Association of biological markers of alcohol consumption and self-reported drinking with hippocampal volume in a population-based sample of adults

Andrew Naglich, Erin A Van Enkevort, Bryon H Adinoff, Edson S Brown

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Aims: The current study examined a large community cohort to understand relationships between indicators of alcohol consumption and hippocampal volume. Short summary: Alcohol use measures were not associated with hippocampal volume in a population-based sample. However, alcohol consumption was associated with hippocampal volume reduction in subsets of the sample including subjects aged ≥50 years old, and those with none to moderate levels of depressive symptoms. Methods: A total of 1848 adults with magnetic resonance imaging (MRI) and alcohol consumption data were included. Multiple linear regressions were performed with left or right hippocampal volume as dependent variables, and age, gender, race, education, body mass index, Quick Inventory of Depressive Symptomatology (QIDS-SR) scores, drinks per week (DPW), aspartate aminotransferase (AST), alanine aminotransferase (ALT), AST/ALT, γ-glutamyl transferase and mean corpuscular volume (MCV) as independent variables. Post hoc analyses were conducted to assess interactions of demographic factors and variables of interest (DPW, AST, ALT, AST/ALT, GGT and MCV). For statistically significant interactions, analyses were conducted in groups split by gender, depression (QIDS-SR scores ≥11 and <11) and age (≥50 and <50 years). Results: Average alcohol consumption in the population was low (μ = 2.95 ± 6.7 DPW). Alcohol consumption measures were not significantly associated with hippocampal volume in the primary analysis. Exploratory analyses revealed significant associations between DPW and right hippocampal volume in participants with QIDS-SR scores <11 (B = -3.75, P = 0.02, CI = -6.97, -0.52) and in those aged ≥50 years (B = -4.844, P = 0.023 CI = -9.023 to -0.664). AST/ALT was significantly associated with right (B = -93.66, P = 0.022, CI = -173.64 to -13.68) and left hippocampal volume (B = -109.79 P = 0.008, CI = -190.97 to -28.61) in participants aged ≥50 but not <50 years. Gender differences were not observed. Conclusions: The findings suggest a relationship between alcohol use indicators and right hippocampal volume in non-depressed and older adults.

Original languageEnglish (US)
Pages (from-to)539-547
Number of pages9
JournalAlcohol and Alcoholism
Volume53
Issue number5
DOIs
StatePublished - Jan 1 2018

Fingerprint

Aspartate Aminotransferases
Alanine Transaminase
Alcohol Drinking
Drinking
Biomarkers
Alcohols
Erythrocyte Indices
Population
Depression
Transferases
Linear Models
Body Mass Index
Magnetic resonance
Magnetic Resonance Imaging
Demography
Linear regression
Education
Equipment and Supplies
Imaging techniques

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

Cite this

Association of biological markers of alcohol consumption and self-reported drinking with hippocampal volume in a population-based sample of adults. / Naglich, Andrew; Van Enkevort, Erin A; Adinoff, Bryon H; Brown, Edson S.

In: Alcohol and Alcoholism, Vol. 53, No. 5, 01.01.2018, p. 539-547.

Research output: Contribution to journalArticle

@article{e4b38188e2c34e0c8a30c82344e1a995,
title = "Association of biological markers of alcohol consumption and self-reported drinking with hippocampal volume in a population-based sample of adults",
abstract = "Aims: The current study examined a large community cohort to understand relationships between indicators of alcohol consumption and hippocampal volume. Short summary: Alcohol use measures were not associated with hippocampal volume in a population-based sample. However, alcohol consumption was associated with hippocampal volume reduction in subsets of the sample including subjects aged ≥50 years old, and those with none to moderate levels of depressive symptoms. Methods: A total of 1848 adults with magnetic resonance imaging (MRI) and alcohol consumption data were included. Multiple linear regressions were performed with left or right hippocampal volume as dependent variables, and age, gender, race, education, body mass index, Quick Inventory of Depressive Symptomatology (QIDS-SR) scores, drinks per week (DPW), aspartate aminotransferase (AST), alanine aminotransferase (ALT), AST/ALT, γ-glutamyl transferase and mean corpuscular volume (MCV) as independent variables. Post hoc analyses were conducted to assess interactions of demographic factors and variables of interest (DPW, AST, ALT, AST/ALT, GGT and MCV). For statistically significant interactions, analyses were conducted in groups split by gender, depression (QIDS-SR scores ≥11 and <11) and age (≥50 and <50 years). Results: Average alcohol consumption in the population was low (μ = 2.95 ± 6.7 DPW). Alcohol consumption measures were not significantly associated with hippocampal volume in the primary analysis. Exploratory analyses revealed significant associations between DPW and right hippocampal volume in participants with QIDS-SR scores <11 (B = -3.75, P = 0.02, CI = -6.97, -0.52) and in those aged ≥50 years (B = -4.844, P = 0.023 CI = -9.023 to -0.664). AST/ALT was significantly associated with right (B = -93.66, P = 0.022, CI = -173.64 to -13.68) and left hippocampal volume (B = -109.79 P = 0.008, CI = -190.97 to -28.61) in participants aged ≥50 but not <50 years. Gender differences were not observed. Conclusions: The findings suggest a relationship between alcohol use indicators and right hippocampal volume in non-depressed and older adults.",
author = "Andrew Naglich and {Van Enkevort}, {Erin A} and Adinoff, {Bryon H} and Brown, {Edson S}",
year = "2018",
month = "1",
day = "1",
doi = "10.1093/alcalc/agy041",
language = "English (US)",
volume = "53",
pages = "539--547",
journal = "Alcohol and Alcoholism",
issn = "0735-0414",
publisher = "Oxford University Press",
number = "5",

}

TY - JOUR

T1 - Association of biological markers of alcohol consumption and self-reported drinking with hippocampal volume in a population-based sample of adults

AU - Naglich, Andrew

AU - Van Enkevort, Erin A

AU - Adinoff, Bryon H

AU - Brown, Edson S

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Aims: The current study examined a large community cohort to understand relationships between indicators of alcohol consumption and hippocampal volume. Short summary: Alcohol use measures were not associated with hippocampal volume in a population-based sample. However, alcohol consumption was associated with hippocampal volume reduction in subsets of the sample including subjects aged ≥50 years old, and those with none to moderate levels of depressive symptoms. Methods: A total of 1848 adults with magnetic resonance imaging (MRI) and alcohol consumption data were included. Multiple linear regressions were performed with left or right hippocampal volume as dependent variables, and age, gender, race, education, body mass index, Quick Inventory of Depressive Symptomatology (QIDS-SR) scores, drinks per week (DPW), aspartate aminotransferase (AST), alanine aminotransferase (ALT), AST/ALT, γ-glutamyl transferase and mean corpuscular volume (MCV) as independent variables. Post hoc analyses were conducted to assess interactions of demographic factors and variables of interest (DPW, AST, ALT, AST/ALT, GGT and MCV). For statistically significant interactions, analyses were conducted in groups split by gender, depression (QIDS-SR scores ≥11 and <11) and age (≥50 and <50 years). Results: Average alcohol consumption in the population was low (μ = 2.95 ± 6.7 DPW). Alcohol consumption measures were not significantly associated with hippocampal volume in the primary analysis. Exploratory analyses revealed significant associations between DPW and right hippocampal volume in participants with QIDS-SR scores <11 (B = -3.75, P = 0.02, CI = -6.97, -0.52) and in those aged ≥50 years (B = -4.844, P = 0.023 CI = -9.023 to -0.664). AST/ALT was significantly associated with right (B = -93.66, P = 0.022, CI = -173.64 to -13.68) and left hippocampal volume (B = -109.79 P = 0.008, CI = -190.97 to -28.61) in participants aged ≥50 but not <50 years. Gender differences were not observed. Conclusions: The findings suggest a relationship between alcohol use indicators and right hippocampal volume in non-depressed and older adults.

AB - Aims: The current study examined a large community cohort to understand relationships between indicators of alcohol consumption and hippocampal volume. Short summary: Alcohol use measures were not associated with hippocampal volume in a population-based sample. However, alcohol consumption was associated with hippocampal volume reduction in subsets of the sample including subjects aged ≥50 years old, and those with none to moderate levels of depressive symptoms. Methods: A total of 1848 adults with magnetic resonance imaging (MRI) and alcohol consumption data were included. Multiple linear regressions were performed with left or right hippocampal volume as dependent variables, and age, gender, race, education, body mass index, Quick Inventory of Depressive Symptomatology (QIDS-SR) scores, drinks per week (DPW), aspartate aminotransferase (AST), alanine aminotransferase (ALT), AST/ALT, γ-glutamyl transferase and mean corpuscular volume (MCV) as independent variables. Post hoc analyses were conducted to assess interactions of demographic factors and variables of interest (DPW, AST, ALT, AST/ALT, GGT and MCV). For statistically significant interactions, analyses were conducted in groups split by gender, depression (QIDS-SR scores ≥11 and <11) and age (≥50 and <50 years). Results: Average alcohol consumption in the population was low (μ = 2.95 ± 6.7 DPW). Alcohol consumption measures were not significantly associated with hippocampal volume in the primary analysis. Exploratory analyses revealed significant associations between DPW and right hippocampal volume in participants with QIDS-SR scores <11 (B = -3.75, P = 0.02, CI = -6.97, -0.52) and in those aged ≥50 years (B = -4.844, P = 0.023 CI = -9.023 to -0.664). AST/ALT was significantly associated with right (B = -93.66, P = 0.022, CI = -173.64 to -13.68) and left hippocampal volume (B = -109.79 P = 0.008, CI = -190.97 to -28.61) in participants aged ≥50 but not <50 years. Gender differences were not observed. Conclusions: The findings suggest a relationship between alcohol use indicators and right hippocampal volume in non-depressed and older adults.

UR - http://www.scopus.com/inward/record.url?scp=85055146140&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85055146140&partnerID=8YFLogxK

U2 - 10.1093/alcalc/agy041

DO - 10.1093/alcalc/agy041

M3 - Article

C2 - 29931096

AN - SCOPUS:85055146140

VL - 53

SP - 539

EP - 547

JO - Alcohol and Alcoholism

JF - Alcohol and Alcoholism

SN - 0735-0414

IS - 5

ER -