Association of race and ethnicity with withdrawal symptoms, attrition, opioid use, and side-effects during buprenorphine therapy

E. Sherwood Brown, Carlos Tirado, Abu Minhajuddin, Maureen Hillhouse, Bryon Adinoff, Walter Ling, Geetha Doraimani, Christie Thomas

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Some studies report differences in opioid withdrawal between racial/ethnic groups. However, it is not known if these differences are reflected in differential treatment response. Data from National Institute on Drug Abuse (NIDA) Clinical Trials Network-003 were used to examine racial/ethnic differences before and during stabilization with buprenorphine. At induction, non-Hispanic Caucasians had higher objective and subjective withdrawal scores and greater opioid craving than minority participants. No significant between-group differences were observed on these scales following buprenorphine. Non-Hispanic Caucasians and Hispanics reported more adverse events than African Americans. Although ethnic and racial differences were observed prior to buprenorphine treatment, scores following buprenorphine treatment were similar between groups.

Original languageEnglish (US)
Pages (from-to)106-114
Number of pages9
JournalJournal of Ethnicity in Substance Abuse
Volume9
Issue number2
DOIs
StatePublished - Apr 2010

Fingerprint

Buprenorphine
Substance Withdrawal Syndrome
Caucasian
withdrawal
Opioid Analgesics
ethnicity
drug abuse
stabilization
induction
ethnic group
National Institute on Drug Abuse (U.S.)
Group
minority
event
Therapeutics
Hispanic Americans
Ethnic Groups
African Americans
Clinical Trials
American

Keywords

  • Buprenorphine
  • Ethnicity
  • Opioid
  • Race

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Health(social science)

Cite this

Association of race and ethnicity with withdrawal symptoms, attrition, opioid use, and side-effects during buprenorphine therapy. / Brown, E. Sherwood; Tirado, Carlos; Minhajuddin, Abu; Hillhouse, Maureen; Adinoff, Bryon; Ling, Walter; Doraimani, Geetha; Thomas, Christie.

In: Journal of Ethnicity in Substance Abuse, Vol. 9, No. 2, 04.2010, p. 106-114.

Research output: Contribution to journalArticle

Brown, E. Sherwood ; Tirado, Carlos ; Minhajuddin, Abu ; Hillhouse, Maureen ; Adinoff, Bryon ; Ling, Walter ; Doraimani, Geetha ; Thomas, Christie. / Association of race and ethnicity with withdrawal symptoms, attrition, opioid use, and side-effects during buprenorphine therapy. In: Journal of Ethnicity in Substance Abuse. 2010 ; Vol. 9, No. 2. pp. 106-114.
@article{9fd803bbce9e4e2e922cc4dda8879170,
title = "Association of race and ethnicity with withdrawal symptoms, attrition, opioid use, and side-effects during buprenorphine therapy",
abstract = "Some studies report differences in opioid withdrawal between racial/ethnic groups. However, it is not known if these differences are reflected in differential treatment response. Data from National Institute on Drug Abuse (NIDA) Clinical Trials Network-003 were used to examine racial/ethnic differences before and during stabilization with buprenorphine. At induction, non-Hispanic Caucasians had higher objective and subjective withdrawal scores and greater opioid craving than minority participants. No significant between-group differences were observed on these scales following buprenorphine. Non-Hispanic Caucasians and Hispanics reported more adverse events than African Americans. Although ethnic and racial differences were observed prior to buprenorphine treatment, scores following buprenorphine treatment were similar between groups.",
keywords = "Buprenorphine, Ethnicity, Opioid, Race",
author = "Brown, {E. Sherwood} and Carlos Tirado and Abu Minhajuddin and Maureen Hillhouse and Bryon Adinoff and Walter Ling and Geetha Doraimani and Christie Thomas",
year = "2010",
month = "4",
doi = "10.1080/15332641003772587",
language = "English (US)",
volume = "9",
pages = "106--114",
journal = "Journal of Ethnicity in Substance Abuse",
issn = "1533-2640",
publisher = "Routledge",
number = "2",

}

TY - JOUR

T1 - Association of race and ethnicity with withdrawal symptoms, attrition, opioid use, and side-effects during buprenorphine therapy

AU - Brown, E. Sherwood

AU - Tirado, Carlos

AU - Minhajuddin, Abu

AU - Hillhouse, Maureen

AU - Adinoff, Bryon

AU - Ling, Walter

AU - Doraimani, Geetha

AU - Thomas, Christie

PY - 2010/4

Y1 - 2010/4

N2 - Some studies report differences in opioid withdrawal between racial/ethnic groups. However, it is not known if these differences are reflected in differential treatment response. Data from National Institute on Drug Abuse (NIDA) Clinical Trials Network-003 were used to examine racial/ethnic differences before and during stabilization with buprenorphine. At induction, non-Hispanic Caucasians had higher objective and subjective withdrawal scores and greater opioid craving than minority participants. No significant between-group differences were observed on these scales following buprenorphine. Non-Hispanic Caucasians and Hispanics reported more adverse events than African Americans. Although ethnic and racial differences were observed prior to buprenorphine treatment, scores following buprenorphine treatment were similar between groups.

AB - Some studies report differences in opioid withdrawal between racial/ethnic groups. However, it is not known if these differences are reflected in differential treatment response. Data from National Institute on Drug Abuse (NIDA) Clinical Trials Network-003 were used to examine racial/ethnic differences before and during stabilization with buprenorphine. At induction, non-Hispanic Caucasians had higher objective and subjective withdrawal scores and greater opioid craving than minority participants. No significant between-group differences were observed on these scales following buprenorphine. Non-Hispanic Caucasians and Hispanics reported more adverse events than African Americans. Although ethnic and racial differences were observed prior to buprenorphine treatment, scores following buprenorphine treatment were similar between groups.

KW - Buprenorphine

KW - Ethnicity

KW - Opioid

KW - Race

UR - http://www.scopus.com/inward/record.url?scp=77952989534&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77952989534&partnerID=8YFLogxK

U2 - 10.1080/15332641003772587

DO - 10.1080/15332641003772587

M3 - Article

C2 - 20509084

AN - SCOPUS:77952989534

VL - 9

SP - 106

EP - 114

JO - Journal of Ethnicity in Substance Abuse

JF - Journal of Ethnicity in Substance Abuse

SN - 1533-2640

IS - 2

ER -