Association of abnormal serum lipids in elderly persons with atherosclerotic vascular disease and dementia, atherosclerotic vascular disease without dementia, dementia without atherosclerotic vascular disease, and no dementia or atherosclerotic vascular disease

Vana Suryadevara, Samantha G. Storey, Wilbert S. Aronow, Chul Ahn

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16 Citations (Scopus)

Abstract

Background. Observational data have shown that the use of statins was associated with a lower prevalence of vascular dementia and of Alzheimer's disease. Methods. We investigated in an academic nursing home the association of dyslipidemia with atherosclerotic vascular disease (group 1), atherosclerotic vascular disease without dementia (group 2), dementia without atherosclerotic vascular disease (group 3), and no dementia or atherosclerotic vascular disease (group 4). Results. Increased serum low-density lipoprotein (LDL) cholesterol was present in 36 of 50 group 1 patients (72%), in 34 of 50 group 2 patients (68%), in 34 of 50 group 3 patients (68%), and in 18 of 50 group 4 patients (36%) (p =.0003 for 1 versus 4; p = 0.001 for 2 versus 4 and 3 versus 4). Decreased serum high-density lipoprotein (HDL) cholesterol was present in 34 of 50 group 1 patients (68%), in 35 of 50 group 2 patients (70%), in 32 of 50 group 3 patients (64%), and in 16 of 50 group 4 patients (32%) (p = .0003 for 1 versus 4; p = .0001 for 2 versus 4; p = .001 for 3 versus 4). Hypertriglyceridemia was not significantly different in the 4 groups. Conclusions. The prevalence of increased serum LDL cholesterol and decreased serum HDL cholesterol were significantly higher in elderly patients with atherosclerotic vascular disease plus dementia, atherosclerotic vascular disease without dementia, and dementia without atherosclerotic vascular disease than in patients with no dementia or atherosclerotic vascular disease.

Original languageEnglish (US)
Pages (from-to)859-861
Number of pages3
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume58
Issue number9
StatePublished - Sep 1 2003

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Vascular Dementia
Vascular Diseases
Dementia
Lipids
Serum
LDL Cholesterol
HDL Cholesterol
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hypertriglyceridemia
Dyslipidemias
Nursing Homes
Alzheimer Disease

ASJC Scopus subject areas

  • Aging

Cite this

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title = "Association of abnormal serum lipids in elderly persons with atherosclerotic vascular disease and dementia, atherosclerotic vascular disease without dementia, dementia without atherosclerotic vascular disease, and no dementia or atherosclerotic vascular disease",
abstract = "Background. Observational data have shown that the use of statins was associated with a lower prevalence of vascular dementia and of Alzheimer's disease. Methods. We investigated in an academic nursing home the association of dyslipidemia with atherosclerotic vascular disease (group 1), atherosclerotic vascular disease without dementia (group 2), dementia without atherosclerotic vascular disease (group 3), and no dementia or atherosclerotic vascular disease (group 4). Results. Increased serum low-density lipoprotein (LDL) cholesterol was present in 36 of 50 group 1 patients (72{\%}), in 34 of 50 group 2 patients (68{\%}), in 34 of 50 group 3 patients (68{\%}), and in 18 of 50 group 4 patients (36{\%}) (p =.0003 for 1 versus 4; p = 0.001 for 2 versus 4 and 3 versus 4). Decreased serum high-density lipoprotein (HDL) cholesterol was present in 34 of 50 group 1 patients (68{\%}), in 35 of 50 group 2 patients (70{\%}), in 32 of 50 group 3 patients (64{\%}), and in 16 of 50 group 4 patients (32{\%}) (p = .0003 for 1 versus 4; p = .0001 for 2 versus 4; p = .001 for 3 versus 4). Hypertriglyceridemia was not significantly different in the 4 groups. Conclusions. The prevalence of increased serum LDL cholesterol and decreased serum HDL cholesterol were significantly higher in elderly patients with atherosclerotic vascular disease plus dementia, atherosclerotic vascular disease without dementia, and dementia without atherosclerotic vascular disease than in patients with no dementia or atherosclerotic vascular disease.",
author = "Vana Suryadevara and Storey, {Samantha G.} and Aronow, {Wilbert S.} and Chul Ahn",
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T1 - Association of abnormal serum lipids in elderly persons with atherosclerotic vascular disease and dementia, atherosclerotic vascular disease without dementia, dementia without atherosclerotic vascular disease, and no dementia or atherosclerotic vascular disease

AU - Suryadevara, Vana

AU - Storey, Samantha G.

AU - Aronow, Wilbert S.

AU - Ahn, Chul

PY - 2003/9/1

Y1 - 2003/9/1

N2 - Background. Observational data have shown that the use of statins was associated with a lower prevalence of vascular dementia and of Alzheimer's disease. Methods. We investigated in an academic nursing home the association of dyslipidemia with atherosclerotic vascular disease (group 1), atherosclerotic vascular disease without dementia (group 2), dementia without atherosclerotic vascular disease (group 3), and no dementia or atherosclerotic vascular disease (group 4). Results. Increased serum low-density lipoprotein (LDL) cholesterol was present in 36 of 50 group 1 patients (72%), in 34 of 50 group 2 patients (68%), in 34 of 50 group 3 patients (68%), and in 18 of 50 group 4 patients (36%) (p =.0003 for 1 versus 4; p = 0.001 for 2 versus 4 and 3 versus 4). Decreased serum high-density lipoprotein (HDL) cholesterol was present in 34 of 50 group 1 patients (68%), in 35 of 50 group 2 patients (70%), in 32 of 50 group 3 patients (64%), and in 16 of 50 group 4 patients (32%) (p = .0003 for 1 versus 4; p = .0001 for 2 versus 4; p = .001 for 3 versus 4). Hypertriglyceridemia was not significantly different in the 4 groups. Conclusions. The prevalence of increased serum LDL cholesterol and decreased serum HDL cholesterol were significantly higher in elderly patients with atherosclerotic vascular disease plus dementia, atherosclerotic vascular disease without dementia, and dementia without atherosclerotic vascular disease than in patients with no dementia or atherosclerotic vascular disease.

AB - Background. Observational data have shown that the use of statins was associated with a lower prevalence of vascular dementia and of Alzheimer's disease. Methods. We investigated in an academic nursing home the association of dyslipidemia with atherosclerotic vascular disease (group 1), atherosclerotic vascular disease without dementia (group 2), dementia without atherosclerotic vascular disease (group 3), and no dementia or atherosclerotic vascular disease (group 4). Results. Increased serum low-density lipoprotein (LDL) cholesterol was present in 36 of 50 group 1 patients (72%), in 34 of 50 group 2 patients (68%), in 34 of 50 group 3 patients (68%), and in 18 of 50 group 4 patients (36%) (p =.0003 for 1 versus 4; p = 0.001 for 2 versus 4 and 3 versus 4). Decreased serum high-density lipoprotein (HDL) cholesterol was present in 34 of 50 group 1 patients (68%), in 35 of 50 group 2 patients (70%), in 32 of 50 group 3 patients (64%), and in 16 of 50 group 4 patients (32%) (p = .0003 for 1 versus 4; p = .0001 for 2 versus 4; p = .001 for 3 versus 4). Hypertriglyceridemia was not significantly different in the 4 groups. Conclusions. The prevalence of increased serum LDL cholesterol and decreased serum HDL cholesterol were significantly higher in elderly patients with atherosclerotic vascular disease plus dementia, atherosclerotic vascular disease without dementia, and dementia without atherosclerotic vascular disease than in patients with no dementia or atherosclerotic vascular disease.

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