TY - JOUR
T1 - Association of leukocyte telomere length with circulating biomarkers of the renin-angiotensin-aldosterone system
T2 - The Framingham heart study
AU - Vasan, Ramachandran S.
AU - Demissie, Serkalem
AU - Kimura, Masayuki
AU - Cupples, L. Adrienne
AU - Rifai, Nader
AU - White, Charles
AU - Wang, Thomas J.
AU - Gardner, Jeffrey P.
AU - Cao, Xiaogian
AU - Benjamin, Emelia J.
AU - Levy, Daniel
AU - Aviv, Abraham
PY - 2008/3
Y1 - 2008/3
N2 - BACKGROUND - Leukocyte telomere length (LTL) chronicles the cumulative burden of oxidative stress and inflammation over a life course. Activation of the renin-angiotensin-aldosterone system is associated with increased oxidative stress and inflammation. Therefore, LTL may be related to circulating biomarkers of the renin-angiotensin-aldosterone system. METHODS AND RESULTS - We evaluated the cross-sectional relations of LTL (dependent variable) to circulating renin and aldosterone concentrations and the renin-to-aldosterone ratio (all logarithmically transformed; independent variables) in 1203 Framingham Study participants (mean age, 59 years; 51% women). We used multivariable linear regression and adjusted for age, blood pressure, hypertension treatment, smoking, diabetes mellitus, body mass index, hormone replacement therapy, serum creatinine, and the urine sodium-to-creatinine ratio. Overall, multivariable-adjusted LTL was inversely related to renin (β coefficient per unit increase, -0.038; P=0.036), directly related to aldosterone (β=0.099; P=0.002), and inversely related to the renin-to-aldosterone ratio (β=-0.049; P=0.003). Relations of LTL to biomarkers were stronger in those with hypertension, although a formal test of interaction was not statistically significant (P=0.20). Individuals with hypertension displayed significant associations of LTL with renin (β=-0.060; P=0.005), aldosterone (β=0.134; P=0.002), and renin-to-aldosterone ratio (β=-0.072; P<0.001). Participants with hypertension who were in the top tertile of the renin-to-aldosterone ratio had LTL that was 182 base pairs shorter relative to those in the lowest tertile. CONCLUSIONS - In our community-based sample, LTL was shorter in individuals with a higher renin-to-aldosterone ratio, especially in participants with hypertension. Additional investigations are warranted to confirm our observations.
AB - BACKGROUND - Leukocyte telomere length (LTL) chronicles the cumulative burden of oxidative stress and inflammation over a life course. Activation of the renin-angiotensin-aldosterone system is associated with increased oxidative stress and inflammation. Therefore, LTL may be related to circulating biomarkers of the renin-angiotensin-aldosterone system. METHODS AND RESULTS - We evaluated the cross-sectional relations of LTL (dependent variable) to circulating renin and aldosterone concentrations and the renin-to-aldosterone ratio (all logarithmically transformed; independent variables) in 1203 Framingham Study participants (mean age, 59 years; 51% women). We used multivariable linear regression and adjusted for age, blood pressure, hypertension treatment, smoking, diabetes mellitus, body mass index, hormone replacement therapy, serum creatinine, and the urine sodium-to-creatinine ratio. Overall, multivariable-adjusted LTL was inversely related to renin (β coefficient per unit increase, -0.038; P=0.036), directly related to aldosterone (β=0.099; P=0.002), and inversely related to the renin-to-aldosterone ratio (β=-0.049; P=0.003). Relations of LTL to biomarkers were stronger in those with hypertension, although a formal test of interaction was not statistically significant (P=0.20). Individuals with hypertension displayed significant associations of LTL with renin (β=-0.060; P=0.005), aldosterone (β=0.134; P=0.002), and renin-to-aldosterone ratio (β=-0.072; P<0.001). Participants with hypertension who were in the top tertile of the renin-to-aldosterone ratio had LTL that was 182 base pairs shorter relative to those in the lowest tertile. CONCLUSIONS - In our community-based sample, LTL was shorter in individuals with a higher renin-to-aldosterone ratio, especially in participants with hypertension. Additional investigations are warranted to confirm our observations.
KW - Aldosterone
KW - Epidemiology
KW - Hypertension
KW - Oxidative stress
KW - Renin
KW - Telomere
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U2 - 10.1161/CIRCULATIONAHA.107.731794
DO - 10.1161/CIRCULATIONAHA.107.731794
M3 - Article
C2 - 18268147
AN - SCOPUS:41149110120
SN - 0009-7322
VL - 117
SP - 1138
EP - 1144
JO - Circulation
JF - Circulation
IS - 9
ER -