JO - Journal of the American Geriatrics Society
JF - Journal of the American Geriatrics Society
IS - 10
ER -