TY - JOUR
T1 - Association of Complete Radiologic and Pathologic Response following Locoregional Therapy before Liver Transplantation with Long-Term Outcomes of Hepatocellular Carcinoma
T2 - A Retrospective Study
AU - Habibollahi, Peiman
AU - Shamchi, Sara Pourhassan
AU - Choi, John M.
AU - Gade, Terence P.
AU - Stavropoulos, S. William
AU - Hunt, Stephen J.
AU - Dagli, Mandeep
AU - Sudheendra, Deepak
AU - Mondschein, Jeffery I.
AU - Soulen, Michael C.
AU - Nadolski, Gregory J.
N1 - Funding Information:
W.S. receives grants from Cook (Bloomington, Indiana) and personal fees from Cook, Bard Peripheral Vascular (Tempe, Arizona), and B. Braun (Melsungen, Germany). M.S. receives grants from Guerbet (Roissy, France) and BTG International (London, United Kingdom) and personal fees from Guerbet, Merit Medical (South Jordan, Utah), Sirtex Medical (North Sydney, Australia), Terumo (Tokyo, Japan), and Bayer/Onyx (South San Francisco, California). G.N. receives grants from Guerbet and Teleflex (Wayne, Pennsylvania) and personal fees from Teleflex. None of the other authors have identified a conflict of interest.
Publisher Copyright:
© 2018 SIR
PY - 2019/3
Y1 - 2019/3
N2 - Purpose: To evaluate long-term outcomes of patients with hepatocellular carcinoma (HCC) who show a complete response (CR) vs non-CR on pretransplantation imaging studies or pathologic evaluation of liver explants after locoregional therapy (LRT) before liver transplantation. Materials and Methods: Patients listed for liver transplantation for HCC (March 1998 to December 2010) undergoing LRT with available multiphase MR/CT imaging before transplantation were included. Pathologic response was evaluated based on liver explant pathology. A total of 108 patients (17 women; 16%) met the inclusion criteria. Results: Radiologic CR was achieved in 65 patients (60%) vs non-CR in 43 (40%), and pathologic CR was achieved in 36 patients (33%) vs non-CR in 72 (67%). Mean 5-year overall survival (OS) from the time of listing and recurrence-free survival (RFS) after liver transplantation were significantly better for patients with pathologic CR vs non-CR on explant pathology (OS, 83.3% vs 65.2% [28% difference; P =.046]; RFS, 80.6% vs 62.5% [29% difference; P =.045]). Mean 5-y OS and RFS were not significantly different between patients with radiologic CR or non-CR on pretransplantation imaging (OS, 75.4% vs 65.1% [P =.12]; RFS, 74% vs 62.8% [P =.17]). Conclusions: Achievement of a pathologic CR vs non-CR in response to LRT before liver transplantation for HCC is associated with improved OS from time of listing and improved RFS after liver transplantation. However, current imaging paradigms fall short of accurate delineation of response to LRT, resulting in poor correlation of outcomes between pathologic and radiologic CR.
AB - Purpose: To evaluate long-term outcomes of patients with hepatocellular carcinoma (HCC) who show a complete response (CR) vs non-CR on pretransplantation imaging studies or pathologic evaluation of liver explants after locoregional therapy (LRT) before liver transplantation. Materials and Methods: Patients listed for liver transplantation for HCC (March 1998 to December 2010) undergoing LRT with available multiphase MR/CT imaging before transplantation were included. Pathologic response was evaluated based on liver explant pathology. A total of 108 patients (17 women; 16%) met the inclusion criteria. Results: Radiologic CR was achieved in 65 patients (60%) vs non-CR in 43 (40%), and pathologic CR was achieved in 36 patients (33%) vs non-CR in 72 (67%). Mean 5-year overall survival (OS) from the time of listing and recurrence-free survival (RFS) after liver transplantation were significantly better for patients with pathologic CR vs non-CR on explant pathology (OS, 83.3% vs 65.2% [28% difference; P =.046]; RFS, 80.6% vs 62.5% [29% difference; P =.045]). Mean 5-y OS and RFS were not significantly different between patients with radiologic CR or non-CR on pretransplantation imaging (OS, 75.4% vs 65.1% [P =.12]; RFS, 74% vs 62.8% [P =.17]). Conclusions: Achievement of a pathologic CR vs non-CR in response to LRT before liver transplantation for HCC is associated with improved OS from time of listing and improved RFS after liver transplantation. However, current imaging paradigms fall short of accurate delineation of response to LRT, resulting in poor correlation of outcomes between pathologic and radiologic CR.
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U2 - 10.1016/j.jvir.2018.11.037
DO - 10.1016/j.jvir.2018.11.037
M3 - Article
C2 - 30819472
AN - SCOPUS:85061970437
SN - 1051-0443
VL - 30
SP - 323
EP - 329
JO - Journal of Vascular and Interventional Radiology
JF - Journal of Vascular and Interventional Radiology
IS - 3
ER -