Association Between Mobility Mode and C-Reactive Protein Levels in Men With Chronic Spinal Cord Injury

Leslie R. Morse, Kelly Stolzmann, Hiep P. Nguyen, Nitin B. Jain, Cara Zayac, David R. Gagnon, Carlos G. Tun, Eric Garshick

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Morse LR, Stolzmann K, Nguyen HP, Jain NB, Zayac C, Gagnon D, Tun CG, Garshick E. Association between mobility mode and C-reactive protein levels in men with chronic spinal cord injury. Objective: To assess clinical determinants of systemic inflammation in persons with chronic spinal cord injury (SCI). Design: Cross-sectional survey. Setting: Veterans Affairs medical center. Participants: As part of an epidemiologic study assessing SCI-related health conditions, 63 men with chronic SCI provided a blood sample and information regarding locomotive mode and personal habits. Interventions: Not applicable. Main Outcome Measure: Plasma high-sensitivity C-reactive protein (CRP). Results: The mean ± standard deviation age was 56±14y, and participants were assessed 21±13y after injury. Adjusting for heart disease, hypertension, and body mass index (BMI), the mean CRP in 12 motorized wheelchair users (5.11mg/L) was not significantly greater than 23 participants who used a manual wheelchair (2.19mg/L) (P=.085) but was significantly greater than the 17 who walked with an assistive device (1.41mg/L) (P=.005) and the 12 who walked independently (1.63mg/L) (P=.027). CRP was significantly greater in participants with obesity but was not related to age, smoking, or SCI level and severity. CRP was elevated in participants reporting a urinary tract infection (UTI) or pressure ulcer within a year, but adjustment for this did not account for the elevated CRP in motorized wheelchair users. Conclusions: These results suggest that CRP in chronic SCI is independently related to locomotive mode, BMI, and a history of pressure ulcers and UTI. It is suggested that future studies in SCI investigate whether modifying these factors influence systemic inflammation and cardiovascular health.

Original languageEnglish (US)
Pages (from-to)726-731
Number of pages6
JournalArchives of physical medicine and rehabilitation
Volume89
Issue number4
DOIs
StatePublished - Apr 1 2008
Externally publishedYes

Keywords

  • Cardiovascular diseases
  • Inflammation
  • Rehabilitation
  • Spinal cord injuries

ASJC Scopus subject areas

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Rehabilitation

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