Association of HLA polymorphisms with post-transplant lymphoproliferative disorder in solid-organ transplant recipients

R. Reshef, M. R. Luskin, M. Kamoun, S. Vardhanabhuti, J. E. Tomaszewski, E. A. Stadtmauer, D. L. Porter, D. F. Heitjan, De E. Tsai

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The association between HLA polymorphisms and PTLD was investigated in a case-control study, comparing 110 predominantly adult solid-organ transplant recipients who developed PTLD to 5601 who did not. Donor and recipient HLA were analyzed. We detected a significant association between recipient HLA-A26 and the development of PTLD (OR 2.74; p = 0.0007). In Caucasian recipients, both recipient and donor HLA-A26 were independently associated with development of PTLD (recipient A26 OR 2.99; p = 0.0004, donor A26 OR 2.81; p = 0.002). Analysis of HLA-A and -B haplotypes revealed that recipient HLA-A26, B38 haplotype was strongly correlated with a higher incidence of EBV-positive PTLD (OR 3.99; p = 0.001). The common ancestral haplotype HLA-A1, B8, DR3, when carried by the donor, was protective against PTLD (OR 0.41; p = 0.05). Several other HLA specificities demonstrated associations with clinical and pathological characteristics as well as survival. These findings demonstrate the importance of HLA polymorphisms in modulating the risk for PTLD, and may be useful in risk stratification and development of monitoring and prophylaxis strategies.

Original languageEnglish (US)
Pages (from-to)817-825
Number of pages9
JournalAmerican Journal of Transplantation
Volume11
Issue number4
DOIs
StatePublished - Apr 1 2011

Fingerprint

Lymphoproliferative Disorders
Tissue Donors
Haplotypes
Transplants
faropenem medoxomil
HLA-B38 Antigen
HLA-A1 Antigen
HLA-B8 Antigen
HLA-A Antigens
HLA-B Antigens
Human Herpesvirus 4
Case-Control Studies
Survival
Transplant Recipients
Incidence
HLA-A*26 antigen

Keywords

  • HLA
  • PTLD
  • solid-organ transplantation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

Cite this

Reshef, R., Luskin, M. R., Kamoun, M., Vardhanabhuti, S., Tomaszewski, J. E., Stadtmauer, E. A., ... Tsai, D. E. (2011). Association of HLA polymorphisms with post-transplant lymphoproliferative disorder in solid-organ transplant recipients. American Journal of Transplantation, 11(4), 817-825. https://doi.org/10.1111/j.1600-6143.2011.03454.x

Association of HLA polymorphisms with post-transplant lymphoproliferative disorder in solid-organ transplant recipients. / Reshef, R.; Luskin, M. R.; Kamoun, M.; Vardhanabhuti, S.; Tomaszewski, J. E.; Stadtmauer, E. A.; Porter, D. L.; Heitjan, D. F.; Tsai, De E.

In: American Journal of Transplantation, Vol. 11, No. 4, 01.04.2011, p. 817-825.

Research output: Contribution to journalArticle

Reshef, R, Luskin, MR, Kamoun, M, Vardhanabhuti, S, Tomaszewski, JE, Stadtmauer, EA, Porter, DL, Heitjan, DF & Tsai, DE 2011, 'Association of HLA polymorphisms with post-transplant lymphoproliferative disorder in solid-organ transplant recipients', American Journal of Transplantation, vol. 11, no. 4, pp. 817-825. https://doi.org/10.1111/j.1600-6143.2011.03454.x
Reshef, R. ; Luskin, M. R. ; Kamoun, M. ; Vardhanabhuti, S. ; Tomaszewski, J. E. ; Stadtmauer, E. A. ; Porter, D. L. ; Heitjan, D. F. ; Tsai, De E. / Association of HLA polymorphisms with post-transplant lymphoproliferative disorder in solid-organ transplant recipients. In: American Journal of Transplantation. 2011 ; Vol. 11, No. 4. pp. 817-825.
@article{6be860d3734c45de85d5787eef85455a,
title = "Association of HLA polymorphisms with post-transplant lymphoproliferative disorder in solid-organ transplant recipients",
abstract = "The association between HLA polymorphisms and PTLD was investigated in a case-control study, comparing 110 predominantly adult solid-organ transplant recipients who developed PTLD to 5601 who did not. Donor and recipient HLA were analyzed. We detected a significant association between recipient HLA-A26 and the development of PTLD (OR 2.74; p = 0.0007). In Caucasian recipients, both recipient and donor HLA-A26 were independently associated with development of PTLD (recipient A26 OR 2.99; p = 0.0004, donor A26 OR 2.81; p = 0.002). Analysis of HLA-A and -B haplotypes revealed that recipient HLA-A26, B38 haplotype was strongly correlated with a higher incidence of EBV-positive PTLD (OR 3.99; p = 0.001). The common ancestral haplotype HLA-A1, B8, DR3, when carried by the donor, was protective against PTLD (OR 0.41; p = 0.05). Several other HLA specificities demonstrated associations with clinical and pathological characteristics as well as survival. These findings demonstrate the importance of HLA polymorphisms in modulating the risk for PTLD, and may be useful in risk stratification and development of monitoring and prophylaxis strategies.",
keywords = "HLA, PTLD, solid-organ transplantation",
author = "R. Reshef and Luskin, {M. R.} and M. Kamoun and S. Vardhanabhuti and Tomaszewski, {J. E.} and Stadtmauer, {E. A.} and Porter, {D. L.} and Heitjan, {D. F.} and Tsai, {De E.}",
year = "2011",
month = "4",
day = "1",
doi = "10.1111/j.1600-6143.2011.03454.x",
language = "English (US)",
volume = "11",
pages = "817--825",
journal = "American Journal of Transplantation",
issn = "1600-6135",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Association of HLA polymorphisms with post-transplant lymphoproliferative disorder in solid-organ transplant recipients

AU - Reshef, R.

AU - Luskin, M. R.

AU - Kamoun, M.

AU - Vardhanabhuti, S.

AU - Tomaszewski, J. E.

AU - Stadtmauer, E. A.

AU - Porter, D. L.

AU - Heitjan, D. F.

AU - Tsai, De E.

PY - 2011/4/1

Y1 - 2011/4/1

N2 - The association between HLA polymorphisms and PTLD was investigated in a case-control study, comparing 110 predominantly adult solid-organ transplant recipients who developed PTLD to 5601 who did not. Donor and recipient HLA were analyzed. We detected a significant association between recipient HLA-A26 and the development of PTLD (OR 2.74; p = 0.0007). In Caucasian recipients, both recipient and donor HLA-A26 were independently associated with development of PTLD (recipient A26 OR 2.99; p = 0.0004, donor A26 OR 2.81; p = 0.002). Analysis of HLA-A and -B haplotypes revealed that recipient HLA-A26, B38 haplotype was strongly correlated with a higher incidence of EBV-positive PTLD (OR 3.99; p = 0.001). The common ancestral haplotype HLA-A1, B8, DR3, when carried by the donor, was protective against PTLD (OR 0.41; p = 0.05). Several other HLA specificities demonstrated associations with clinical and pathological characteristics as well as survival. These findings demonstrate the importance of HLA polymorphisms in modulating the risk for PTLD, and may be useful in risk stratification and development of monitoring and prophylaxis strategies.

AB - The association between HLA polymorphisms and PTLD was investigated in a case-control study, comparing 110 predominantly adult solid-organ transplant recipients who developed PTLD to 5601 who did not. Donor and recipient HLA were analyzed. We detected a significant association between recipient HLA-A26 and the development of PTLD (OR 2.74; p = 0.0007). In Caucasian recipients, both recipient and donor HLA-A26 were independently associated with development of PTLD (recipient A26 OR 2.99; p = 0.0004, donor A26 OR 2.81; p = 0.002). Analysis of HLA-A and -B haplotypes revealed that recipient HLA-A26, B38 haplotype was strongly correlated with a higher incidence of EBV-positive PTLD (OR 3.99; p = 0.001). The common ancestral haplotype HLA-A1, B8, DR3, when carried by the donor, was protective against PTLD (OR 0.41; p = 0.05). Several other HLA specificities demonstrated associations with clinical and pathological characteristics as well as survival. These findings demonstrate the importance of HLA polymorphisms in modulating the risk for PTLD, and may be useful in risk stratification and development of monitoring and prophylaxis strategies.

KW - HLA

KW - PTLD

KW - solid-organ transplantation

UR - http://www.scopus.com/inward/record.url?scp=79953236786&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79953236786&partnerID=8YFLogxK

U2 - 10.1111/j.1600-6143.2011.03454.x

DO - 10.1111/j.1600-6143.2011.03454.x

M3 - Article

C2 - 21401872

AN - SCOPUS:79953236786

VL - 11

SP - 817

EP - 825

JO - American Journal of Transplantation

JF - American Journal of Transplantation

SN - 1600-6135

IS - 4

ER -