Association of an irregularly shaped anterior choroidal aneurysm with CREST syndrome

Case report

Richard A. Zoumalan, Bernard R. Bendok, Richard J. Parkinson, John Sorin, Allan M. Burke, H. Hunt Batjer

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The authors present the case of a 50-year-old woman with a history of CREST syndrome (calcinosis, Raynaud phenomenon, esophageal motility disorders, sclerodactyly, and telangiectasia), a variant of scleroderma, who was incidentally found to have an irregular intracranial aneurysm. The patient presented with migraine headaches. A magnetic resonance image of the brain obtained during the headache workup revealed a right posterior carotid artery wall aneurysm in the region of the anterior choroidal artery (AChA). On digital subtraction angiograms, the lesion measured 3.5 mm at its largest diameter. Because of the irregular shape of the aneurysm, the patient's relatively young age, and the potential for further aneurysm growth due to collagen disease, surgical clip application was recommended following a discussion of available treatment options. At surgery, the aneurysm was identified as bilobed and broad based, and the AChA was found to be associated with the aneurysm neck. Satisfactory clipping of the aneurysm was achieved with preservation of the parent vessels. An association of CREST syndrome with intracranial aneurysms has only been reported once before. This case is presented to draw attention to the possibility of a pathophysiological connection between CREST syndrome and intracranial aneurysms and to postulate a possible mechanism whereby this condition may result in aneurysm formation. The association of aneurysms with other pathological collagen-related conditions is well known, and literature relevant to a possible connection between CREST syndrome and aneurysms is reviewed and discussed.

Original languageEnglish (US)
Pages (from-to)854-857
Number of pages4
JournalJournal of Neurosurgery
Volume101
Issue number5
StatePublished - Nov 2004

Fingerprint

CREST Syndrome
Aneurysm
Intracranial Aneurysm
Arteries
Esophageal Motility Disorders
Calcinosis
Collagen Diseases
Telangiectasis
Raynaud Disease
Migraine Disorders
Carotid Arteries
Surgical Instruments
Headache
Angiography
Magnetic Resonance Spectroscopy
Collagen

Keywords

  • Aneurysm
  • CREST syndrome
  • Progressive systemic sclerosis
  • Scleroderma

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Zoumalan, R. A., Bendok, B. R., Parkinson, R. J., Sorin, J., Burke, A. M., & Batjer, H. H. (2004). Association of an irregularly shaped anterior choroidal aneurysm with CREST syndrome: Case report. Journal of Neurosurgery, 101(5), 854-857.

Association of an irregularly shaped anterior choroidal aneurysm with CREST syndrome : Case report. / Zoumalan, Richard A.; Bendok, Bernard R.; Parkinson, Richard J.; Sorin, John; Burke, Allan M.; Batjer, H. Hunt.

In: Journal of Neurosurgery, Vol. 101, No. 5, 11.2004, p. 854-857.

Research output: Contribution to journalArticle

Zoumalan, RA, Bendok, BR, Parkinson, RJ, Sorin, J, Burke, AM & Batjer, HH 2004, 'Association of an irregularly shaped anterior choroidal aneurysm with CREST syndrome: Case report', Journal of Neurosurgery, vol. 101, no. 5, pp. 854-857.
Zoumalan, Richard A. ; Bendok, Bernard R. ; Parkinson, Richard J. ; Sorin, John ; Burke, Allan M. ; Batjer, H. Hunt. / Association of an irregularly shaped anterior choroidal aneurysm with CREST syndrome : Case report. In: Journal of Neurosurgery. 2004 ; Vol. 101, No. 5. pp. 854-857.
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