Abstract
The study objective was to examine the association of microtia with maternal intake of folic-acid-containing supplements and obesity. The study data included deliveries from 1997 to 2005 from the National Birth Defects Prevention Study. Non-syndromic cases of microtia were compared to non-malformed, population-based liveborn control infants, by estimating adjusted odds ratios (AORs) and 95% confidence intervals (CIs) from logistic regression models that included maternal race/ethnicity, education, and study site. Maternal obesity was only weakly associated with microtia. Maternal periconceptional intake of folic-acid-containing vitamin supplements reduced the risk for microtia, but only among non-obese women (OR: 0.63; 95% CI: 0.44-0.91). The reduced risk was stronger when analyses were restricted to isolated cases (OR: 0.51; 95% CI: 0.34-0.77), and it was independent of the level of maternal dietary folate intake. Adjusting for maternal race/ethnicity did not reveal alternative interpretations of this association. This analysis suggests that maternal periconceptional intake of folic-acid-containing supplements may provide protection from microtia for non-obese women.
Original language | English (US) |
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Pages (from-to) | 2756-2761 |
Number of pages | 6 |
Journal | American Journal of Medical Genetics, Part A |
Volume | 152 |
Issue number | 11 |
DOIs | |
State | Published - Nov 2010 |
Keywords
- Anotia
- Birth defect
- Ear
- Epidemiology
- Folic acid
- Microtia
- Obesity
- Risk factor
- Vitamin supplements
ASJC Scopus subject areas
- Genetics
- Genetics(clinical)