Association between cognitive impairment and chronic kidney disease in Mexican Americans

Harold M. Szerlip, Melissa L. Edwards, Benjamin J. Williams, Leigh A. Johnson, Raul M. Vintimilla, Sid E. O'Bryant

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objectives To analyze the association between chronic kidney disease (CKD) and mild cognitive impairment (MCI) in Mexican Americans and to determine whether there is a blood-based proteomic profile linking CKD to MCI. Design Retrospective analysis of cohort study. Setting Health and Aging Brain among Latino Elders study. Participants Mexican Americans (N = 437, 105 men, 332 women). Measurements Data were analyzed to examine the link between estimated glomerular filtration rate (eGFR) and detailed neuropsychological functioning. Serum proteomic markers were also examined. Results Lower eGFR levels were associated with significantly poorer neuropsychological functioning across multiple domains. After adjusting for age, sex, education, and diabetes mellitus, participants with an eGFR less than 45 mL/min per 1.73 m2 performed significantly worse than those with an eGFR from 45 to 59 mL/min per 1.73 m2 or 60 mL/min per 1.73 m2 and higher in processing speed (F = 14.1, P 2 also performed significantly worse than those with an eGFR of 60 mL/min per 1.73 m2 or greater on delayed memory (F = 3.8, P =.02). There was a trend toward lower eGFR levels being associated with greater risk of MCI (odds ratio (OR) = 2.4, 95% confidence interval (CI) = 0.91-6.1, P =.07), which was stronger for men (OR = 9.6, 95% CI = 1.3-74.3, P =.03). A serum proteomic profile consisting of Factor VII, interleukin-10, C-reactive protein, and fatty acid binding protein was 93% accurate in detecting CKD-related MCI. Conclusion Lower eGFR was associated with significantly poorer neuropsychological functioning in Mexican Americans. A blood-based profile was generated that was highly accurate in detecting CKD-related MCI. A blood profile capable of predicting CKD-related cognitive impairment would be of benefit for the design of clinical interventions.

Original languageEnglish (US)
Pages (from-to)2023-2028
Number of pages6
JournalJournal of the American Geriatrics Society
Volume63
Issue number10
DOIs
StatePublished - Oct 1 2015

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Glomerular Filtration Rate
Chronic Renal Insufficiency
Proteomics
Odds Ratio
Repression (Psychology)
Confidence Intervals
Fatty Acid-Binding Proteins
Factor VII
Sex Education
Cognitive Dysfunction
Hispanic Americans
Interleukin-10
C-Reactive Protein
Diabetes Mellitus
Cohort Studies
Biomarkers
Health
Brain
Serum

Keywords

  • chronic kidney disease
  • cognitive impairment
  • Mexican Americans
  • neuropsychological testing
  • proteomics

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Szerlip, H. M., Edwards, M. L., Williams, B. J., Johnson, L. A., Vintimilla, R. M., & O'Bryant, S. E. (2015). Association between cognitive impairment and chronic kidney disease in Mexican Americans. Journal of the American Geriatrics Society, 63(10), 2023-2028. https://doi.org/10.1111/jgs.13665

Association between cognitive impairment and chronic kidney disease in Mexican Americans. / Szerlip, Harold M.; Edwards, Melissa L.; Williams, Benjamin J.; Johnson, Leigh A.; Vintimilla, Raul M.; O'Bryant, Sid E.

In: Journal of the American Geriatrics Society, Vol. 63, No. 10, 01.10.2015, p. 2023-2028.

Research output: Contribution to journalArticle

Szerlip, HM, Edwards, ML, Williams, BJ, Johnson, LA, Vintimilla, RM & O'Bryant, SE 2015, 'Association between cognitive impairment and chronic kidney disease in Mexican Americans', Journal of the American Geriatrics Society, vol. 63, no. 10, pp. 2023-2028. https://doi.org/10.1111/jgs.13665
Szerlip HM, Edwards ML, Williams BJ, Johnson LA, Vintimilla RM, O'Bryant SE. Association between cognitive impairment and chronic kidney disease in Mexican Americans. Journal of the American Geriatrics Society. 2015 Oct 1;63(10):2023-2028. https://doi.org/10.1111/jgs.13665
Szerlip, Harold M. ; Edwards, Melissa L. ; Williams, Benjamin J. ; Johnson, Leigh A. ; Vintimilla, Raul M. ; O'Bryant, Sid E. / Association between cognitive impairment and chronic kidney disease in Mexican Americans. In: Journal of the American Geriatrics Society. 2015 ; Vol. 63, No. 10. pp. 2023-2028.
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abstract = "Objectives To analyze the association between chronic kidney disease (CKD) and mild cognitive impairment (MCI) in Mexican Americans and to determine whether there is a blood-based proteomic profile linking CKD to MCI. Design Retrospective analysis of cohort study. Setting Health and Aging Brain among Latino Elders study. Participants Mexican Americans (N = 437, 105 men, 332 women). Measurements Data were analyzed to examine the link between estimated glomerular filtration rate (eGFR) and detailed neuropsychological functioning. Serum proteomic markers were also examined. Results Lower eGFR levels were associated with significantly poorer neuropsychological functioning across multiple domains. After adjusting for age, sex, education, and diabetes mellitus, participants with an eGFR less than 45 mL/min per 1.73 m2 performed significantly worse than those with an eGFR from 45 to 59 mL/min per 1.73 m2 or 60 mL/min per 1.73 m2 and higher in processing speed (F = 14.1, P 2 also performed significantly worse than those with an eGFR of 60 mL/min per 1.73 m2 or greater on delayed memory (F = 3.8, P =.02). There was a trend toward lower eGFR levels being associated with greater risk of MCI (odds ratio (OR) = 2.4, 95{\%} confidence interval (CI) = 0.91-6.1, P =.07), which was stronger for men (OR = 9.6, 95{\%} CI = 1.3-74.3, P =.03). A serum proteomic profile consisting of Factor VII, interleukin-10, C-reactive protein, and fatty acid binding protein was 93{\%} accurate in detecting CKD-related MCI. Conclusion Lower eGFR was associated with significantly poorer neuropsychological functioning in Mexican Americans. A blood-based profile was generated that was highly accurate in detecting CKD-related MCI. A blood profile capable of predicting CKD-related cognitive impairment would be of benefit for the design of clinical interventions.",
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