Association of air pollution with increased incidence of ventricular tachyarrhythmias recorded by implanted cardioverter defibrillators

Douglas W. Dockery, Heike Luttman-Gibson, David Q. Rich, Mark S. Link, Murray A. Mittleman, Diane R. Gold, Petros Koutrakis, Joel D. Schwartz, Richard L. Verrier

Research output: Contribution to journalArticle

200 Citations (Scopus)

Abstract

Epidemiologic studies have demonstrated a consistent link between sudden cardiac deaths and particulate air pollution. We used implanted cardioverter defibrillator (ICD) records of ventricular tachyarrhythmias to asses the role of air pollution as a trigger of these potentially life-threatening events. The study cohort consisted of 203 cardiac patients with ICD devices in the Boston metropolitan area who were followed for an average of 3.1 years between 1995 and 2002. Fine particle mass and gaseous air pollution plus temperature and relative humidity were measured on almost all days, and black carbon, sulfate, and particle number on a subset of days. Date, time, and intracardiac electrograms of ICD-detected arrhythmias were downloaded at the patients' regular follow-up visits (about every 3 months). Ventricular tachyarrhythmias were identified by electrophysiologist review. Risk of ventricular arrhythmias associated with air pollution was estimated with logistic regression, adjusting for season, temperature, relative humidity, day of the week, patient, and a recent prior arrhythmia. We found increased risks of ventricular arrhythmias associated with 2-day mean exposure for all air pollutants considered, although these associations were not statistically significant. We found statistically significant associations between air pollution and ventricular arrhythmias for episodes within 3 days of a previous arrhythmia. The associations of ventricular tachyarrhythmias with fine particle mass, carbon monoxide, nitrogen dioxide, and black carbon suggest a link with motor vehicle pollutants. The associations with sulfate suggest a link with stationary fossil fuel combustion sources.

Original languageEnglish (US)
Pages (from-to)670-674
Number of pages5
JournalEnvironmental Health Perspectives
Volume113
Issue number6
DOIs
StatePublished - Jun 1 2005

Fingerprint

Defibrillators
Air Pollution
Tachycardia
Cardiac Arrhythmias
Incidence
Soot
Humidity
Sulfates
Fossil Fuels
Cardiac Electrophysiologic Techniques
Nitrogen Dioxide
Air Pollutants
Temperature
Equidae
Sudden Cardiac Death
Motor Vehicles
Carbon Monoxide
Epidemiologic Studies
Cohort Studies
Logistic Models

Keywords

  • Air pollution
  • Arrythmias
  • Epidemiology
  • Fibrillation
  • Heart arrest

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Association of air pollution with increased incidence of ventricular tachyarrhythmias recorded by implanted cardioverter defibrillators. / Dockery, Douglas W.; Luttman-Gibson, Heike; Rich, David Q.; Link, Mark S.; Mittleman, Murray A.; Gold, Diane R.; Koutrakis, Petros; Schwartz, Joel D.; Verrier, Richard L.

In: Environmental Health Perspectives, Vol. 113, No. 6, 01.06.2005, p. 670-674.

Research output: Contribution to journalArticle

Dockery, DW, Luttman-Gibson, H, Rich, DQ, Link, MS, Mittleman, MA, Gold, DR, Koutrakis, P, Schwartz, JD & Verrier, RL 2005, 'Association of air pollution with increased incidence of ventricular tachyarrhythmias recorded by implanted cardioverter defibrillators', Environmental Health Perspectives, vol. 113, no. 6, pp. 670-674. https://doi.org/10.1289/ehp.7767
Dockery, Douglas W. ; Luttman-Gibson, Heike ; Rich, David Q. ; Link, Mark S. ; Mittleman, Murray A. ; Gold, Diane R. ; Koutrakis, Petros ; Schwartz, Joel D. ; Verrier, Richard L. / Association of air pollution with increased incidence of ventricular tachyarrhythmias recorded by implanted cardioverter defibrillators. In: Environmental Health Perspectives. 2005 ; Vol. 113, No. 6. pp. 670-674.
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