Association of race and ethnicity with withdrawal symptoms, attrition, opioid use, and side-effects during buprenorphine therapy

E. Sherwood Brown, Carlos Tirado, Abu Minhajuddin, Maureen Hillhouse, Bryon Adinoff, Walter Ling, Geetha Doraimani, Christie Thomas

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Some studies report differences in opioid withdrawal between racial/ethnic groups. However, it is not known if these differences are reflected in differential treatment response. Data from National Institute on Drug Abuse (NIDA) Clinical Trials Network-003 were used to examine racial/ethnic differences before and during stabilization with buprenorphine. At induction, non-Hispanic Caucasians had higher objective and subjective withdrawal scores and greater opioid craving than minority participants. No significant between-group differences were observed on these scales following buprenorphine. Non-Hispanic Caucasians and Hispanics reported more adverse events than African Americans. Although ethnic and racial differences were observed prior to buprenorphine treatment, scores following buprenorphine treatment were similar between groups.

Original languageEnglish (US)
Pages (from-to)106-114
Number of pages9
JournalJournal of Ethnicity in Substance Abuse
Volume9
Issue number2
DOIs
StatePublished - Apr 1 2010

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Keywords

  • Buprenorphine
  • Ethnicity
  • Opioid
  • Race

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Health(social science)

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