Association of Erythrocyte Aldose Reductase Activity with Diabetic Complications in Type 1 Diabetes Mellitus

Y. Hamada, R. Kitoh, Philip Raskin

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Abstract

Erythrocyte aldose reductase was isolated and its activity measured in 72 Type 1 (insulin dependent) diabetic patients and 21 age and sex matched non‐diabetic subjects. The diabetic patients were categorized into two groups in terms of presence (n = 29) or absence (n = 43) of severe diabetic complications. Age, sex, duration of diabetes and HbA1c levels were matched between the diabetic groups. Erythrocyte aldose reductase (mean ± SEM) was increased in patients with Type 1 diabetes compared to the non‐diabetic subjects (7.22 ± 0.24 vs 5.66 ± 0.19 Ul‐erythrocytes‐1, < 0.0001). There was a four‐fold variation in its activity among the diabetic patients (3.38‐12.23 Ul‐erythrocytes‐1). The enzyme activity was significantly higher in patients with complications than those without (8.17 ± 0.39 vs 6.58 ± 0.26 Ul‐erythrocytes‐1, p < 0.002). When the patients were stratified by duration of the disease, the enzyme activity was highest in patients who had developed complications with a duration of less than 20 years and lowest in those without complications for 20 years or longer (8.54 ± 0.48 vs 6.46 ±p± 0.33 Ul‐erythrocytes‐1, p < 0.002). Patients who had an aldose reductase activity greater than the mean + 2SD of that seen in non‐diabetic controls were four times more likely to have diabetic complications than those whose enzyme activity fell within 2SD of non‐diabetic individuals (p < 0.0005). We conclude that the activity of aldose reductase varies among Type 1 diabetic patients and the differences in its activity may result in a variable susceptibility of these patients to the complications of the disease. 1993 Diabetes UK

Original languageEnglish (US)
Pages (from-to)33-38
Number of pages6
JournalDiabetic Medicine
Volume10
Issue number1
DOIs
StatePublished - Jan 1 1993

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Keywords

  • Diabetic complications
  • Erythrocyte aldose reductase
  • Type 1 diabetes mellitus

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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