Association of fetal inflammation and coagulation pathway gene polymorphisms with neurodevelopmental delay at age 2 years

Erin A S Clark; Lisa Mele; Ronald J. Wapner; Catherine Y. Spong; Yoram Sorokin; Alan Peaceman; Jay D. Iams; Kenneth J. Leveno; Margaret Harper; Steve N. Caritis; Menachem Miodovnik; Brian M. Mercer; John M. Thorp; Susan M. Ramin; Marshall Carpenter; Dwight J. Rouse

doi:10.1016/j.ajog.2010.01.047

Association of fetal inflammation and coagulation pathway gene polymorphisms with neurodevelopmental delay at age 2 years

Erin A S Clark, Lisa Mele, Ronald J. Wapner, Catherine Y. Spong, Yoram Sorokin, Alan Peaceman, Jay D. Iams, Kenneth J. Leveno, Margaret Harper, Steve N. Caritis, Menachem Miodovnik, Brian M. Mercer, John M. Thorp, Susan M. Ramin, Marshall Carpenter, Dwight J. Rouse

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Objective: The purpose of this study was to evaluate the association between fetal inflammation and coagulation gene single-nucleotide polymorphisms (SNPs) and neurodevelopmental delay at age 2 years. Study Design: We conducted a case-controlled secondary analysis of a randomized trial of single- vs multiple-course corticosteroids. Multiplex assay assessed 46 SNPs. Cases had mental developmental and/or psychomotor delay at age 2 years. Control subjects had normal neurodevelopment. Results: One hundred twenty-five cases and 147 control subjects were analyzed. Allele frequencies were different between cases and control subjects for interleukin (IL)1β-511 (P = .009), IL4R-148 (P = .03), IL6-174 (P = .02), and IL6-176 (P = .007). Genotype frequencies were different for IL1β-511 (P = .03) and IL6-174 (P = .04). Results for IL1β-511, IL4R-148, and IL6-176 remained significant after logistic regression analysis. IL1β-511 and IL6-176 minor alleles were associated with increased risk of neurodevelopmental delay (odds ratio, 3.1; 95% confidence interval [CI], 1.2-8.2 and 2.2; 95% CI, 1.2-3.9, respectively). IL4R-148 minor allele was protective (odds ratio, 0.6; 95% CI, 0.4-0.9). Conclusion: Fetal SNPs in IL1β, IL-4R, and IL-6 may be associated with neurodevelopmental delay at age 2 years.

Original language	English (US)
Pages (from-to)	83.e1-83.e10
Journal	American journal of obstetrics and gynecology
Volume	203
Issue number	1
DOIs	https://doi.org/10.1016/j.ajog.2010.01.047
State	Published - Jul 2010

Keywords

gene polymorphism
neurodevelopmental delay
single-nucleotide polymorphism

ASJC Scopus subject areas

Obstetrics and Gynecology

Access to Document

10.1016/j.ajog.2010.01.047

Cite this

Clark, E. A. S., Mele, L., Wapner, R. J., Spong, C. Y., Sorokin, Y., Peaceman, A., Iams, J. D., Leveno, K. J., Harper, M., Caritis, S. N., Miodovnik, M., Mercer, B. M., Thorp, J. M., Ramin, S. M., Carpenter, M., & Rouse, D. J. (2010). Association of fetal inflammation and coagulation pathway gene polymorphisms with neurodevelopmental delay at age 2 years. American journal of obstetrics and gynecology, 203(1), 83.e1-83.e10. https://doi.org/10.1016/j.ajog.2010.01.047

Clark, EAS, Mele, L, Wapner, RJ, Spong, CY, Sorokin, Y, Peaceman, A, Iams, JD, Leveno, KJ, Harper, M, Caritis, SN, Miodovnik, M, Mercer, BM, Thorp, JM, Ramin, SM, Carpenter, M & Rouse, DJ 2010, 'Association of fetal inflammation and coagulation pathway gene polymorphisms with neurodevelopmental delay at age 2 years', American journal of obstetrics and gynecology, vol. 203, no. 1, pp. 83.e1-83.e10. https://doi.org/10.1016/j.ajog.2010.01.047

@article{08707c591da347fcbe3e5301cb7ab49e,

title = "Association of fetal inflammation and coagulation pathway gene polymorphisms with neurodevelopmental delay at age 2 years",

abstract = "Objective: The purpose of this study was to evaluate the association between fetal inflammation and coagulation gene single-nucleotide polymorphisms (SNPs) and neurodevelopmental delay at age 2 years. Study Design: We conducted a case-controlled secondary analysis of a randomized trial of single- vs multiple-course corticosteroids. Multiplex assay assessed 46 SNPs. Cases had mental developmental and/or psychomotor delay at age 2 years. Control subjects had normal neurodevelopment. Results: One hundred twenty-five cases and 147 control subjects were analyzed. Allele frequencies were different between cases and control subjects for interleukin (IL)1β-511 (P = .009), IL4R-148 (P = .03), IL6-174 (P = .02), and IL6-176 (P = .007). Genotype frequencies were different for IL1β-511 (P = .03) and IL6-174 (P = .04). Results for IL1β-511, IL4R-148, and IL6-176 remained significant after logistic regression analysis. IL1β-511 and IL6-176 minor alleles were associated with increased risk of neurodevelopmental delay (odds ratio, 3.1; 95% confidence interval [CI], 1.2-8.2 and 2.2; 95% CI, 1.2-3.9, respectively). IL4R-148 minor allele was protective (odds ratio, 0.6; 95% CI, 0.4-0.9). Conclusion: Fetal SNPs in IL1β, IL-4R, and IL-6 may be associated with neurodevelopmental delay at age 2 years.",

keywords = "gene polymorphism, neurodevelopmental delay, single-nucleotide polymorphism",

author = "Clark, {Erin A S} and Lisa Mele and Wapner, {Ronald J.} and Spong, {Catherine Y.} and Yoram Sorokin and Alan Peaceman and Iams, {Jay D.} and Leveno, {Kenneth J.} and Margaret Harper and Caritis, {Steve N.} and Menachem Miodovnik and Mercer, {Brian M.} and Thorp, {John M.} and Ramin, {Susan M.} and Marshall Carpenter and Rouse, {Dwight J.}",

note = "Funding Information: Supported by grants from the Eunice Kennedy Shriver National Institute of Child Health and Human Development ( HD21410 , HD27869 , HD27917 , HD27860 , HD27915 , HD34116 , HD34208 , HD34136 , HD40500 , HD40485 , HD40544 , HD40545 , HD40560 , HD40512 , HD40485 , and HD36801 ) and M01-RR-000080 from the National Center for Research Resources . ",

year = "2010",

month = jul,

doi = "10.1016/j.ajog.2010.01.047",

language = "English (US)",

volume = "203",

pages = "83.e1--83.e10",

journal = "American journal of obstetrics and gynecology",

issn = "0002-9378",

publisher = "Mosby Inc.",

number = "1",

}

TY - JOUR

T1 - Association of fetal inflammation and coagulation pathway gene polymorphisms with neurodevelopmental delay at age 2 years

AU - Clark, Erin A S

AU - Mele, Lisa

AU - Wapner, Ronald J.

AU - Spong, Catherine Y.

AU - Sorokin, Yoram

AU - Peaceman, Alan

AU - Iams, Jay D.

AU - Leveno, Kenneth J.

AU - Harper, Margaret

AU - Caritis, Steve N.

AU - Miodovnik, Menachem

AU - Mercer, Brian M.

AU - Thorp, John M.

AU - Ramin, Susan M.

AU - Carpenter, Marshall

AU - Rouse, Dwight J.

N1 - Funding Information: Supported by grants from the Eunice Kennedy Shriver National Institute of Child Health and Human Development ( HD21410 , HD27869 , HD27917 , HD27860 , HD27915 , HD34116 , HD34208 , HD34136 , HD40500 , HD40485 , HD40544 , HD40545 , HD40560 , HD40512 , HD40485 , and HD36801 ) and M01-RR-000080 from the National Center for Research Resources .

PY - 2010/7

Y1 - 2010/7

N2 - Objective: The purpose of this study was to evaluate the association between fetal inflammation and coagulation gene single-nucleotide polymorphisms (SNPs) and neurodevelopmental delay at age 2 years. Study Design: We conducted a case-controlled secondary analysis of a randomized trial of single- vs multiple-course corticosteroids. Multiplex assay assessed 46 SNPs. Cases had mental developmental and/or psychomotor delay at age 2 years. Control subjects had normal neurodevelopment. Results: One hundred twenty-five cases and 147 control subjects were analyzed. Allele frequencies were different between cases and control subjects for interleukin (IL)1β-511 (P = .009), IL4R-148 (P = .03), IL6-174 (P = .02), and IL6-176 (P = .007). Genotype frequencies were different for IL1β-511 (P = .03) and IL6-174 (P = .04). Results for IL1β-511, IL4R-148, and IL6-176 remained significant after logistic regression analysis. IL1β-511 and IL6-176 minor alleles were associated with increased risk of neurodevelopmental delay (odds ratio, 3.1; 95% confidence interval [CI], 1.2-8.2 and 2.2; 95% CI, 1.2-3.9, respectively). IL4R-148 minor allele was protective (odds ratio, 0.6; 95% CI, 0.4-0.9). Conclusion: Fetal SNPs in IL1β, IL-4R, and IL-6 may be associated with neurodevelopmental delay at age 2 years.

AB - Objective: The purpose of this study was to evaluate the association between fetal inflammation and coagulation gene single-nucleotide polymorphisms (SNPs) and neurodevelopmental delay at age 2 years. Study Design: We conducted a case-controlled secondary analysis of a randomized trial of single- vs multiple-course corticosteroids. Multiplex assay assessed 46 SNPs. Cases had mental developmental and/or psychomotor delay at age 2 years. Control subjects had normal neurodevelopment. Results: One hundred twenty-five cases and 147 control subjects were analyzed. Allele frequencies were different between cases and control subjects for interleukin (IL)1β-511 (P = .009), IL4R-148 (P = .03), IL6-174 (P = .02), and IL6-176 (P = .007). Genotype frequencies were different for IL1β-511 (P = .03) and IL6-174 (P = .04). Results for IL1β-511, IL4R-148, and IL6-176 remained significant after logistic regression analysis. IL1β-511 and IL6-176 minor alleles were associated with increased risk of neurodevelopmental delay (odds ratio, 3.1; 95% confidence interval [CI], 1.2-8.2 and 2.2; 95% CI, 1.2-3.9, respectively). IL4R-148 minor allele was protective (odds ratio, 0.6; 95% CI, 0.4-0.9). Conclusion: Fetal SNPs in IL1β, IL-4R, and IL-6 may be associated with neurodevelopmental delay at age 2 years.

KW - gene polymorphism

KW - neurodevelopmental delay

KW - single-nucleotide polymorphism

UR - http://www.scopus.com/inward/record.url?scp=77953917045&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953917045&partnerID=8YFLogxK

U2 - 10.1016/j.ajog.2010.01.047

DO - 10.1016/j.ajog.2010.01.047

M3 - Article

C2 - 20417488

AN - SCOPUS:77953917045

SN - 0002-9378

VL - 203

SP - 83.e1-83.e10

JO - American journal of obstetrics and gynecology

JF - American journal of obstetrics and gynecology

IS - 1

ER -

Association of fetal inflammation and coagulation pathway gene polymorphisms with neurodevelopmental delay at age 2 years

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this