Association of N-type calcium channel autoimmunity in patients with autoimmune autonomic ganglionopathy

Kurt Kimpinski, Valeria Iodice, Steve Vernino, Paola Sandroni, Phillip A. Low

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The nicotinic acetylcholine receptor (nAChR) antibody directly contributes to the autonomic dysfunction in Autoimmune Autonomic Ganglionopathy (AAG). The pathological mechanism leading to autonomic dysfunction in seronegative AAG is unclear. We evaluated patients with presumed antibody negative AAG (n = 49) to determine whether there was an association with other autoantibodies. Three patients met the clinical criteria and were positive for N-type calcium channel antibodies. All patients had severe autonomic dysfunction characterized by orthostatic hypotension and gastrointestinal involvement. Autonomic testing revealed severe impairment of sudomotor, cardiovagal, and adrenergic domains. These findings raise the possibility that other autoantibodies may contribute to the pathogenesis of AAG.

Original languageEnglish (US)
Pages (from-to)136-139
Number of pages4
JournalAutonomic Neuroscience: Basic and Clinical
Volume150
Issue number1-2
DOIs
StatePublished - Oct 5 2009

Fingerprint

N-Type Calcium Channels
Autoimmunity
Autoantibodies
Antibodies
Orthostatic Hypotension
Nicotinic Receptors
Adrenergic Agents

Keywords

  • Autoimmune ganglionopathy
  • Autonomic failure
  • Calcium channel antibodies

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Endocrine and Autonomic Systems

Cite this

Association of N-type calcium channel autoimmunity in patients with autoimmune autonomic ganglionopathy. / Kimpinski, Kurt; Iodice, Valeria; Vernino, Steve; Sandroni, Paola; Low, Phillip A.

In: Autonomic Neuroscience: Basic and Clinical, Vol. 150, No. 1-2, 05.10.2009, p. 136-139.

Research output: Contribution to journalArticle

Kimpinski, Kurt ; Iodice, Valeria ; Vernino, Steve ; Sandroni, Paola ; Low, Phillip A. / Association of N-type calcium channel autoimmunity in patients with autoimmune autonomic ganglionopathy. In: Autonomic Neuroscience: Basic and Clinical. 2009 ; Vol. 150, No. 1-2. pp. 136-139.
@article{5e8fabf2b14947f98052a4c61c02bcc8,
title = "Association of N-type calcium channel autoimmunity in patients with autoimmune autonomic ganglionopathy",
abstract = "The nicotinic acetylcholine receptor (nAChR) antibody directly contributes to the autonomic dysfunction in Autoimmune Autonomic Ganglionopathy (AAG). The pathological mechanism leading to autonomic dysfunction in seronegative AAG is unclear. We evaluated patients with presumed antibody negative AAG (n = 49) to determine whether there was an association with other autoantibodies. Three patients met the clinical criteria and were positive for N-type calcium channel antibodies. All patients had severe autonomic dysfunction characterized by orthostatic hypotension and gastrointestinal involvement. Autonomic testing revealed severe impairment of sudomotor, cardiovagal, and adrenergic domains. These findings raise the possibility that other autoantibodies may contribute to the pathogenesis of AAG.",
keywords = "Autoimmune ganglionopathy, Autonomic failure, Calcium channel antibodies",
author = "Kurt Kimpinski and Valeria Iodice and Steve Vernino and Paola Sandroni and Low, {Phillip A.}",
year = "2009",
month = "10",
day = "5",
doi = "10.1016/j.autneu.2009.06.002",
language = "English (US)",
volume = "150",
pages = "136--139",
journal = "Autonomic Neuroscience: Basic and Clinical",
issn = "1566-0702",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Association of N-type calcium channel autoimmunity in patients with autoimmune autonomic ganglionopathy

AU - Kimpinski, Kurt

AU - Iodice, Valeria

AU - Vernino, Steve

AU - Sandroni, Paola

AU - Low, Phillip A.

PY - 2009/10/5

Y1 - 2009/10/5

N2 - The nicotinic acetylcholine receptor (nAChR) antibody directly contributes to the autonomic dysfunction in Autoimmune Autonomic Ganglionopathy (AAG). The pathological mechanism leading to autonomic dysfunction in seronegative AAG is unclear. We evaluated patients with presumed antibody negative AAG (n = 49) to determine whether there was an association with other autoantibodies. Three patients met the clinical criteria and were positive for N-type calcium channel antibodies. All patients had severe autonomic dysfunction characterized by orthostatic hypotension and gastrointestinal involvement. Autonomic testing revealed severe impairment of sudomotor, cardiovagal, and adrenergic domains. These findings raise the possibility that other autoantibodies may contribute to the pathogenesis of AAG.

AB - The nicotinic acetylcholine receptor (nAChR) antibody directly contributes to the autonomic dysfunction in Autoimmune Autonomic Ganglionopathy (AAG). The pathological mechanism leading to autonomic dysfunction in seronegative AAG is unclear. We evaluated patients with presumed antibody negative AAG (n = 49) to determine whether there was an association with other autoantibodies. Three patients met the clinical criteria and were positive for N-type calcium channel antibodies. All patients had severe autonomic dysfunction characterized by orthostatic hypotension and gastrointestinal involvement. Autonomic testing revealed severe impairment of sudomotor, cardiovagal, and adrenergic domains. These findings raise the possibility that other autoantibodies may contribute to the pathogenesis of AAG.

KW - Autoimmune ganglionopathy

KW - Autonomic failure

KW - Calcium channel antibodies

UR - http://www.scopus.com/inward/record.url?scp=69349095704&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=69349095704&partnerID=8YFLogxK

U2 - 10.1016/j.autneu.2009.06.002

DO - 10.1016/j.autneu.2009.06.002

M3 - Article

VL - 150

SP - 136

EP - 139

JO - Autonomic Neuroscience: Basic and Clinical

JF - Autonomic Neuroscience: Basic and Clinical

SN - 1566-0702

IS - 1-2

ER -