Association of extensive polymorphisms in the SLAM/CD2 gene cluster with murine lupus

Amy E. Wandstrat, Charles Nguyen, Nisha Limaye, Alice Y. Chan, Srividya Subramanian, Xiang Hong Tian, Young Sun Yim, Alexander Pertsemlidis, Harold R. Garner, Laurence Morel, Edward K. Wakeland

Research output: Contribution to journalArticlepeer-review

214 Scopus citations

Abstract

Susceptibility to autoimmunity in B6.Sle1b mice is associated with extensive polymorphisms between two divergent haplotypes of the SLAM/CD2 family of genes. The B6.Sle1b-derived SLAM/CD2 family haplotype is found in many other laboratory mouse strains but only causes autoimmunity in the context of the C57Bl/6 (B6) genome. Phenotypic analyses have revealed variations in the structure and expression of several members of the SLAM/CD2 family in T and B lymphocytes from B6.Sle1b mice. T lymphocytes from B6.Sle1b mice have modified signaling responses to stimulation at 4-6 weeks of age. While autoimmunity may be mediated by a combination of genes in the SLAM/CD2 family cluster, the strongest candidate is Ly108, a specific isoform of which is constitutively upregulated in B6.Sle1b lymphocytes.

Original languageEnglish (US)
Pages (from-to)769-780
Number of pages12
JournalImmunity
Volume21
Issue number6
DOIs
StatePublished - Dec 2004

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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