Association between plasma homocysteine and peripheral arterial disease in older persons

Wilbert S. Aronow, Chul Ahn

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Background. Plasma homocysteine is a risk factor for peripheral arterial disease. Methods. In a cross-sectional study design we investigated the association between plasma homocysteine, vitamin B12 and folate concentrations, and the prevalence of peripheral arterial disease in 158 men and 362 women, mean age 81 ± 8 years. Results. Univariate analysis showed that plasma homocysteine, vitamin B12 (inverse association) and folate (inverse association) concentrations and increased plasma homocysteine and low or indeterminate vitamin B12 concentrations were risk factors for peripheral arterial disease in older men and women. Stepwise multiple logistic regression analysis showed that significant independent risk factors for peripheral arterial disease were a greater value of plasma homocysteine (P = 0.0001; odds ratio = 1.125) and a low value of plasma folate (P = 0.0001; odds ratio = 0.709). Conclusions. High plasma concentrations of homocysteine and low plasma concentrations of folate are significant independent risk factors for peripheral arterial disease in older men and women.

Original languageEnglish (US)
Pages (from-to)49-50
Number of pages2
JournalCoronary artery disease
Volume9
Issue number1
DOIs
StatePublished - Jan 1 1998

Keywords

  • Arterial occlusive disease
  • Folic acid
  • Homocysteine
  • Vitamin B

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Association between plasma homocysteine and peripheral arterial disease in older persons'. Together they form a unique fingerprint.

Cite this