Association between Serum Soluble Klotho Levels and Mortality in Chronic Hemodialysis Patients

Naoko Otani-Takei, Takahiro Masuda, Tetsu Akimoto, Sumiko Honma, Yuko Watanabe, Kazuhiro Shiizaki, Takuya Miki, Eiji Kusano, Yasushi Asano, Makoto Kuro-O, Daisuke Nagata

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Klotho is a single-pass transmembrane protein predominantly expressed in the kidney. The extracellular domain of Klotho is subject to ectodomain shedding and is released into the circulation as a soluble form. Soluble Klotho is also generated from alternative splicing of the Klotho gene. In mice, defects in Klotho expression lead to complex phenotypes resembling those observed in dialysis patients. However, the relationship between the level of serum soluble Klotho and overall survival in hemodialysis patients, who exhibit a state of Klotho deficiency, remains to be delineated. Here we prospectively followed a cohort of 63 patients with a mean duration of chronic hemodialysis of 6.7±5.4 years for a median of 65 months. Serum soluble Klotho was detectable in all patients (median 371 pg/mL, interquartile range 309-449). Patients with serum soluble Klotho levels below the lower quartile (

Original languageEnglish (US)
Article number406269
JournalInternational Journal of Endocrinology
Volume2015
DOIs
StatePublished - 2015

Fingerprint

Renal Dialysis
Mortality
Serum
Alternative Splicing
Dialysis
Phenotype
Kidney
Survival
Genes
Proteins

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Otani-Takei, N., Masuda, T., Akimoto, T., Honma, S., Watanabe, Y., Shiizaki, K., ... Nagata, D. (2015). Association between Serum Soluble Klotho Levels and Mortality in Chronic Hemodialysis Patients. International Journal of Endocrinology, 2015, [406269]. https://doi.org/10.1155/2015/406269

Association between Serum Soluble Klotho Levels and Mortality in Chronic Hemodialysis Patients. / Otani-Takei, Naoko; Masuda, Takahiro; Akimoto, Tetsu; Honma, Sumiko; Watanabe, Yuko; Shiizaki, Kazuhiro; Miki, Takuya; Kusano, Eiji; Asano, Yasushi; Kuro-O, Makoto; Nagata, Daisuke.

In: International Journal of Endocrinology, Vol. 2015, 406269, 2015.

Research output: Contribution to journalArticle

Otani-Takei, N, Masuda, T, Akimoto, T, Honma, S, Watanabe, Y, Shiizaki, K, Miki, T, Kusano, E, Asano, Y, Kuro-O, M & Nagata, D 2015, 'Association between Serum Soluble Klotho Levels and Mortality in Chronic Hemodialysis Patients', International Journal of Endocrinology, vol. 2015, 406269. https://doi.org/10.1155/2015/406269
Otani-Takei, Naoko ; Masuda, Takahiro ; Akimoto, Tetsu ; Honma, Sumiko ; Watanabe, Yuko ; Shiizaki, Kazuhiro ; Miki, Takuya ; Kusano, Eiji ; Asano, Yasushi ; Kuro-O, Makoto ; Nagata, Daisuke. / Association between Serum Soluble Klotho Levels and Mortality in Chronic Hemodialysis Patients. In: International Journal of Endocrinology. 2015 ; Vol. 2015.
@article{dac2c82aeec648ab86ea0ac73a5c9c38,
title = "Association between Serum Soluble Klotho Levels and Mortality in Chronic Hemodialysis Patients",
abstract = "Klotho is a single-pass transmembrane protein predominantly expressed in the kidney. The extracellular domain of Klotho is subject to ectodomain shedding and is released into the circulation as a soluble form. Soluble Klotho is also generated from alternative splicing of the Klotho gene. In mice, defects in Klotho expression lead to complex phenotypes resembling those observed in dialysis patients. However, the relationship between the level of serum soluble Klotho and overall survival in hemodialysis patients, who exhibit a state of Klotho deficiency, remains to be delineated. Here we prospectively followed a cohort of 63 patients with a mean duration of chronic hemodialysis of 6.7±5.4 years for a median of 65 months. Serum soluble Klotho was detectable in all patients (median 371 pg/mL, interquartile range 309-449). Patients with serum soluble Klotho levels below the lower quartile (",
author = "Naoko Otani-Takei and Takahiro Masuda and Tetsu Akimoto and Sumiko Honma and Yuko Watanabe and Kazuhiro Shiizaki and Takuya Miki and Eiji Kusano and Yasushi Asano and Makoto Kuro-O and Daisuke Nagata",
year = "2015",
doi = "10.1155/2015/406269",
language = "English (US)",
volume = "2015",
journal = "International Journal of Endocrinology",
issn = "1687-8337",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Association between Serum Soluble Klotho Levels and Mortality in Chronic Hemodialysis Patients

AU - Otani-Takei, Naoko

AU - Masuda, Takahiro

AU - Akimoto, Tetsu

AU - Honma, Sumiko

AU - Watanabe, Yuko

AU - Shiizaki, Kazuhiro

AU - Miki, Takuya

AU - Kusano, Eiji

AU - Asano, Yasushi

AU - Kuro-O, Makoto

AU - Nagata, Daisuke

PY - 2015

Y1 - 2015

N2 - Klotho is a single-pass transmembrane protein predominantly expressed in the kidney. The extracellular domain of Klotho is subject to ectodomain shedding and is released into the circulation as a soluble form. Soluble Klotho is also generated from alternative splicing of the Klotho gene. In mice, defects in Klotho expression lead to complex phenotypes resembling those observed in dialysis patients. However, the relationship between the level of serum soluble Klotho and overall survival in hemodialysis patients, who exhibit a state of Klotho deficiency, remains to be delineated. Here we prospectively followed a cohort of 63 patients with a mean duration of chronic hemodialysis of 6.7±5.4 years for a median of 65 months. Serum soluble Klotho was detectable in all patients (median 371 pg/mL, interquartile range 309-449). Patients with serum soluble Klotho levels below the lower quartile (

AB - Klotho is a single-pass transmembrane protein predominantly expressed in the kidney. The extracellular domain of Klotho is subject to ectodomain shedding and is released into the circulation as a soluble form. Soluble Klotho is also generated from alternative splicing of the Klotho gene. In mice, defects in Klotho expression lead to complex phenotypes resembling those observed in dialysis patients. However, the relationship between the level of serum soluble Klotho and overall survival in hemodialysis patients, who exhibit a state of Klotho deficiency, remains to be delineated. Here we prospectively followed a cohort of 63 patients with a mean duration of chronic hemodialysis of 6.7±5.4 years for a median of 65 months. Serum soluble Klotho was detectable in all patients (median 371 pg/mL, interquartile range 309-449). Patients with serum soluble Klotho levels below the lower quartile (

UR - http://www.scopus.com/inward/record.url?scp=84947589872&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84947589872&partnerID=8YFLogxK

U2 - 10.1155/2015/406269

DO - 10.1155/2015/406269

M3 - Article

VL - 2015

JO - International Journal of Endocrinology

JF - International Journal of Endocrinology

SN - 1687-8337

M1 - 406269

ER -