Association of Concentric Left Ventricular Hypertrophy with Subsequent Change in Left Ventricular End-Diastolic Volume: The Dallas Heart Study

Sonia Garg, James A de Lemos, Susan A Matulevicius, Colby Ayers, Ambarish Pandey, Ian J Neeland, Jarett D Berry, Roderick W McColl, Christopher Maroules, Ronald M Peshock, Mark H Drazner

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Background In the conventional paradigm of the progression of left ventricular hypertrophy, a thick-walled left ventricle (LV) ultimately transitions to a dilated cardiomyopathy. There are scant data in humans demonstrating whether this transition occurs commonly without an interval myocardial infarction. Methods and Results Participants (n=1282) from the Dallas Heart Study underwent serial cardiac magnetic resonance ≈7 years apart. Those with interval cardiovascular events and a dilated LV (increased LV end-diastolic volume [EDV] indexed to body surface area) at baseline were excluded. Multivariable linear regression models tested the association of concentric hypertrophy (increased LV mass and LV mass/volume0.67) with change in LVEDV. The study cohort had a median age of 44 years, 57% women, 43% black, and 11% (n=142) baseline concentric hypertrophy. The change in LVEDV in those with versus without concentric hypertrophy was 1 mL (-9 to 12) versus -2 mL (-11 to 7), respectively, P<0.01. In multivariable linear regression models, concentric hypertrophy was associated with larger follow-up LVEDV (P≤0.01). The progression to a dilated LV was uncommon (2%, n=25). Conclusions In the absence of interval myocardial infarction, concentric hypertrophy was associated with a small, but significantly greater, increase in LVEDV after 7-year follow-up. However, the degree of LV enlargement was minimal, and few participants developed a dilated LV. These data suggest that if concentric hypertrophy does progress to a dilated cardiomyopathy, such a transition would occur over a much longer timeframe (eg, decades) and may be less common than previously thought. Clinical Trial Registration URL: Unique identifier: NCT00344903.

Original languageEnglish (US)
Article numbere003959
JournalCirculation: Heart Failure
Issue number8
StatePublished - Aug 1 2017


  • animals
  • dilation, left ventricular
  • heart
  • hypertrophy, left ventricular

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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