TY - JOUR
T1 - Association between history of bariatric surgery and graft rejection among solid organ transplant recipients
AU - Harrington, Claire R.
AU - Soghikian, Max
AU - Gregory, Dyanna
AU - Wilcox, Jane E.
AU - Shetty, Aneesha
AU - Rinella, Mary E.
AU - Ladner, Daniela P.
AU - VanWagner, Lisa B.
N1 - Funding Information:
Dr. VanWagner is supported by the National Heart, Lung and Blood Institute grant number, K23 HL136891 . The Northwestern Medicine Enterprise Data Warehouse (NMEDW) is funded, in part, by the National Center for Advancing Translational Sciences (NCATS) of the NIH research grant UL1TR001422 to the Northwestern University Clinical and Translational Sciences (NUCATS) Institute.
Publisher Copyright:
© 2020
PY - 2021/3
Y1 - 2021/3
N2 - Objective: We sought to assess the potential association between history of bariatric surgery and graft rejection among solid organ transplant (SOT) recipients. Methods: We conducted a single-center retrospective study of adult (age ≥18 years) SOT recipients (2000-2015) at a large tertiary care transplant network with graft rejection and bariatric surgery history according to the international classification of diseases 9th revision. Data were analyzed using ANOVA, Chi Square, Fisher Exact tests, and logistic regression. Results: Of 4363 SOT recipients, 72.6% had a history of graft rejection and 55 (1.3%) had a history of bariatric surgery. On univariate analysis, patients with graft rejection were more likely to have a history of bariatric surgery than those without organ rejection (1.5% vs. 0.7%, p=0.015). In multivariable analysis adjusted for age, transplant organ type, and history of calcineurin-based immunosuppression, there was increased odds of rejection among those with a history of bariatric surgery (Odds Ratio (OR): 3.01, 95% Confidence Interval (CI):0.98-4.46, p=0.05). However, when adjusted for body mass index at transplant, the association was attenuated (OR:3.48, CI:0.81-14.9, p=0.10). Conclusion: Our single-center data indicate that the relationship between a history of bariatric surgery and graft rejection after SOT may be explained by obesity.
AB - Objective: We sought to assess the potential association between history of bariatric surgery and graft rejection among solid organ transplant (SOT) recipients. Methods: We conducted a single-center retrospective study of adult (age ≥18 years) SOT recipients (2000-2015) at a large tertiary care transplant network with graft rejection and bariatric surgery history according to the international classification of diseases 9th revision. Data were analyzed using ANOVA, Chi Square, Fisher Exact tests, and logistic regression. Results: Of 4363 SOT recipients, 72.6% had a history of graft rejection and 55 (1.3%) had a history of bariatric surgery. On univariate analysis, patients with graft rejection were more likely to have a history of bariatric surgery than those without organ rejection (1.5% vs. 0.7%, p=0.015). In multivariable analysis adjusted for age, transplant organ type, and history of calcineurin-based immunosuppression, there was increased odds of rejection among those with a history of bariatric surgery (Odds Ratio (OR): 3.01, 95% Confidence Interval (CI):0.98-4.46, p=0.05). However, when adjusted for body mass index at transplant, the association was attenuated (OR:3.48, CI:0.81-14.9, p=0.10). Conclusion: Our single-center data indicate that the relationship between a history of bariatric surgery and graft rejection after SOT may be explained by obesity.
KW - Comorbidities
KW - Graft survival
KW - Immunosuppressant
KW - Liver transplantation
KW - Obesity
KW - Rejection
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U2 - 10.1016/j.tpr.2020.100071
DO - 10.1016/j.tpr.2020.100071
M3 - Article
AN - SCOPUS:85099515669
SN - 2451-9596
VL - 6
JO - Transplantation Reports
JF - Transplantation Reports
IS - 1
M1 - 100071
ER -