Association of hospital performance based on 30-day risk-standardized mortality rate with long-term survival after heart failure hospitalization. An analysis of the get with the guidelines-heart failure registry

Ambarish Pandey, Kershaw V. Patel, Li Liang, Adam D. DeVore, Roland Matsouaka, Deepak L. Bhatt, Clyde W. Yancy, Adrian F. Hernandez, Paul A. Heidenreich, James A de Lemos, Gregg C. Fonarow

Research output: Contribution to journalArticle

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Abstract

IMPORTANCE Among patients hospitalized with heart failure (HF), the long-term clinical implications of hospitalization at hospitals based on 30-day risk-standardized mortality rates (RSMRs) is not known. OBJECTIVE To evaluate the association of hospital-specific 30-day RSMR with long-term survival among patients hospitalized with HF in the American Heart Association Get With The Guidelines-HF registry. DESIGN, SETTING, AND PARTICIPANTS The longitudinal observational study included 106 304 patients with HF who were admitted to 317 centers participating in the Get With The Guidelines-HF registry from January 1, 2005, to December 31, 2013, and had Medicare-linked follow-up data. Hospital-specific 30-day RSMR was calculated using a hierarchical logistic regression model. In the model, 30-day mortality rate was a binary outcome, patient baseline characteristics were included as covariates, and the hospitals were treated as random effects. The association of 30-day RSMR-based hospital groups (low to high 30-day RSMR: quartile 1 [Q1] to Q4) with long-term (1-year, 3-year, and 5-year) mortality was assessed using adjusted Cox models. Data analysis took place from June 29, 2017, to February 19, 2018. EXPOSURES Thirty-day RSMR for participating hospitals. MAIN OUTCOMES AND MEASURES One-year, 3-year, and 5-year mortality rates. RESULTS Of the 106 304 patients included in the analysis, 57 552 (54.1%) were women and 84 595 (79.6%) were white, and the median (interquartile range) age was 81 (74-87) years. The 30-day RSMR ranged from 8.6%(Q1) to 10.7%(Q4). Hospitals in the low 30-day RSMR group had greater availability of advanced HF therapies, cardiac surgery, and percutaneous coronary interventions. In the primary landmarked analyses among 30-day survivors, there was a graded inverse association between 30-day RSMR and long-term mortality (Q1 vs Q4: 5-year mortality, 73.7%vs 76.8%). In adjusted analysis, patients admitted to hospitals in the high 30-day RSMR group had 14%(95%CI, 10-18) higher relative hazards of 5-year mortality compared with those admitted to hospitals in the low 30-day RSMR group. Similar findings were observed in analyses of survival from admission, with 22%(95%CI, 18-26) higher relative hazards of 5-year mortality for patients admitted to Q4 vs Q1 hospitals. CONCLUSIONS AND RELEVANCE Lower hospital-level 30-day RSMR is associated with greater 1-year, 3-year, and 5-year survival for patients with HF. These differences in 30-day survival continued to accrue beyond 30 days and persisted long term, suggesting that 30-day RSMR may be a useful HF performance metric to incentivize quality care and improve long-term outcomes.

Original languageEnglish (US)
Pages (from-to)489-497
Number of pages9
JournalJAMA Cardiology
Volume3
Issue number6
DOIs
StatePublished - Jun 1 2018

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Registries
Hospitalization
Heart Failure
Guidelines
Survival
Mortality
Logistic Models
Quality of Health Care
Percutaneous Coronary Intervention
Survival Analysis
Medicare
Proportional Hazards Models
Thoracic Surgery
Observational Studies
Longitudinal Studies
Survivors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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Association of hospital performance based on 30-day risk-standardized mortality rate with long-term survival after heart failure hospitalization. An analysis of the get with the guidelines-heart failure registry. / Pandey, Ambarish; Patel, Kershaw V.; Liang, Li; DeVore, Adam D.; Matsouaka, Roland; Bhatt, Deepak L.; Yancy, Clyde W.; Hernandez, Adrian F.; Heidenreich, Paul A.; de Lemos, James A; Fonarow, Gregg C.

In: JAMA Cardiology, Vol. 3, No. 6, 01.06.2018, p. 489-497.

Research output: Contribution to journalArticle

Pandey, Ambarish ; Patel, Kershaw V. ; Liang, Li ; DeVore, Adam D. ; Matsouaka, Roland ; Bhatt, Deepak L. ; Yancy, Clyde W. ; Hernandez, Adrian F. ; Heidenreich, Paul A. ; de Lemos, James A ; Fonarow, Gregg C. / Association of hospital performance based on 30-day risk-standardized mortality rate with long-term survival after heart failure hospitalization. An analysis of the get with the guidelines-heart failure registry. In: JAMA Cardiology. 2018 ; Vol. 3, No. 6. pp. 489-497.
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abstract = "IMPORTANCE Among patients hospitalized with heart failure (HF), the long-term clinical implications of hospitalization at hospitals based on 30-day risk-standardized mortality rates (RSMRs) is not known. OBJECTIVE To evaluate the association of hospital-specific 30-day RSMR with long-term survival among patients hospitalized with HF in the American Heart Association Get With The Guidelines-HF registry. DESIGN, SETTING, AND PARTICIPANTS The longitudinal observational study included 106 304 patients with HF who were admitted to 317 centers participating in the Get With The Guidelines-HF registry from January 1, 2005, to December 31, 2013, and had Medicare-linked follow-up data. Hospital-specific 30-day RSMR was calculated using a hierarchical logistic regression model. In the model, 30-day mortality rate was a binary outcome, patient baseline characteristics were included as covariates, and the hospitals were treated as random effects. The association of 30-day RSMR-based hospital groups (low to high 30-day RSMR: quartile 1 [Q1] to Q4) with long-term (1-year, 3-year, and 5-year) mortality was assessed using adjusted Cox models. Data analysis took place from June 29, 2017, to February 19, 2018. EXPOSURES Thirty-day RSMR for participating hospitals. MAIN OUTCOMES AND MEASURES One-year, 3-year, and 5-year mortality rates. RESULTS Of the 106 304 patients included in the analysis, 57 552 (54.1{\%}) were women and 84 595 (79.6{\%}) were white, and the median (interquartile range) age was 81 (74-87) years. The 30-day RSMR ranged from 8.6{\%}(Q1) to 10.7{\%}(Q4). Hospitals in the low 30-day RSMR group had greater availability of advanced HF therapies, cardiac surgery, and percutaneous coronary interventions. In the primary landmarked analyses among 30-day survivors, there was a graded inverse association between 30-day RSMR and long-term mortality (Q1 vs Q4: 5-year mortality, 73.7{\%}vs 76.8{\%}). In adjusted analysis, patients admitted to hospitals in the high 30-day RSMR group had 14{\%}(95{\%}CI, 10-18) higher relative hazards of 5-year mortality compared with those admitted to hospitals in the low 30-day RSMR group. Similar findings were observed in analyses of survival from admission, with 22{\%}(95{\%}CI, 18-26) higher relative hazards of 5-year mortality for patients admitted to Q4 vs Q1 hospitals. CONCLUSIONS AND RELEVANCE Lower hospital-level 30-day RSMR is associated with greater 1-year, 3-year, and 5-year survival for patients with HF. These differences in 30-day survival continued to accrue beyond 30 days and persisted long term, suggesting that 30-day RSMR may be a useful HF performance metric to incentivize quality care and improve long-term outcomes.",
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T1 - Association of hospital performance based on 30-day risk-standardized mortality rate with long-term survival after heart failure hospitalization. An analysis of the get with the guidelines-heart failure registry

AU - Pandey, Ambarish

AU - Patel, Kershaw V.

AU - Liang, Li

AU - DeVore, Adam D.

AU - Matsouaka, Roland

AU - Bhatt, Deepak L.

AU - Yancy, Clyde W.

AU - Hernandez, Adrian F.

AU - Heidenreich, Paul A.

AU - de Lemos, James A

AU - Fonarow, Gregg C.

PY - 2018/6/1

Y1 - 2018/6/1

N2 - IMPORTANCE Among patients hospitalized with heart failure (HF), the long-term clinical implications of hospitalization at hospitals based on 30-day risk-standardized mortality rates (RSMRs) is not known. OBJECTIVE To evaluate the association of hospital-specific 30-day RSMR with long-term survival among patients hospitalized with HF in the American Heart Association Get With The Guidelines-HF registry. DESIGN, SETTING, AND PARTICIPANTS The longitudinal observational study included 106 304 patients with HF who were admitted to 317 centers participating in the Get With The Guidelines-HF registry from January 1, 2005, to December 31, 2013, and had Medicare-linked follow-up data. Hospital-specific 30-day RSMR was calculated using a hierarchical logistic regression model. In the model, 30-day mortality rate was a binary outcome, patient baseline characteristics were included as covariates, and the hospitals were treated as random effects. The association of 30-day RSMR-based hospital groups (low to high 30-day RSMR: quartile 1 [Q1] to Q4) with long-term (1-year, 3-year, and 5-year) mortality was assessed using adjusted Cox models. Data analysis took place from June 29, 2017, to February 19, 2018. EXPOSURES Thirty-day RSMR for participating hospitals. MAIN OUTCOMES AND MEASURES One-year, 3-year, and 5-year mortality rates. RESULTS Of the 106 304 patients included in the analysis, 57 552 (54.1%) were women and 84 595 (79.6%) were white, and the median (interquartile range) age was 81 (74-87) years. The 30-day RSMR ranged from 8.6%(Q1) to 10.7%(Q4). Hospitals in the low 30-day RSMR group had greater availability of advanced HF therapies, cardiac surgery, and percutaneous coronary interventions. In the primary landmarked analyses among 30-day survivors, there was a graded inverse association between 30-day RSMR and long-term mortality (Q1 vs Q4: 5-year mortality, 73.7%vs 76.8%). In adjusted analysis, patients admitted to hospitals in the high 30-day RSMR group had 14%(95%CI, 10-18) higher relative hazards of 5-year mortality compared with those admitted to hospitals in the low 30-day RSMR group. Similar findings were observed in analyses of survival from admission, with 22%(95%CI, 18-26) higher relative hazards of 5-year mortality for patients admitted to Q4 vs Q1 hospitals. CONCLUSIONS AND RELEVANCE Lower hospital-level 30-day RSMR is associated with greater 1-year, 3-year, and 5-year survival for patients with HF. These differences in 30-day survival continued to accrue beyond 30 days and persisted long term, suggesting that 30-day RSMR may be a useful HF performance metric to incentivize quality care and improve long-term outcomes.

AB - IMPORTANCE Among patients hospitalized with heart failure (HF), the long-term clinical implications of hospitalization at hospitals based on 30-day risk-standardized mortality rates (RSMRs) is not known. OBJECTIVE To evaluate the association of hospital-specific 30-day RSMR with long-term survival among patients hospitalized with HF in the American Heart Association Get With The Guidelines-HF registry. DESIGN, SETTING, AND PARTICIPANTS The longitudinal observational study included 106 304 patients with HF who were admitted to 317 centers participating in the Get With The Guidelines-HF registry from January 1, 2005, to December 31, 2013, and had Medicare-linked follow-up data. Hospital-specific 30-day RSMR was calculated using a hierarchical logistic regression model. In the model, 30-day mortality rate was a binary outcome, patient baseline characteristics were included as covariates, and the hospitals were treated as random effects. The association of 30-day RSMR-based hospital groups (low to high 30-day RSMR: quartile 1 [Q1] to Q4) with long-term (1-year, 3-year, and 5-year) mortality was assessed using adjusted Cox models. Data analysis took place from June 29, 2017, to February 19, 2018. EXPOSURES Thirty-day RSMR for participating hospitals. MAIN OUTCOMES AND MEASURES One-year, 3-year, and 5-year mortality rates. RESULTS Of the 106 304 patients included in the analysis, 57 552 (54.1%) were women and 84 595 (79.6%) were white, and the median (interquartile range) age was 81 (74-87) years. The 30-day RSMR ranged from 8.6%(Q1) to 10.7%(Q4). Hospitals in the low 30-day RSMR group had greater availability of advanced HF therapies, cardiac surgery, and percutaneous coronary interventions. In the primary landmarked analyses among 30-day survivors, there was a graded inverse association between 30-day RSMR and long-term mortality (Q1 vs Q4: 5-year mortality, 73.7%vs 76.8%). In adjusted analysis, patients admitted to hospitals in the high 30-day RSMR group had 14%(95%CI, 10-18) higher relative hazards of 5-year mortality compared with those admitted to hospitals in the low 30-day RSMR group. Similar findings were observed in analyses of survival from admission, with 22%(95%CI, 18-26) higher relative hazards of 5-year mortality for patients admitted to Q4 vs Q1 hospitals. CONCLUSIONS AND RELEVANCE Lower hospital-level 30-day RSMR is associated with greater 1-year, 3-year, and 5-year survival for patients with HF. These differences in 30-day survival continued to accrue beyond 30 days and persisted long term, suggesting that 30-day RSMR may be a useful HF performance metric to incentivize quality care and improve long-term outcomes.

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