TY - JOUR
T1 - Association of circulating endothelial microparticles with cardiometabolic risk factors in the Framingham Heart Study
AU - Amabile, Nicolas
AU - Cheng, Susan
AU - Renard, Jean Marie
AU - Larson, Martin G.
AU - Ghorbani, Anahita
AU - McCabe, Elizabeth
AU - Griffin, Gabriel
AU - Guerin, Coralie
AU - Ho, Jennifer E.
AU - Shaw, Stanley Y.
AU - Cohen, Kenneth S.
AU - Vasan, Ramachandran S.
AU - Tedgui, Alain
AU - Boulanger, Chantal M.
AU - Wang, Thomas J.
N1 - Publisher Copyright:
© 2014 The Author.
PY - 2014/11/7
Y1 - 2014/11/7
N2 - Objective To examine the relation of endothelial microparticles (EMPs) with cardiometabolic risk in the community.Background Circulating EMPs are small membrane vesicles released after endothelial cell injury. Endothelial microparticles are reportedly increased among individuals with a high burden of cardiovascular risk factors. However, prior investigations have been limited to small, highly selected samples.Methods We studied 844 individuals without a history of cardiovascular disease in the Framingham Offspring cohort (mean age 66 ± 9 years, 57% women). We used standardized flow cytometry methods to identify and quantify circulating CD144+ and CD31+/CD41-EMPs. We then used multivariable regression analyses to investigate the relations of EMP phenotypes with cardiovascular and metabolic risk factors.Results In multivariable analyses, the following cardiovascular risk factors were associated with one or more of the circulating EMP populations: hypertension (P = 0.025 for CD144+,), elevated triglycerides (P = 0.002 for CD144+, P < 0.0001 for CD31+/CD41-), and metabolic syndrome (P < 0.0001 for CD144+,). Overall, each tertile increase in the Framingham risk score corresponded to a 9% increase in log-CD31+/CD41-EMPs (P = 0.022). Furthermore, the presence of hypertriglyceridaemic waist status was associated with 38% higher levels of CD144+ EMPs (P < 0.0001) and 46% higher levels of CD31+/CD41-EMPs (P < 0.0001).Conclusion In a large community-based sample, circulating EMP levels were associated with the presence of cardiometabolic risk factors, particularly dyslipidaemia. These data underscore the potential influence of high-risk metabolic profiles on endothelial integrity.
AB - Objective To examine the relation of endothelial microparticles (EMPs) with cardiometabolic risk in the community.Background Circulating EMPs are small membrane vesicles released after endothelial cell injury. Endothelial microparticles are reportedly increased among individuals with a high burden of cardiovascular risk factors. However, prior investigations have been limited to small, highly selected samples.Methods We studied 844 individuals without a history of cardiovascular disease in the Framingham Offspring cohort (mean age 66 ± 9 years, 57% women). We used standardized flow cytometry methods to identify and quantify circulating CD144+ and CD31+/CD41-EMPs. We then used multivariable regression analyses to investigate the relations of EMP phenotypes with cardiovascular and metabolic risk factors.Results In multivariable analyses, the following cardiovascular risk factors were associated with one or more of the circulating EMP populations: hypertension (P = 0.025 for CD144+,), elevated triglycerides (P = 0.002 for CD144+, P < 0.0001 for CD31+/CD41-), and metabolic syndrome (P < 0.0001 for CD144+,). Overall, each tertile increase in the Framingham risk score corresponded to a 9% increase in log-CD31+/CD41-EMPs (P = 0.022). Furthermore, the presence of hypertriglyceridaemic waist status was associated with 38% higher levels of CD144+ EMPs (P < 0.0001) and 46% higher levels of CD31+/CD41-EMPs (P < 0.0001).Conclusion In a large community-based sample, circulating EMP levels were associated with the presence of cardiometabolic risk factors, particularly dyslipidaemia. These data underscore the potential influence of high-risk metabolic profiles on endothelial integrity.
KW - Cardiovascular risk factors
KW - Endothelium
KW - Microparticles
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U2 - 10.1093/eurheartj/ehu153
DO - 10.1093/eurheartj/ehu153
M3 - Article
C2 - 24742886
AN - SCOPUS:84905639796
SN - 0195-668X
VL - 35
SP - 2972
EP - 2979
JO - European heart journal
JF - European heart journal
IS - 42
ER -