Association of hospital performance based on 30-day risk-standardized mortality rate with long-term survival after heart failure hospitalization. An analysis of the get with the guidelines-heart failure registry

Ambarish Pandey, Kershaw V. Patel, Li Liang, Adam D. DeVore, Roland Matsouaka, Deepak L. Bhatt, Clyde W. Yancy, Adrian F. Hernandez, Paul A. Heidenreich, James A de Lemos, Gregg C. Fonarow

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

IMPORTANCE Among patients hospitalized with heart failure (HF), the long-term clinical implications of hospitalization at hospitals based on 30-day risk-standardized mortality rates (RSMRs) is not known. OBJECTIVE To evaluate the association of hospital-specific 30-day RSMR with long-term survival among patients hospitalized with HF in the American Heart Association Get With The Guidelines-HF registry. DESIGN, SETTING, AND PARTICIPANTS The longitudinal observational study included 106 304 patients with HF who were admitted to 317 centers participating in the Get With The Guidelines-HF registry from January 1, 2005, to December 31, 2013, and had Medicare-linked follow-up data. Hospital-specific 30-day RSMR was calculated using a hierarchical logistic regression model. In the model, 30-day mortality rate was a binary outcome, patient baseline characteristics were included as covariates, and the hospitals were treated as random effects. The association of 30-day RSMR-based hospital groups (low to high 30-day RSMR: quartile 1 [Q1] to Q4) with long-term (1-year, 3-year, and 5-year) mortality was assessed using adjusted Cox models. Data analysis took place from June 29, 2017, to February 19, 2018. EXPOSURES Thirty-day RSMR for participating hospitals. MAIN OUTCOMES AND MEASURES One-year, 3-year, and 5-year mortality rates. RESULTS Of the 106 304 patients included in the analysis, 57 552 (54.1%) were women and 84 595 (79.6%) were white, and the median (interquartile range) age was 81 (74-87) years. The 30-day RSMR ranged from 8.6%(Q1) to 10.7%(Q4). Hospitals in the low 30-day RSMR group had greater availability of advanced HF therapies, cardiac surgery, and percutaneous coronary interventions. In the primary landmarked analyses among 30-day survivors, there was a graded inverse association between 30-day RSMR and long-term mortality (Q1 vs Q4: 5-year mortality, 73.7%vs 76.8%). In adjusted analysis, patients admitted to hospitals in the high 30-day RSMR group had 14%(95%CI, 10-18) higher relative hazards of 5-year mortality compared with those admitted to hospitals in the low 30-day RSMR group. Similar findings were observed in analyses of survival from admission, with 22%(95%CI, 18-26) higher relative hazards of 5-year mortality for patients admitted to Q4 vs Q1 hospitals. CONCLUSIONS AND RELEVANCE Lower hospital-level 30-day RSMR is associated with greater 1-year, 3-year, and 5-year survival for patients with HF. These differences in 30-day survival continued to accrue beyond 30 days and persisted long term, suggesting that 30-day RSMR may be a useful HF performance metric to incentivize quality care and improve long-term outcomes.

Original languageEnglish (US)
Pages (from-to)489-497
Number of pages9
JournalJAMA Cardiology
Volume3
Issue number6
DOIs
StatePublished - Jun 2018

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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