Association of obesity with pulmonary and nonpulmonary complications of pregnancy in asthmatic women

Israel Hendler, Michael Schatz, Valerija Momirova, Robert Wise, Mark Landon, William Mabie, Roger B. Newman, James Kiley, John C. Hauth, Atef Moawad, Steve N. Caritis, Catherine Y. Spong, Kenneth J. Leveno, Menachem Miodovnik, Paul Meis, Ronald J. Wapner, Richard H. Paul, Michael W. Varner, Mary Jo O'Sullivan, Gary R. ThurnauDeborah L. Conway

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE: To evaluate whether maternal obesity is associated with pulmonary and nonpulmonary pregnancy complications in asthmatic women. METHODS: This is a secondary analysis of the prospective cohort Asthma During Pregnancy Study. Asthma patients were classified as having either mild or moderate to severe disease at the beginning of the study. Rates of pulmonary complications of asthma in asthmatic women and rates of nonpulmonary complications of pregnancy among asthma patients and controls, were compared between obese (body mass index ≥ 30 kg/m2) and nonobese women. RESULTS: Maternal body mass index and pregnancy outcome data were available for 1,699 of 1,812 asthmatic women and for 867 of 881 controls. Of the asthma subjects, 30.7% (521) were obese compared with 25.5% of the controls, P = .006. Obese women, regardless of whether they had asthma, were more likely to undergo cesarean delivery (OR 1.6, 95% confidence interval [CI]1.3-2.0) to develop preeclampsia or gestational hypertension (OR 1.7 95% CI 1.3-2.3) and gestational diabetes (OR 4.2, 95% CI 2.8-6.3). There were no differences in the rates of overall asthma improvement (20.6% compared with 23.6%, P = .36) or deterioration (33.3% compared with 28.8%, P = .20) between obese and nonobese asthma patients. After adjustment for confounding variables, obesity, not asthma, was associated with nonpulmonary complications of pregnancy, and obesity was associated with an increase in asthma exacerbations as well (OR 1.3, 95% CI 1.1-1.7). CONCLUSION: Obesity is associated with an increased risk of asthma exacerbations during pregnancy. The increased rate of nonpulmonary complications of pregnancy in asthma patients is associated with obesity in this population and not with asthma status.

Original languageEnglish (US)
Pages (from-to)77-82
Number of pages6
JournalObstetrics and Gynecology
Volume108
Issue number1
DOIs
StatePublished - Jul 2006

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Pregnancy Complications
Asthma
Obesity
Lung
Confidence Intervals
Body Mass Index
Mothers
Pregnancy
Pregnancy Induced Hypertension
Confounding Factors (Epidemiology)
Gestational Diabetes
Pregnancy Outcome
Pre-Eclampsia
Cohort Studies

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Hendler, I., Schatz, M., Momirova, V., Wise, R., Landon, M., Mabie, W., ... Conway, D. L. (2006). Association of obesity with pulmonary and nonpulmonary complications of pregnancy in asthmatic women. Obstetrics and Gynecology, 108(1), 77-82. https://doi.org/10.1097/01.AOG.0000223180.53113.0f

Association of obesity with pulmonary and nonpulmonary complications of pregnancy in asthmatic women. / Hendler, Israel; Schatz, Michael; Momirova, Valerija; Wise, Robert; Landon, Mark; Mabie, William; Newman, Roger B.; Kiley, James; Hauth, John C.; Moawad, Atef; Caritis, Steve N.; Spong, Catherine Y.; Leveno, Kenneth J.; Miodovnik, Menachem; Meis, Paul; Wapner, Ronald J.; Paul, Richard H.; Varner, Michael W.; O'Sullivan, Mary Jo; Thurnau, Gary R.; Conway, Deborah L.

In: Obstetrics and Gynecology, Vol. 108, No. 1, 07.2006, p. 77-82.

Research output: Contribution to journalArticle

Hendler, I, Schatz, M, Momirova, V, Wise, R, Landon, M, Mabie, W, Newman, RB, Kiley, J, Hauth, JC, Moawad, A, Caritis, SN, Spong, CY, Leveno, KJ, Miodovnik, M, Meis, P, Wapner, RJ, Paul, RH, Varner, MW, O'Sullivan, MJ, Thurnau, GR & Conway, DL 2006, 'Association of obesity with pulmonary and nonpulmonary complications of pregnancy in asthmatic women', Obstetrics and Gynecology, vol. 108, no. 1, pp. 77-82. https://doi.org/10.1097/01.AOG.0000223180.53113.0f
Hendler, Israel ; Schatz, Michael ; Momirova, Valerija ; Wise, Robert ; Landon, Mark ; Mabie, William ; Newman, Roger B. ; Kiley, James ; Hauth, John C. ; Moawad, Atef ; Caritis, Steve N. ; Spong, Catherine Y. ; Leveno, Kenneth J. ; Miodovnik, Menachem ; Meis, Paul ; Wapner, Ronald J. ; Paul, Richard H. ; Varner, Michael W. ; O'Sullivan, Mary Jo ; Thurnau, Gary R. ; Conway, Deborah L. / Association of obesity with pulmonary and nonpulmonary complications of pregnancy in asthmatic women. In: Obstetrics and Gynecology. 2006 ; Vol. 108, No. 1. pp. 77-82.
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abstract = "OBJECTIVE: To evaluate whether maternal obesity is associated with pulmonary and nonpulmonary pregnancy complications in asthmatic women. METHODS: This is a secondary analysis of the prospective cohort Asthma During Pregnancy Study. Asthma patients were classified as having either mild or moderate to severe disease at the beginning of the study. Rates of pulmonary complications of asthma in asthmatic women and rates of nonpulmonary complications of pregnancy among asthma patients and controls, were compared between obese (body mass index ≥ 30 kg/m2) and nonobese women. RESULTS: Maternal body mass index and pregnancy outcome data were available for 1,699 of 1,812 asthmatic women and for 867 of 881 controls. Of the asthma subjects, 30.7{\%} (521) were obese compared with 25.5{\%} of the controls, P = .006. Obese women, regardless of whether they had asthma, were more likely to undergo cesarean delivery (OR 1.6, 95{\%} confidence interval [CI]1.3-2.0) to develop preeclampsia or gestational hypertension (OR 1.7 95{\%} CI 1.3-2.3) and gestational diabetes (OR 4.2, 95{\%} CI 2.8-6.3). There were no differences in the rates of overall asthma improvement (20.6{\%} compared with 23.6{\%}, P = .36) or deterioration (33.3{\%} compared with 28.8{\%}, P = .20) between obese and nonobese asthma patients. After adjustment for confounding variables, obesity, not asthma, was associated with nonpulmonary complications of pregnancy, and obesity was associated with an increase in asthma exacerbations as well (OR 1.3, 95{\%} CI 1.1-1.7). CONCLUSION: Obesity is associated with an increased risk of asthma exacerbations during pregnancy. The increased rate of nonpulmonary complications of pregnancy in asthma patients is associated with obesity in this population and not with asthma status.",
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T1 - Association of obesity with pulmonary and nonpulmonary complications of pregnancy in asthmatic women

AU - Hendler, Israel

AU - Schatz, Michael

AU - Momirova, Valerija

AU - Wise, Robert

AU - Landon, Mark

AU - Mabie, William

AU - Newman, Roger B.

AU - Kiley, James

AU - Hauth, John C.

AU - Moawad, Atef

AU - Caritis, Steve N.

AU - Spong, Catherine Y.

AU - Leveno, Kenneth J.

AU - Miodovnik, Menachem

AU - Meis, Paul

AU - Wapner, Ronald J.

AU - Paul, Richard H.

AU - Varner, Michael W.

AU - O'Sullivan, Mary Jo

AU - Thurnau, Gary R.

AU - Conway, Deborah L.

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N2 - OBJECTIVE: To evaluate whether maternal obesity is associated with pulmonary and nonpulmonary pregnancy complications in asthmatic women. METHODS: This is a secondary analysis of the prospective cohort Asthma During Pregnancy Study. Asthma patients were classified as having either mild or moderate to severe disease at the beginning of the study. Rates of pulmonary complications of asthma in asthmatic women and rates of nonpulmonary complications of pregnancy among asthma patients and controls, were compared between obese (body mass index ≥ 30 kg/m2) and nonobese women. RESULTS: Maternal body mass index and pregnancy outcome data were available for 1,699 of 1,812 asthmatic women and for 867 of 881 controls. Of the asthma subjects, 30.7% (521) were obese compared with 25.5% of the controls, P = .006. Obese women, regardless of whether they had asthma, were more likely to undergo cesarean delivery (OR 1.6, 95% confidence interval [CI]1.3-2.0) to develop preeclampsia or gestational hypertension (OR 1.7 95% CI 1.3-2.3) and gestational diabetes (OR 4.2, 95% CI 2.8-6.3). There were no differences in the rates of overall asthma improvement (20.6% compared with 23.6%, P = .36) or deterioration (33.3% compared with 28.8%, P = .20) between obese and nonobese asthma patients. After adjustment for confounding variables, obesity, not asthma, was associated with nonpulmonary complications of pregnancy, and obesity was associated with an increase in asthma exacerbations as well (OR 1.3, 95% CI 1.1-1.7). CONCLUSION: Obesity is associated with an increased risk of asthma exacerbations during pregnancy. The increased rate of nonpulmonary complications of pregnancy in asthma patients is associated with obesity in this population and not with asthma status.

AB - OBJECTIVE: To evaluate whether maternal obesity is associated with pulmonary and nonpulmonary pregnancy complications in asthmatic women. METHODS: This is a secondary analysis of the prospective cohort Asthma During Pregnancy Study. Asthma patients were classified as having either mild or moderate to severe disease at the beginning of the study. Rates of pulmonary complications of asthma in asthmatic women and rates of nonpulmonary complications of pregnancy among asthma patients and controls, were compared between obese (body mass index ≥ 30 kg/m2) and nonobese women. RESULTS: Maternal body mass index and pregnancy outcome data were available for 1,699 of 1,812 asthmatic women and for 867 of 881 controls. Of the asthma subjects, 30.7% (521) were obese compared with 25.5% of the controls, P = .006. Obese women, regardless of whether they had asthma, were more likely to undergo cesarean delivery (OR 1.6, 95% confidence interval [CI]1.3-2.0) to develop preeclampsia or gestational hypertension (OR 1.7 95% CI 1.3-2.3) and gestational diabetes (OR 4.2, 95% CI 2.8-6.3). There were no differences in the rates of overall asthma improvement (20.6% compared with 23.6%, P = .36) or deterioration (33.3% compared with 28.8%, P = .20) between obese and nonobese asthma patients. After adjustment for confounding variables, obesity, not asthma, was associated with nonpulmonary complications of pregnancy, and obesity was associated with an increase in asthma exacerbations as well (OR 1.3, 95% CI 1.1-1.7). CONCLUSION: Obesity is associated with an increased risk of asthma exacerbations during pregnancy. The increased rate of nonpulmonary complications of pregnancy in asthma patients is associated with obesity in this population and not with asthma status.

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