Association of HLA polymorphisms with post-transplant lymphoproliferative disorder in solid-organ transplant recipients

R. Reshef, M. R. Luskin, M. Kamoun, S. Vardhanabhuti, J. E. Tomaszewski, E. A. Stadtmauer, D. L. Porter, D. F. Heitjan, De E. Tsai

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

The association between HLA polymorphisms and PTLD was investigated in a case-control study, comparing 110 predominantly adult solid-organ transplant recipients who developed PTLD to 5601 who did not. Donor and recipient HLA were analyzed. We detected a significant association between recipient HLA-A26 and the development of PTLD (OR 2.74; p = 0.0007). In Caucasian recipients, both recipient and donor HLA-A26 were independently associated with development of PTLD (recipient A26 OR 2.99; p = 0.0004, donor A26 OR 2.81; p = 0.002). Analysis of HLA-A and -B haplotypes revealed that recipient HLA-A26, B38 haplotype was strongly correlated with a higher incidence of EBV-positive PTLD (OR 3.99; p = 0.001). The common ancestral haplotype HLA-A1, B8, DR3, when carried by the donor, was protective against PTLD (OR 0.41; p = 0.05). Several other HLA specificities demonstrated associations with clinical and pathological characteristics as well as survival. These findings demonstrate the importance of HLA polymorphisms in modulating the risk for PTLD, and may be useful in risk stratification and development of monitoring and prophylaxis strategies.

Original languageEnglish (US)
Pages (from-to)817-825
Number of pages9
JournalAmerican Journal of Transplantation
Volume11
Issue number4
DOIs
StatePublished - Apr 1 2011

Keywords

  • HLA
  • PTLD
  • solid-organ transplantation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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    Reshef, R., Luskin, M. R., Kamoun, M., Vardhanabhuti, S., Tomaszewski, J. E., Stadtmauer, E. A., Porter, D. L., Heitjan, D. F., & Tsai, D. E. (2011). Association of HLA polymorphisms with post-transplant lymphoproliferative disorder in solid-organ transplant recipients. American Journal of Transplantation, 11(4), 817-825. https://doi.org/10.1111/j.1600-6143.2011.03454.x