Association between surgical indications, operative risk, and clinical outcome in infective endocarditis a prospective study from the international collaboration on endocarditis

Vivian H. Chu, Lawrence P. Park, Eugene Athan, Francois Delahaye, Tomas Freiberger, Cristiane Lamas, Jose M. Miro, Daniel W. Mudrick, Jacob Strahilevitz, Christophe Tribouilloy, Emanuele Durante-Mangoni, Juan M. Pericas, Nuria Fernández-Hidalgo, Francisco Nacinovich, Hussien Rizk, Vladimir Krajinovic, Efthymia Giannitsioti, John P. Hurley, Margaret M. Hannan, Andrew WangLiliana Clara, Marisa Sanchez, José Casabé, Claudia Cortes, Pablo Fernandez Oses, Ricardo Ronderos, Adriana Sucari, Jorge Thierer, Javier Altclas, Silvia Kogan, Denis Spelman, Owen Harris, Karina Kennedy, Ren Tan, David Gordon, Tony Korman, Despina Kotsanas, Robyn Dever, Phillip Jones, Pam Konecny, Richard Lawrence, David Rees, Suzanne Ryan, Michael P. Feneley, John Harkness, Jeffrey Post, Porl Reinbott, Rainer Gattringer, Franz Wiesbauer, Adriana Ribas Andrade, Ana Cláudia Passos de Brito, Armenio Costa Guimarães, Max Grinberg, Alfredo José Mansur, Rinaldo Focaccia Siciliano, Tania Mara Varejao Strabelli, Marcelo Luiz Campos Vieira, Regina Aparecida de Medeiros Tranchesi, Marcelo Goulart Paiva, Claudio Querido Fortes, Auristela de Oliveira Ramos, Giovanna Ferraiuoli, Wilma Golebiovski, Clara Weksler, James A. Karlowsky, Yoav Keynan, Andrew M. Morris, Ethan Rubinstein, Sandra Braun Jones, Patricia Garcia, M. Cereceda, Alberto Fica, Ricardo Fernandez, Liliana Franco, Javier Gonzalez, Astrid Natalia Jaramillo, Bruno Barsic, Suzana Bukovski, Igor Rudez, Josip Vincelj, Jiri Pol, Barbora Malisova, Zainab Ashour, Amani El Kholy, Marwa Mishaal, Dina Osama, Neijla Aissa, Corentine Alauzet, Francois Alla, Catherine Campagnac, Thanh Doco-Lecompte, Christine Selton-Suty, Jean Paul Casalta, Pierre Edouard Fournier, Gilbert Habib, Didier Raoult, Franck Thuny, Armelle Delahaye, Francois Vandenesch, Erwan Donal, Pierre Yves Donnio, Erwan Flecher, Christian Michelet, Matthieu Revest, Pierre Tattevin, Florent Chevalier, Antoine Jeu, Jean Paul Rémadi, Dan Rusinaru, Yvette Bernard, Catherine Chirouze, Bruno Hoen, Joel Leroy, Patrick Plesiat, Christoph Naber, Carl Neuerburg, Bahram Mazaheri, Sofia Athanasia, Helen Giamarellou, Tsaganos Thomas, Elena Mylona, Olga Paniara, Konstantinos Papanicolaou, John Pyros, Athanasios Skoutelis, Konstantinos Papanikolaou, Gautam Sharma, Johnson Francis, Lathi Nair, Vinod Thomas, Krishnan Venugopal, Amos Cahan, Dan Gilon, Sarah Israel, Maya Korem, Irene Mattucci, Daniela Pinto, Federica Agrusta, Alessandra Senese, Enrico Ragone, Riccardo Utili, Enrico Cecchi, Francesco De Rosa, Davide Forno, Massimo Imazio, Rita Trinchero, Paolo Grossi, Mariangela Lattanzio, Antonio Toniolo, Antonio Goglio, Annibale Raglio, Veronica Ravasio, Marco Rizzi, Fredy Suter, Giampiero Carosi, Silvia Magri, Liana Signorini, Zeina Kanafani, Souha S. Kanj, Ahmad Sharif-Yakan, Imran Abidin, Syahidah Syed Tamin, Eduardo Rivera Martínez, Gabriel Israel Soto Nieto, Jan T.M. van der Meer, Stephen Chambers, David Holland, Arthur Morris, Nigel Raymond, Kerry Read, David R. Murdoch, Stefan Dragulescu, Adina Ionac, Cristian Mornos, O. M. Butkevich, Natalia Chipigina, Ozerecky Kirill, Kulichenko Vadim, Tatiana Vinogradova, Jameela Edathodu, Magid Halim, Yee Yun Liew, Ru San Tan, Tatjana Lejko-Zupanc, Mateja Logar, Manica Mueller-Premru, Patrick Commerford, Anita Commerford, Eduan Deetlefs, Cass Hansa, Mpiko Ntsekhe, Manuel Almela, Yolanda Armero, Manuel Azqueta, Ximena Castañeda, Carlos Cervera, Carlos Falces, Cristina Garcia-dela-Maria, Guillermina Fita, Jose M. Gatell, Magda Heras, Jaime Llopis, Francesc Marco, Carlos A. Mestres, José M. Miró, Asuncion Moreno, Salvador Ninot, Carlos Paré, Jose Ramirez, Irene Rovira, Marta Sitges, Ignasi Anguera, Bernat Font, Joan Raimon Guma, Javier Bermejo, Emilio Bouza, Miguel Angel Garcia Fernández, Victor Gonzalez-Ramallo, Mercedes Marín, Patricia Muñoz, Miguel Pedromingo, Jorge Roda, Marta Rodríguez-Créixems, Jorge Solis, Benito Almirante, Pilar Tornos, Arístides de Alarcón, Ricardo Parra, Eric Alestig, Magnus Johansson, Lars Olaison, Ulrika Snygg-Martin, Orathai Pachirat, Pimchitra Pachirat, Burabha Pussadhamma, Vichai Senthong, Anna Casey, Tom Elliott, Peter Lambert, Richard Watkin, Christina Eyton, John L. Klein, Suzanne Bradley, Carol Kauffman, Roger J Bedimo, G. Ralph Corey, Anna Lisa Crowley, Pamela Douglas, Laura Drew, Vance G. Fowler, Thomas Holland, Tahaniyat Lalani, Zaniab Samad, Daniel J. Sexton, Martin Stryjewski, Christopher W. Woods, Stamatios Lerakis, Robert Cantey, Lisa Steed, Dannah Wray, Stuart A. Dickerman, Hector Bonilla, Joseph DiPersio, Sara Jane Salstrom, John Baddley, Mukesh Patel, Gail E Peterson, Amy Stancoven, Donald Levine, Jonathan Riddle, Michael Rybak, Christopher H. Cabell, Khaula Baloch, Christy C. Dixon, Tina Harding, Marian Jones-Richmond, Bob Sanderford, Judy Stafford, Kevin Anstrom, Arnold S. Bayer, A. W. Karchmer, David T. Durack, Susannah Eykyn, Phillipe Moreillon

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

Background-Use of surgery for the treatment of infective endocarditis (IE) as related to surgical indications and operative risk for mortality has not been well defined. Methods and Results-The International Collaboration on Endocarditis-PLUS (ICE-PLUS) is a prospective cohort of consecutively enrolled patients with definite IE from 29 centers in 16 countries. We included patients from ICE-PLUS with definite left-sided, non-cardiac device-related IE who were enrolled between September 1, 2008, and December 31, 2012. A total of 1296 patients with left-sided IE were included. Surgical treatment was performed in 57% of the overall cohort and in 76% of patients with a surgical indication. Reasons for nonsurgical treatment included poor prognosis (33.7%), hemodynamic instability (19.8%), death before surgery (23.3%), stroke (22.7%), and sepsis (21%). Among patients with a surgical indication, surgical treatment was independently associated with the presence of severe aortic regurgitation, abscess, embolization before surgical treatment, and transfer from an outside hospital. Variables associated with nonsurgical treatment were a history of moderate/severe liver disease, stroke before surgical decision, and Staphyloccus aureus etiology. The integration of surgical indication, Society of Thoracic Surgeons IE score, and use of surgery was associated with 6-month survival in IE. Conclusions-Surgical decision making in IE is largely consistent with established guidelines, although nearly one quarter of patients with surgical indications do not undergo surgery. Operative risk assessment by Society of Thoracic Surgeons IE score provides prognostic information for survival beyond the operative period. S aureus IE was significantly associated with nonsurgical management.

Original languageEnglish (US)
Pages (from-to)131-140
Number of pages10
JournalCirculation
Volume131
Issue number2
DOIs
StatePublished - Jan 1 2015

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Endocarditis
Prospective Studies
Therapeutics
Stroke
Survival
Aortic Valve Insufficiency
Abscess
Liver Diseases
Sepsis
Decision Making
Hemodynamics
Guidelines
Equipment and Supplies
Mortality

Keywords

  • Endocarditis
  • Infection
  • Mortality
  • Surgery
  • Valve

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Association between surgical indications, operative risk, and clinical outcome in infective endocarditis a prospective study from the international collaboration on endocarditis. / Chu, Vivian H.; Park, Lawrence P.; Athan, Eugene; Delahaye, Francois; Freiberger, Tomas; Lamas, Cristiane; Miro, Jose M.; Mudrick, Daniel W.; Strahilevitz, Jacob; Tribouilloy, Christophe; Durante-Mangoni, Emanuele; Pericas, Juan M.; Fernández-Hidalgo, Nuria; Nacinovich, Francisco; Rizk, Hussien; Krajinovic, Vladimir; Giannitsioti, Efthymia; Hurley, John P.; Hannan, Margaret M.; Wang, Andrew; Clara, Liliana; Sanchez, Marisa; Casabé, José; Cortes, Claudia; Oses, Pablo Fernandez; Ronderos, Ricardo; Sucari, Adriana; Thierer, Jorge; Altclas, Javier; Kogan, Silvia; Spelman, Denis; Harris, Owen; Kennedy, Karina; Tan, Ren; Gordon, David; Korman, Tony; Kotsanas, Despina; Dever, Robyn; Jones, Phillip; Konecny, Pam; Lawrence, Richard; Rees, David; Ryan, Suzanne; Feneley, Michael P.; Harkness, John; Post, Jeffrey; Reinbott, Porl; Gattringer, Rainer; Wiesbauer, Franz; Andrade, Adriana Ribas; de Brito, Ana Cláudia Passos; Guimarães, Armenio Costa; Grinberg, Max; Mansur, Alfredo José; Siciliano, Rinaldo Focaccia; Strabelli, Tania Mara Varejao; Vieira, Marcelo Luiz Campos; de Medeiros Tranchesi, Regina Aparecida; Paiva, Marcelo Goulart; Fortes, Claudio Querido; de Oliveira Ramos, Auristela; Ferraiuoli, Giovanna; Golebiovski, Wilma; Weksler, Clara; Karlowsky, James A.; Keynan, Yoav; Morris, Andrew M.; Rubinstein, Ethan; Jones, Sandra Braun; Garcia, Patricia; Cereceda, M.; Fica, Alberto; Fernandez, Ricardo; Franco, Liliana; Gonzalez, Javier; Jaramillo, Astrid Natalia; Barsic, Bruno; Bukovski, Suzana; Rudez, Igor; Vincelj, Josip; Pol, Jiri; Malisova, Barbora; Ashour, Zainab; El Kholy, Amani; Mishaal, Marwa; Osama, Dina; Aissa, Neijla; Alauzet, Corentine; Alla, Francois; Campagnac, Catherine; Doco-Lecompte, Thanh; Selton-Suty, Christine; Casalta, Jean Paul; Fournier, Pierre Edouard; Habib, Gilbert; Raoult, Didier; Thuny, Franck; Delahaye, Armelle; Vandenesch, Francois; Donal, Erwan; Donnio, Pierre Yves; Flecher, Erwan; Michelet, Christian; Revest, Matthieu; Tattevin, Pierre; Chevalier, Florent; Jeu, Antoine; Rémadi, Jean Paul; Rusinaru, Dan; Bernard, Yvette; Chirouze, Catherine; Hoen, Bruno; Leroy, Joel; Plesiat, Patrick; Naber, Christoph; Neuerburg, Carl; Mazaheri, Bahram; Athanasia, Sofia; Giamarellou, Helen; Thomas, Tsaganos; Mylona, Elena; Paniara, Olga; Papanicolaou, Konstantinos; Pyros, John; Skoutelis, Athanasios; Papanikolaou, Konstantinos; Sharma, Gautam; Francis, Johnson; Nair, Lathi; Thomas, Vinod; Venugopal, Krishnan; Cahan, Amos; Gilon, Dan; Israel, Sarah; Korem, Maya; Mattucci, Irene; Pinto, Daniela; Agrusta, Federica; Senese, Alessandra; Ragone, Enrico; Utili, Riccardo; Cecchi, Enrico; De Rosa, Francesco; Forno, Davide; Imazio, Massimo; Trinchero, Rita; Grossi, Paolo; Lattanzio, Mariangela; Toniolo, Antonio; Goglio, Antonio; Raglio, Annibale; Ravasio, Veronica; Rizzi, Marco; Suter, Fredy; Carosi, Giampiero; Magri, Silvia; Signorini, Liana; Kanafani, Zeina; Kanj, Souha S.; Sharif-Yakan, Ahmad; Abidin, Imran; Tamin, Syahidah Syed; Martínez, Eduardo Rivera; Nieto, Gabriel Israel Soto; van der Meer, Jan T.M.; Chambers, Stephen; Holland, David; Morris, Arthur; Raymond, Nigel; Read, Kerry; Murdoch, David R.; Dragulescu, Stefan; Ionac, Adina; Mornos, Cristian; Butkevich, O. M.; Chipigina, Natalia; Kirill, Ozerecky; Vadim, Kulichenko; Vinogradova, Tatiana; Edathodu, Jameela; Halim, Magid; Liew, Yee Yun; Tan, Ru San; Lejko-Zupanc, Tatjana; Logar, Mateja; Mueller-Premru, Manica; Commerford, Patrick; Commerford, Anita; Deetlefs, Eduan; Hansa, Cass; Ntsekhe, Mpiko; Almela, Manuel; Armero, Yolanda; Azqueta, Manuel; Castañeda, Ximena; Cervera, Carlos; Falces, Carlos; Garcia-dela-Maria, Cristina; Fita, Guillermina; Gatell, Jose M.; Heras, Magda; Llopis, Jaime; Marco, Francesc; Mestres, Carlos A.; Miró, José M.; Moreno, Asuncion; Ninot, Salvador; Paré, Carlos; Ramirez, Jose; Rovira, Irene; Sitges, Marta; Anguera, Ignasi; Font, Bernat; Guma, Joan Raimon; Bermejo, Javier; Bouza, Emilio; Fernández, Miguel Angel Garcia; Gonzalez-Ramallo, Victor; Marín, Mercedes; Muñoz, Patricia; Pedromingo, Miguel; Roda, Jorge; Rodríguez-Créixems, Marta; Solis, Jorge; Almirante, Benito; Tornos, Pilar; de Alarcón, Arístides; Parra, Ricardo; Alestig, Eric; Johansson, Magnus; Olaison, Lars; Snygg-Martin, Ulrika; Pachirat, Orathai; Pachirat, Pimchitra; Pussadhamma, Burabha; Senthong, Vichai; Casey, Anna; Elliott, Tom; Lambert, Peter; Watkin, Richard; Eyton, Christina; Klein, John L.; Bradley, Suzanne; Kauffman, Carol; Bedimo, Roger J; Corey, G. Ralph; Crowley, Anna Lisa; Douglas, Pamela; Drew, Laura; Fowler, Vance G.; Holland, Thomas; Lalani, Tahaniyat; Samad, Zaniab; Sexton, Daniel J.; Stryjewski, Martin; Woods, Christopher W.; Lerakis, Stamatios; Cantey, Robert; Steed, Lisa; Wray, Dannah; Dickerman, Stuart A.; Bonilla, Hector; DiPersio, Joseph; Salstrom, Sara Jane; Baddley, John; Patel, Mukesh; Peterson, Gail E; Stancoven, Amy; Levine, Donald; Riddle, Jonathan; Rybak, Michael; Cabell, Christopher H.; Baloch, Khaula; Dixon, Christy C.; Harding, Tina; Jones-Richmond, Marian; Sanderford, Bob; Stafford, Judy; Anstrom, Kevin; Bayer, Arnold S.; Karchmer, A. W.; Durack, David T.; Eykyn, Susannah; Moreillon, Phillipe.

In: Circulation, Vol. 131, No. 2, 01.01.2015, p. 131-140.

Research output: Contribution to journalArticle

Chu, VH, Park, LP, Athan, E, Delahaye, F, Freiberger, T, Lamas, C, Miro, JM, Mudrick, DW, Strahilevitz, J, Tribouilloy, C, Durante-Mangoni, E, Pericas, JM, Fernández-Hidalgo, N, Nacinovich, F, Rizk, H, Krajinovic, V, Giannitsioti, E, Hurley, JP, Hannan, MM, Wang, A, Clara, L, Sanchez, M, Casabé, J, Cortes, C, Oses, PF, Ronderos, R, Sucari, A, Thierer, J, Altclas, J, Kogan, S, Spelman, D, Harris, O, Kennedy, K, Tan, R, Gordon, D, Korman, T, Kotsanas, D, Dever, R, Jones, P, Konecny, P, Lawrence, R, Rees, D, Ryan, S, Feneley, MP, Harkness, J, Post, J, Reinbott, P, Gattringer, R, Wiesbauer, F, Andrade, AR, de Brito, ACP, Guimarães, AC, Grinberg, M, Mansur, AJ, Siciliano, RF, Strabelli, TMV, Vieira, MLC, de Medeiros Tranchesi, RA, Paiva, MG, Fortes, CQ, de Oliveira Ramos, A, Ferraiuoli, G, Golebiovski, W, Weksler, C, Karlowsky, JA, Keynan, Y, Morris, AM, Rubinstein, E, Jones, SB, Garcia, P, Cereceda, M, Fica, A, Fernandez, R, Franco, L, Gonzalez, J, Jaramillo, AN, Barsic, B, Bukovski, S, Rudez, I, Vincelj, J, Pol, J, Malisova, B, Ashour, Z, El Kholy, A, Mishaal, M, Osama, D, Aissa, N, Alauzet, C, Alla, F, Campagnac, C, Doco-Lecompte, T, Selton-Suty, C, Casalta, JP, Fournier, PE, Habib, G, Raoult, D, Thuny, F, Delahaye, A, Vandenesch, F, Donal, E, Donnio, PY, Flecher, E, Michelet, C, Revest, M, Tattevin, P, Chevalier, F, Jeu, A, Rémadi, JP, Rusinaru, D, Bernard, Y, Chirouze, C, Hoen, B, Leroy, J, Plesiat, P, Naber, C, Neuerburg, C, Mazaheri, B, Athanasia, S, Giamarellou, H, Thomas, T, Mylona, E, Paniara, O, Papanicolaou, K, Pyros, J, Skoutelis, A, Papanikolaou, K, Sharma, G, Francis, J, Nair, L, Thomas, V, Venugopal, K, Cahan, A, Gilon, D, Israel, S, Korem, M, Mattucci, I, Pinto, D, Agrusta, F, Senese, A, Ragone, E, Utili, R, Cecchi, E, De Rosa, F, Forno, D, Imazio, M, Trinchero, R, Grossi, P, Lattanzio, M, Toniolo, A, Goglio, A, Raglio, A, Ravasio, V, Rizzi, M, Suter, F, Carosi, G, Magri, S, Signorini, L, Kanafani, Z, Kanj, SS, Sharif-Yakan, A, Abidin, I, Tamin, SS, Martínez, ER, Nieto, GIS, van der Meer, JTM, Chambers, S, Holland, D, Morris, A, Raymond, N, Read, K, Murdoch, DR, Dragulescu, S, Ionac, A, Mornos, C, Butkevich, OM, Chipigina, N, Kirill, O, Vadim, K, Vinogradova, T, Edathodu, J, Halim, M, Liew, YY, Tan, RS, Lejko-Zupanc, T, Logar, M, Mueller-Premru, M, Commerford, P, Commerford, A, Deetlefs, E, Hansa, C, Ntsekhe, M, Almela, M, Armero, Y, Azqueta, M, Castañeda, X, Cervera, C, Falces, C, Garcia-dela-Maria, C, Fita, G, Gatell, JM, Heras, M, Llopis, J, Marco, F, Mestres, CA, Miró, JM, Moreno, A, Ninot, S, Paré, C, Ramirez, J, Rovira, I, Sitges, M, Anguera, I, Font, B, Guma, JR, Bermejo, J, Bouza, E, Fernández, MAG, Gonzalez-Ramallo, V, Marín, M, Muñoz, P, Pedromingo, M, Roda, J, Rodríguez-Créixems, M, Solis, J, Almirante, B, Tornos, P, de Alarcón, A, Parra, R, Alestig, E, Johansson, M, Olaison, L, Snygg-Martin, U, Pachirat, O, Pachirat, P, Pussadhamma, B, Senthong, V, Casey, A, Elliott, T, Lambert, P, Watkin, R, Eyton, C, Klein, JL, Bradley, S, Kauffman, C, Bedimo, RJ, Corey, GR, Crowley, AL, Douglas, P, Drew, L, Fowler, VG, Holland, T, Lalani, T, Samad, Z, Sexton, DJ, Stryjewski, M, Woods, CW, Lerakis, S, Cantey, R, Steed, L, Wray, D, Dickerman, SA, Bonilla, H, DiPersio, J, Salstrom, SJ, Baddley, J, Patel, M, Peterson, GE, Stancoven, A, Levine, D, Riddle, J, Rybak, M, Cabell, CH, Baloch, K, Dixon, CC, Harding, T, Jones-Richmond, M, Sanderford, B, Stafford, J, Anstrom, K, Bayer, AS, Karchmer, AW, Durack, DT, Eykyn, S & Moreillon, P 2015, 'Association between surgical indications, operative risk, and clinical outcome in infective endocarditis a prospective study from the international collaboration on endocarditis', Circulation, vol. 131, no. 2, pp. 131-140. https://doi.org/10.1161/CIRCULATIONAHA.114.012461
Chu, Vivian H. ; Park, Lawrence P. ; Athan, Eugene ; Delahaye, Francois ; Freiberger, Tomas ; Lamas, Cristiane ; Miro, Jose M. ; Mudrick, Daniel W. ; Strahilevitz, Jacob ; Tribouilloy, Christophe ; Durante-Mangoni, Emanuele ; Pericas, Juan M. ; Fernández-Hidalgo, Nuria ; Nacinovich, Francisco ; Rizk, Hussien ; Krajinovic, Vladimir ; Giannitsioti, Efthymia ; Hurley, John P. ; Hannan, Margaret M. ; Wang, Andrew ; Clara, Liliana ; Sanchez, Marisa ; Casabé, José ; Cortes, Claudia ; Oses, Pablo Fernandez ; Ronderos, Ricardo ; Sucari, Adriana ; Thierer, Jorge ; Altclas, Javier ; Kogan, Silvia ; Spelman, Denis ; Harris, Owen ; Kennedy, Karina ; Tan, Ren ; Gordon, David ; Korman, Tony ; Kotsanas, Despina ; Dever, Robyn ; Jones, Phillip ; Konecny, Pam ; Lawrence, Richard ; Rees, David ; Ryan, Suzanne ; Feneley, Michael P. ; Harkness, John ; Post, Jeffrey ; Reinbott, Porl ; Gattringer, Rainer ; Wiesbauer, Franz ; Andrade, Adriana Ribas ; de Brito, Ana Cláudia Passos ; Guimarães, Armenio Costa ; Grinberg, Max ; Mansur, Alfredo José ; Siciliano, Rinaldo Focaccia ; Strabelli, Tania Mara Varejao ; Vieira, Marcelo Luiz Campos ; de Medeiros Tranchesi, Regina Aparecida ; Paiva, Marcelo Goulart ; Fortes, Claudio Querido ; de Oliveira Ramos, Auristela ; Ferraiuoli, Giovanna ; Golebiovski, Wilma ; Weksler, Clara ; Karlowsky, James A. ; Keynan, Yoav ; Morris, Andrew M. ; Rubinstein, Ethan ; Jones, Sandra Braun ; Garcia, Patricia ; Cereceda, M. ; Fica, Alberto ; Fernandez, Ricardo ; Franco, Liliana ; Gonzalez, Javier ; Jaramillo, Astrid Natalia ; Barsic, Bruno ; Bukovski, Suzana ; Rudez, Igor ; Vincelj, Josip ; Pol, Jiri ; Malisova, Barbora ; Ashour, Zainab ; El Kholy, Amani ; Mishaal, Marwa ; Osama, Dina ; Aissa, Neijla ; Alauzet, Corentine ; Alla, Francois ; Campagnac, Catherine ; Doco-Lecompte, Thanh ; Selton-Suty, Christine ; Casalta, Jean Paul ; Fournier, Pierre Edouard ; Habib, Gilbert ; Raoult, Didier ; Thuny, Franck ; Delahaye, Armelle ; Vandenesch, Francois ; Donal, Erwan ; Donnio, Pierre Yves ; Flecher, Erwan ; Michelet, Christian ; Revest, Matthieu ; Tattevin, Pierre ; Chevalier, Florent ; Jeu, Antoine ; Rémadi, Jean Paul ; Rusinaru, Dan ; Bernard, Yvette ; Chirouze, Catherine ; Hoen, Bruno ; Leroy, Joel ; Plesiat, Patrick ; Naber, Christoph ; Neuerburg, Carl ; Mazaheri, Bahram ; Athanasia, Sofia ; Giamarellou, Helen ; Thomas, Tsaganos ; Mylona, Elena ; Paniara, Olga ; Papanicolaou, Konstantinos ; Pyros, John ; Skoutelis, Athanasios ; Papanikolaou, Konstantinos ; Sharma, Gautam ; Francis, Johnson ; Nair, Lathi ; Thomas, Vinod ; Venugopal, Krishnan ; Cahan, Amos ; Gilon, Dan ; Israel, Sarah ; Korem, Maya ; Mattucci, Irene ; Pinto, Daniela ; Agrusta, Federica ; Senese, Alessandra ; Ragone, Enrico ; Utili, Riccardo ; Cecchi, Enrico ; De Rosa, Francesco ; Forno, Davide ; Imazio, Massimo ; Trinchero, Rita ; Grossi, Paolo ; Lattanzio, Mariangela ; Toniolo, Antonio ; Goglio, Antonio ; Raglio, Annibale ; Ravasio, Veronica ; Rizzi, Marco ; Suter, Fredy ; Carosi, Giampiero ; Magri, Silvia ; Signorini, Liana ; Kanafani, Zeina ; Kanj, Souha S. ; Sharif-Yakan, Ahmad ; Abidin, Imran ; Tamin, Syahidah Syed ; Martínez, Eduardo Rivera ; Nieto, Gabriel Israel Soto ; van der Meer, Jan T.M. ; Chambers, Stephen ; Holland, David ; Morris, Arthur ; Raymond, Nigel ; Read, Kerry ; Murdoch, David R. ; Dragulescu, Stefan ; Ionac, Adina ; Mornos, Cristian ; Butkevich, O. M. ; Chipigina, Natalia ; Kirill, Ozerecky ; Vadim, Kulichenko ; Vinogradova, Tatiana ; Edathodu, Jameela ; Halim, Magid ; Liew, Yee Yun ; Tan, Ru San ; Lejko-Zupanc, Tatjana ; Logar, Mateja ; Mueller-Premru, Manica ; Commerford, Patrick ; Commerford, Anita ; Deetlefs, Eduan ; Hansa, Cass ; Ntsekhe, Mpiko ; Almela, Manuel ; Armero, Yolanda ; Azqueta, Manuel ; Castañeda, Ximena ; Cervera, Carlos ; Falces, Carlos ; Garcia-dela-Maria, Cristina ; Fita, Guillermina ; Gatell, Jose M. ; Heras, Magda ; Llopis, Jaime ; Marco, Francesc ; Mestres, Carlos A. ; Miró, José M. ; Moreno, Asuncion ; Ninot, Salvador ; Paré, Carlos ; Ramirez, Jose ; Rovira, Irene ; Sitges, Marta ; Anguera, Ignasi ; Font, Bernat ; Guma, Joan Raimon ; Bermejo, Javier ; Bouza, Emilio ; Fernández, Miguel Angel Garcia ; Gonzalez-Ramallo, Victor ; Marín, Mercedes ; Muñoz, Patricia ; Pedromingo, Miguel ; Roda, Jorge ; Rodríguez-Créixems, Marta ; Solis, Jorge ; Almirante, Benito ; Tornos, Pilar ; de Alarcón, Arístides ; Parra, Ricardo ; Alestig, Eric ; Johansson, Magnus ; Olaison, Lars ; Snygg-Martin, Ulrika ; Pachirat, Orathai ; Pachirat, Pimchitra ; Pussadhamma, Burabha ; Senthong, Vichai ; Casey, Anna ; Elliott, Tom ; Lambert, Peter ; Watkin, Richard ; Eyton, Christina ; Klein, John L. ; Bradley, Suzanne ; Kauffman, Carol ; Bedimo, Roger J ; Corey, G. Ralph ; Crowley, Anna Lisa ; Douglas, Pamela ; Drew, Laura ; Fowler, Vance G. ; Holland, Thomas ; Lalani, Tahaniyat ; Samad, Zaniab ; Sexton, Daniel J. ; Stryjewski, Martin ; Woods, Christopher W. ; Lerakis, Stamatios ; Cantey, Robert ; Steed, Lisa ; Wray, Dannah ; Dickerman, Stuart A. ; Bonilla, Hector ; DiPersio, Joseph ; Salstrom, Sara Jane ; Baddley, John ; Patel, Mukesh ; Peterson, Gail E ; Stancoven, Amy ; Levine, Donald ; Riddle, Jonathan ; Rybak, Michael ; Cabell, Christopher H. ; Baloch, Khaula ; Dixon, Christy C. ; Harding, Tina ; Jones-Richmond, Marian ; Sanderford, Bob ; Stafford, Judy ; Anstrom, Kevin ; Bayer, Arnold S. ; Karchmer, A. W. ; Durack, David T. ; Eykyn, Susannah ; Moreillon, Phillipe. / Association between surgical indications, operative risk, and clinical outcome in infective endocarditis a prospective study from the international collaboration on endocarditis. In: Circulation. 2015 ; Vol. 131, No. 2. pp. 131-140.
@article{fcdbd8f25f834b6787758d055e7bc35c,
title = "Association between surgical indications, operative risk, and clinical outcome in infective endocarditis a prospective study from the international collaboration on endocarditis",
abstract = "Background-Use of surgery for the treatment of infective endocarditis (IE) as related to surgical indications and operative risk for mortality has not been well defined. Methods and Results-The International Collaboration on Endocarditis-PLUS (ICE-PLUS) is a prospective cohort of consecutively enrolled patients with definite IE from 29 centers in 16 countries. We included patients from ICE-PLUS with definite left-sided, non-cardiac device-related IE who were enrolled between September 1, 2008, and December 31, 2012. A total of 1296 patients with left-sided IE were included. Surgical treatment was performed in 57{\%} of the overall cohort and in 76{\%} of patients with a surgical indication. Reasons for nonsurgical treatment included poor prognosis (33.7{\%}), hemodynamic instability (19.8{\%}), death before surgery (23.3{\%}), stroke (22.7{\%}), and sepsis (21{\%}). Among patients with a surgical indication, surgical treatment was independently associated with the presence of severe aortic regurgitation, abscess, embolization before surgical treatment, and transfer from an outside hospital. Variables associated with nonsurgical treatment were a history of moderate/severe liver disease, stroke before surgical decision, and Staphyloccus aureus etiology. The integration of surgical indication, Society of Thoracic Surgeons IE score, and use of surgery was associated with 6-month survival in IE. Conclusions-Surgical decision making in IE is largely consistent with established guidelines, although nearly one quarter of patients with surgical indications do not undergo surgery. Operative risk assessment by Society of Thoracic Surgeons IE score provides prognostic information for survival beyond the operative period. S aureus IE was significantly associated with nonsurgical management.",
keywords = "Endocarditis, Infection, Mortality, Surgery, Valve",
author = "Chu, {Vivian H.} and Park, {Lawrence P.} and Eugene Athan and Francois Delahaye and Tomas Freiberger and Cristiane Lamas and Miro, {Jose M.} and Mudrick, {Daniel W.} and Jacob Strahilevitz and Christophe Tribouilloy and Emanuele Durante-Mangoni and Pericas, {Juan M.} and Nuria Fern{\'a}ndez-Hidalgo and Francisco Nacinovich and Hussien Rizk and Vladimir Krajinovic and Efthymia Giannitsioti and Hurley, {John P.} and Hannan, {Margaret M.} and Andrew Wang and Liliana Clara and Marisa Sanchez and Jos{\'e} Casab{\'e} and Claudia Cortes and Oses, {Pablo Fernandez} and Ricardo Ronderos and Adriana Sucari and Jorge Thierer and Javier Altclas and Silvia Kogan and Denis Spelman and Owen Harris and Karina Kennedy and Ren Tan and David Gordon and Tony Korman and Despina Kotsanas and Robyn Dever and Phillip Jones and Pam Konecny and Richard Lawrence and David Rees and Suzanne Ryan and Feneley, {Michael P.} and John Harkness and Jeffrey Post and Porl Reinbott and Rainer Gattringer and Franz Wiesbauer and Andrade, {Adriana Ribas} and {de Brito}, {Ana Cl{\'a}udia Passos} and Guimar{\~a}es, {Armenio Costa} and Max Grinberg and Mansur, {Alfredo Jos{\'e}} and Siciliano, {Rinaldo Focaccia} and Strabelli, {Tania Mara Varejao} and Vieira, {Marcelo Luiz Campos} and {de Medeiros Tranchesi}, {Regina Aparecida} and Paiva, {Marcelo Goulart} and Fortes, {Claudio Querido} and {de Oliveira Ramos}, Auristela and Giovanna Ferraiuoli and Wilma Golebiovski and Clara Weksler and Karlowsky, {James A.} and Yoav Keynan and Morris, {Andrew M.} and Ethan Rubinstein and Jones, {Sandra Braun} and Patricia Garcia and M. Cereceda and Alberto Fica and Ricardo Fernandez and Liliana Franco and Javier Gonzalez and Jaramillo, {Astrid Natalia} and Bruno Barsic and Suzana Bukovski and Igor Rudez and Josip Vincelj and Jiri Pol and Barbora Malisova and Zainab Ashour and {El Kholy}, Amani and Marwa Mishaal and Dina Osama and Neijla Aissa and Corentine Alauzet and Francois Alla and Catherine Campagnac and Thanh Doco-Lecompte and Christine Selton-Suty and Casalta, {Jean Paul} and Fournier, {Pierre Edouard} and Gilbert Habib and Didier Raoult and Franck Thuny and Armelle Delahaye and Francois Vandenesch and Erwan Donal and Donnio, {Pierre Yves} and Erwan Flecher and Christian Michelet and Matthieu Revest and Pierre Tattevin and Florent Chevalier and Antoine Jeu and R{\'e}madi, {Jean Paul} and Dan Rusinaru and Yvette Bernard and Catherine Chirouze and Bruno Hoen and Joel Leroy and Patrick Plesiat and Christoph Naber and Carl Neuerburg and Bahram Mazaheri and Sofia Athanasia and Helen Giamarellou and Tsaganos Thomas and Elena Mylona and Olga Paniara and Konstantinos Papanicolaou and John Pyros and Athanasios Skoutelis and Konstantinos Papanikolaou and Gautam Sharma and Johnson Francis and Lathi Nair and Vinod Thomas and Krishnan Venugopal and Amos Cahan and Dan Gilon and Sarah Israel and Maya Korem and Irene Mattucci and Daniela Pinto and Federica Agrusta and Alessandra Senese and Enrico Ragone and Riccardo Utili and Enrico Cecchi and {De Rosa}, Francesco and Davide Forno and Massimo Imazio and Rita Trinchero and Paolo Grossi and Mariangela Lattanzio and Antonio Toniolo and Antonio Goglio and Annibale Raglio and Veronica Ravasio and Marco Rizzi and Fredy Suter and Giampiero Carosi and Silvia Magri and Liana Signorini and Zeina Kanafani and Kanj, {Souha S.} and Ahmad Sharif-Yakan and Imran Abidin and Tamin, {Syahidah Syed} and Mart{\'i}nez, {Eduardo Rivera} and Nieto, {Gabriel Israel Soto} and {van der Meer}, {Jan T.M.} and Stephen Chambers and David Holland and Arthur Morris and Nigel Raymond and Kerry Read and Murdoch, {David R.} and Stefan Dragulescu and Adina Ionac and Cristian Mornos and Butkevich, {O. M.} and Natalia Chipigina and Ozerecky Kirill and Kulichenko Vadim and Tatiana Vinogradova and Jameela Edathodu and Magid Halim and Liew, {Yee Yun} and Tan, {Ru San} and Tatjana Lejko-Zupanc and Mateja Logar and Manica Mueller-Premru and Patrick Commerford and Anita Commerford and Eduan Deetlefs and Cass Hansa and Mpiko Ntsekhe and Manuel Almela and Yolanda Armero and Manuel Azqueta and Ximena Casta{\~n}eda and Carlos Cervera and Carlos Falces and Cristina Garcia-dela-Maria and Guillermina Fita and Gatell, {Jose M.} and Magda Heras and Jaime Llopis and Francesc Marco and Mestres, {Carlos A.} and Mir{\'o}, {Jos{\'e} M.} and Asuncion Moreno and Salvador Ninot and Carlos Par{\'e} and Jose Ramirez and Irene Rovira and Marta Sitges and Ignasi Anguera and Bernat Font and Guma, {Joan Raimon} and Javier Bermejo and Emilio Bouza and Fern{\'a}ndez, {Miguel Angel Garcia} and Victor Gonzalez-Ramallo and Mercedes Mar{\'i}n and Patricia Mu{\~n}oz and Miguel Pedromingo and Jorge Roda and Marta Rodr{\'i}guez-Cr{\'e}ixems and Jorge Solis and Benito Almirante and Pilar Tornos and {de Alarc{\'o}n}, Ar{\'i}stides and Ricardo Parra and Eric Alestig and Magnus Johansson and Lars Olaison and Ulrika Snygg-Martin and Orathai Pachirat and Pimchitra Pachirat and Burabha Pussadhamma and Vichai Senthong and Anna Casey and Tom Elliott and Peter Lambert and Richard Watkin and Christina Eyton and Klein, {John L.} and Suzanne Bradley and Carol Kauffman and Bedimo, {Roger J} and Corey, {G. Ralph} and Crowley, {Anna Lisa} and Pamela Douglas and Laura Drew and Fowler, {Vance G.} and Thomas Holland and Tahaniyat Lalani and Zaniab Samad and Sexton, {Daniel J.} and Martin Stryjewski and Woods, {Christopher W.} and Stamatios Lerakis and Robert Cantey and Lisa Steed and Dannah Wray and Dickerman, {Stuart A.} and Hector Bonilla and Joseph DiPersio and Salstrom, {Sara Jane} and John Baddley and Mukesh Patel and Peterson, {Gail E} and Amy Stancoven and Donald Levine and Jonathan Riddle and Michael Rybak and Cabell, {Christopher H.} and Khaula Baloch and Dixon, {Christy C.} and Tina Harding and Marian Jones-Richmond and Bob Sanderford and Judy Stafford and Kevin Anstrom and Bayer, {Arnold S.} and Karchmer, {A. W.} and Durack, {David T.} and Susannah Eykyn and Phillipe Moreillon",
year = "2015",
month = "1",
day = "1",
doi = "10.1161/CIRCULATIONAHA.114.012461",
language = "English (US)",
volume = "131",
pages = "131--140",
journal = "Circulation",
issn = "0009-7322",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Association between surgical indications, operative risk, and clinical outcome in infective endocarditis a prospective study from the international collaboration on endocarditis

AU - Chu, Vivian H.

AU - Park, Lawrence P.

AU - Athan, Eugene

AU - Delahaye, Francois

AU - Freiberger, Tomas

AU - Lamas, Cristiane

AU - Miro, Jose M.

AU - Mudrick, Daniel W.

AU - Strahilevitz, Jacob

AU - Tribouilloy, Christophe

AU - Durante-Mangoni, Emanuele

AU - Pericas, Juan M.

AU - Fernández-Hidalgo, Nuria

AU - Nacinovich, Francisco

AU - Rizk, Hussien

AU - Krajinovic, Vladimir

AU - Giannitsioti, Efthymia

AU - Hurley, John P.

AU - Hannan, Margaret M.

AU - Wang, Andrew

AU - Clara, Liliana

AU - Sanchez, Marisa

AU - Casabé, José

AU - Cortes, Claudia

AU - Oses, Pablo Fernandez

AU - Ronderos, Ricardo

AU - Sucari, Adriana

AU - Thierer, Jorge

AU - Altclas, Javier

AU - Kogan, Silvia

AU - Spelman, Denis

AU - Harris, Owen

AU - Kennedy, Karina

AU - Tan, Ren

AU - Gordon, David

AU - Korman, Tony

AU - Kotsanas, Despina

AU - Dever, Robyn

AU - Jones, Phillip

AU - Konecny, Pam

AU - Lawrence, Richard

AU - Rees, David

AU - Ryan, Suzanne

AU - Feneley, Michael P.

AU - Harkness, John

AU - Post, Jeffrey

AU - Reinbott, Porl

AU - Gattringer, Rainer

AU - Wiesbauer, Franz

AU - Andrade, Adriana Ribas

AU - de Brito, Ana Cláudia Passos

AU - Guimarães, Armenio Costa

AU - Grinberg, Max

AU - Mansur, Alfredo José

AU - Siciliano, Rinaldo Focaccia

AU - Strabelli, Tania Mara Varejao

AU - Vieira, Marcelo Luiz Campos

AU - de Medeiros Tranchesi, Regina Aparecida

AU - Paiva, Marcelo Goulart

AU - Fortes, Claudio Querido

AU - de Oliveira Ramos, Auristela

AU - Ferraiuoli, Giovanna

AU - Golebiovski, Wilma

AU - Weksler, Clara

AU - Karlowsky, James A.

AU - Keynan, Yoav

AU - Morris, Andrew M.

AU - Rubinstein, Ethan

AU - Jones, Sandra Braun

AU - Garcia, Patricia

AU - Cereceda, M.

AU - Fica, Alberto

AU - Fernandez, Ricardo

AU - Franco, Liliana

AU - Gonzalez, Javier

AU - Jaramillo, Astrid Natalia

AU - Barsic, Bruno

AU - Bukovski, Suzana

AU - Rudez, Igor

AU - Vincelj, Josip

AU - Pol, Jiri

AU - Malisova, Barbora

AU - Ashour, Zainab

AU - El Kholy, Amani

AU - Mishaal, Marwa

AU - Osama, Dina

AU - Aissa, Neijla

AU - Alauzet, Corentine

AU - Alla, Francois

AU - Campagnac, Catherine

AU - Doco-Lecompte, Thanh

AU - Selton-Suty, Christine

AU - Casalta, Jean Paul

AU - Fournier, Pierre Edouard

AU - Habib, Gilbert

AU - Raoult, Didier

AU - Thuny, Franck

AU - Delahaye, Armelle

AU - Vandenesch, Francois

AU - Donal, Erwan

AU - Donnio, Pierre Yves

AU - Flecher, Erwan

AU - Michelet, Christian

AU - Revest, Matthieu

AU - Tattevin, Pierre

AU - Chevalier, Florent

AU - Jeu, Antoine

AU - Rémadi, Jean Paul

AU - Rusinaru, Dan

AU - Bernard, Yvette

AU - Chirouze, Catherine

AU - Hoen, Bruno

AU - Leroy, Joel

AU - Plesiat, Patrick

AU - Naber, Christoph

AU - Neuerburg, Carl

AU - Mazaheri, Bahram

AU - Athanasia, Sofia

AU - Giamarellou, Helen

AU - Thomas, Tsaganos

AU - Mylona, Elena

AU - Paniara, Olga

AU - Papanicolaou, Konstantinos

AU - Pyros, John

AU - Skoutelis, Athanasios

AU - Papanikolaou, Konstantinos

AU - Sharma, Gautam

AU - Francis, Johnson

AU - Nair, Lathi

AU - Thomas, Vinod

AU - Venugopal, Krishnan

AU - Cahan, Amos

AU - Gilon, Dan

AU - Israel, Sarah

AU - Korem, Maya

AU - Mattucci, Irene

AU - Pinto, Daniela

AU - Agrusta, Federica

AU - Senese, Alessandra

AU - Ragone, Enrico

AU - Utili, Riccardo

AU - Cecchi, Enrico

AU - De Rosa, Francesco

AU - Forno, Davide

AU - Imazio, Massimo

AU - Trinchero, Rita

AU - Grossi, Paolo

AU - Lattanzio, Mariangela

AU - Toniolo, Antonio

AU - Goglio, Antonio

AU - Raglio, Annibale

AU - Ravasio, Veronica

AU - Rizzi, Marco

AU - Suter, Fredy

AU - Carosi, Giampiero

AU - Magri, Silvia

AU - Signorini, Liana

AU - Kanafani, Zeina

AU - Kanj, Souha S.

AU - Sharif-Yakan, Ahmad

AU - Abidin, Imran

AU - Tamin, Syahidah Syed

AU - Martínez, Eduardo Rivera

AU - Nieto, Gabriel Israel Soto

AU - van der Meer, Jan T.M.

AU - Chambers, Stephen

AU - Holland, David

AU - Morris, Arthur

AU - Raymond, Nigel

AU - Read, Kerry

AU - Murdoch, David R.

AU - Dragulescu, Stefan

AU - Ionac, Adina

AU - Mornos, Cristian

AU - Butkevich, O. M.

AU - Chipigina, Natalia

AU - Kirill, Ozerecky

AU - Vadim, Kulichenko

AU - Vinogradova, Tatiana

AU - Edathodu, Jameela

AU - Halim, Magid

AU - Liew, Yee Yun

AU - Tan, Ru San

AU - Lejko-Zupanc, Tatjana

AU - Logar, Mateja

AU - Mueller-Premru, Manica

AU - Commerford, Patrick

AU - Commerford, Anita

AU - Deetlefs, Eduan

AU - Hansa, Cass

AU - Ntsekhe, Mpiko

AU - Almela, Manuel

AU - Armero, Yolanda

AU - Azqueta, Manuel

AU - Castañeda, Ximena

AU - Cervera, Carlos

AU - Falces, Carlos

AU - Garcia-dela-Maria, Cristina

AU - Fita, Guillermina

AU - Gatell, Jose M.

AU - Heras, Magda

AU - Llopis, Jaime

AU - Marco, Francesc

AU - Mestres, Carlos A.

AU - Miró, José M.

AU - Moreno, Asuncion

AU - Ninot, Salvador

AU - Paré, Carlos

AU - Ramirez, Jose

AU - Rovira, Irene

AU - Sitges, Marta

AU - Anguera, Ignasi

AU - Font, Bernat

AU - Guma, Joan Raimon

AU - Bermejo, Javier

AU - Bouza, Emilio

AU - Fernández, Miguel Angel Garcia

AU - Gonzalez-Ramallo, Victor

AU - Marín, Mercedes

AU - Muñoz, Patricia

AU - Pedromingo, Miguel

AU - Roda, Jorge

AU - Rodríguez-Créixems, Marta

AU - Solis, Jorge

AU - Almirante, Benito

AU - Tornos, Pilar

AU - de Alarcón, Arístides

AU - Parra, Ricardo

AU - Alestig, Eric

AU - Johansson, Magnus

AU - Olaison, Lars

AU - Snygg-Martin, Ulrika

AU - Pachirat, Orathai

AU - Pachirat, Pimchitra

AU - Pussadhamma, Burabha

AU - Senthong, Vichai

AU - Casey, Anna

AU - Elliott, Tom

AU - Lambert, Peter

AU - Watkin, Richard

AU - Eyton, Christina

AU - Klein, John L.

AU - Bradley, Suzanne

AU - Kauffman, Carol

AU - Bedimo, Roger J

AU - Corey, G. Ralph

AU - Crowley, Anna Lisa

AU - Douglas, Pamela

AU - Drew, Laura

AU - Fowler, Vance G.

AU - Holland, Thomas

AU - Lalani, Tahaniyat

AU - Samad, Zaniab

AU - Sexton, Daniel J.

AU - Stryjewski, Martin

AU - Woods, Christopher W.

AU - Lerakis, Stamatios

AU - Cantey, Robert

AU - Steed, Lisa

AU - Wray, Dannah

AU - Dickerman, Stuart A.

AU - Bonilla, Hector

AU - DiPersio, Joseph

AU - Salstrom, Sara Jane

AU - Baddley, John

AU - Patel, Mukesh

AU - Peterson, Gail E

AU - Stancoven, Amy

AU - Levine, Donald

AU - Riddle, Jonathan

AU - Rybak, Michael

AU - Cabell, Christopher H.

AU - Baloch, Khaula

AU - Dixon, Christy C.

AU - Harding, Tina

AU - Jones-Richmond, Marian

AU - Sanderford, Bob

AU - Stafford, Judy

AU - Anstrom, Kevin

AU - Bayer, Arnold S.

AU - Karchmer, A. W.

AU - Durack, David T.

AU - Eykyn, Susannah

AU - Moreillon, Phillipe

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Background-Use of surgery for the treatment of infective endocarditis (IE) as related to surgical indications and operative risk for mortality has not been well defined. Methods and Results-The International Collaboration on Endocarditis-PLUS (ICE-PLUS) is a prospective cohort of consecutively enrolled patients with definite IE from 29 centers in 16 countries. We included patients from ICE-PLUS with definite left-sided, non-cardiac device-related IE who were enrolled between September 1, 2008, and December 31, 2012. A total of 1296 patients with left-sided IE were included. Surgical treatment was performed in 57% of the overall cohort and in 76% of patients with a surgical indication. Reasons for nonsurgical treatment included poor prognosis (33.7%), hemodynamic instability (19.8%), death before surgery (23.3%), stroke (22.7%), and sepsis (21%). Among patients with a surgical indication, surgical treatment was independently associated with the presence of severe aortic regurgitation, abscess, embolization before surgical treatment, and transfer from an outside hospital. Variables associated with nonsurgical treatment were a history of moderate/severe liver disease, stroke before surgical decision, and Staphyloccus aureus etiology. The integration of surgical indication, Society of Thoracic Surgeons IE score, and use of surgery was associated with 6-month survival in IE. Conclusions-Surgical decision making in IE is largely consistent with established guidelines, although nearly one quarter of patients with surgical indications do not undergo surgery. Operative risk assessment by Society of Thoracic Surgeons IE score provides prognostic information for survival beyond the operative period. S aureus IE was significantly associated with nonsurgical management.

AB - Background-Use of surgery for the treatment of infective endocarditis (IE) as related to surgical indications and operative risk for mortality has not been well defined. Methods and Results-The International Collaboration on Endocarditis-PLUS (ICE-PLUS) is a prospective cohort of consecutively enrolled patients with definite IE from 29 centers in 16 countries. We included patients from ICE-PLUS with definite left-sided, non-cardiac device-related IE who were enrolled between September 1, 2008, and December 31, 2012. A total of 1296 patients with left-sided IE were included. Surgical treatment was performed in 57% of the overall cohort and in 76% of patients with a surgical indication. Reasons for nonsurgical treatment included poor prognosis (33.7%), hemodynamic instability (19.8%), death before surgery (23.3%), stroke (22.7%), and sepsis (21%). Among patients with a surgical indication, surgical treatment was independently associated with the presence of severe aortic regurgitation, abscess, embolization before surgical treatment, and transfer from an outside hospital. Variables associated with nonsurgical treatment were a history of moderate/severe liver disease, stroke before surgical decision, and Staphyloccus aureus etiology. The integration of surgical indication, Society of Thoracic Surgeons IE score, and use of surgery was associated with 6-month survival in IE. Conclusions-Surgical decision making in IE is largely consistent with established guidelines, although nearly one quarter of patients with surgical indications do not undergo surgery. Operative risk assessment by Society of Thoracic Surgeons IE score provides prognostic information for survival beyond the operative period. S aureus IE was significantly associated with nonsurgical management.

KW - Endocarditis

KW - Infection

KW - Mortality

KW - Surgery

KW - Valve

UR - http://www.scopus.com/inward/record.url?scp=84925285609&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84925285609&partnerID=8YFLogxK

U2 - 10.1161/CIRCULATIONAHA.114.012461

DO - 10.1161/CIRCULATIONAHA.114.012461

M3 - Article

C2 - 25480814

AN - SCOPUS:84925285609

VL - 131

SP - 131

EP - 140

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 2

ER -