Association of the PURSUIT risk score with predischarge ejection fraction, angiographic severity of coronary artery disease, and mortality in a nonselected, community-based population with non-ST-elevation acute myocardial infarction

Emmanouil S. Brilakis, R. Scott Wright, Stephen L. Kopecky, Nikolaos C. Mavrogiorgos, Guy S. Reeder, Charanjit S. Rihal, Bernard J. Gersh, Brent A. Williams, Ian P. Clements

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: The Platelet Glycoprotein IIb/IIIa in Unstable Angina: Receptor Suppression Using Integrilin Therapy (PURSUIT) risk score was derived from the PURSUIT trial population for 30-day mortality prediction. Methods: The PURSUIT risk score was calculated for 337 consecutive Olmsted County residents with non-ST-elevation acute myocardial infarction admitted to the coronary care unit of our institution from 1988 through 1998. Predischarge ejection fraction (EF) measurement was available for 246 patients (73%). After excluding patients with prior coronary artery bypass graft surgery (n = 42), 219 patients (65%) had coronary angiography within 30 days of admission. Mortality at 30 days was 8.9%. Among 30-day survivors, mortality at 1 year was 7.9%. Results: Mean age was 70 ± 13 years, and 37% of patients were women. Mean predischarge EF was 52% ± 16%. Patients with higher PURSUIT risk score had lower EF (P < .001). Three-vessel (≥70% stenosis in all 3 coronary arteries) or left main (≥50% stenosis) coronary artery disease was present in 60 of 219 patients (27%) who had coronary angiography. Higher PURSUIT risk score was associated with greater likelihood of 3-vesse or left main disease (P < .001). The PURSUIT risk score had very good predictive accuracy for both early (30-day, C-statistic = 0.78) and late (30-day to 1-year, C-statistic = 0.77) mortality. Conclusions: The PURSUIT risk score correlates with EF, angiographic severity of coronary artery disease, and short- and long-term mortality of nonselected patients with non-ST-elevation acute myocardial infarction.

Original languageEnglish (US)
Pages (from-to)811-818
Number of pages8
JournalAmerican Heart Journal
Volume146
Issue number5
DOIs
StatePublished - Nov 2003

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Coronary Artery Disease
Mortality
Population
Coronary Angiography
Pathologic Constriction
Integrin beta3
Coronary Care Units
Platelet Glycoprotein GPIIb-IIIa Complex
Unstable Angina
Non-ST Elevated Myocardial Infarction
Coronary Artery Bypass
Survivors
Coronary Vessels
Transplants

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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Association of the PURSUIT risk score with predischarge ejection fraction, angiographic severity of coronary artery disease, and mortality in a nonselected, community-based population with non-ST-elevation acute myocardial infarction. / Brilakis, Emmanouil S.; Wright, R. Scott; Kopecky, Stephen L.; Mavrogiorgos, Nikolaos C.; Reeder, Guy S.; Rihal, Charanjit S.; Gersh, Bernard J.; Williams, Brent A.; Clements, Ian P.

In: American Heart Journal, Vol. 146, No. 5, 11.2003, p. 811-818.

Research output: Contribution to journalArticle

Brilakis, Emmanouil S. ; Wright, R. Scott ; Kopecky, Stephen L. ; Mavrogiorgos, Nikolaos C. ; Reeder, Guy S. ; Rihal, Charanjit S. ; Gersh, Bernard J. ; Williams, Brent A. ; Clements, Ian P. / Association of the PURSUIT risk score with predischarge ejection fraction, angiographic severity of coronary artery disease, and mortality in a nonselected, community-based population with non-ST-elevation acute myocardial infarction. In: American Heart Journal. 2003 ; Vol. 146, No. 5. pp. 811-818.
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title = "Association of the PURSUIT risk score with predischarge ejection fraction, angiographic severity of coronary artery disease, and mortality in a nonselected, community-based population with non-ST-elevation acute myocardial infarction",
abstract = "Background: The Platelet Glycoprotein IIb/IIIa in Unstable Angina: Receptor Suppression Using Integrilin Therapy (PURSUIT) risk score was derived from the PURSUIT trial population for 30-day mortality prediction. Methods: The PURSUIT risk score was calculated for 337 consecutive Olmsted County residents with non-ST-elevation acute myocardial infarction admitted to the coronary care unit of our institution from 1988 through 1998. Predischarge ejection fraction (EF) measurement was available for 246 patients (73{\%}). After excluding patients with prior coronary artery bypass graft surgery (n = 42), 219 patients (65{\%}) had coronary angiography within 30 days of admission. Mortality at 30 days was 8.9{\%}. Among 30-day survivors, mortality at 1 year was 7.9{\%}. Results: Mean age was 70 ± 13 years, and 37{\%} of patients were women. Mean predischarge EF was 52{\%} ± 16{\%}. Patients with higher PURSUIT risk score had lower EF (P < .001). Three-vessel (≥70{\%} stenosis in all 3 coronary arteries) or left main (≥50{\%} stenosis) coronary artery disease was present in 60 of 219 patients (27{\%}) who had coronary angiography. Higher PURSUIT risk score was associated with greater likelihood of 3-vesse or left main disease (P < .001). The PURSUIT risk score had very good predictive accuracy for both early (30-day, C-statistic = 0.78) and late (30-day to 1-year, C-statistic = 0.77) mortality. Conclusions: The PURSUIT risk score correlates with EF, angiographic severity of coronary artery disease, and short- and long-term mortality of nonselected patients with non-ST-elevation acute myocardial infarction.",
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T1 - Association of the PURSUIT risk score with predischarge ejection fraction, angiographic severity of coronary artery disease, and mortality in a nonselected, community-based population with non-ST-elevation acute myocardial infarction

AU - Brilakis, Emmanouil S.

AU - Wright, R. Scott

AU - Kopecky, Stephen L.

AU - Mavrogiorgos, Nikolaos C.

AU - Reeder, Guy S.

AU - Rihal, Charanjit S.

AU - Gersh, Bernard J.

AU - Williams, Brent A.

AU - Clements, Ian P.

PY - 2003/11

Y1 - 2003/11

N2 - Background: The Platelet Glycoprotein IIb/IIIa in Unstable Angina: Receptor Suppression Using Integrilin Therapy (PURSUIT) risk score was derived from the PURSUIT trial population for 30-day mortality prediction. Methods: The PURSUIT risk score was calculated for 337 consecutive Olmsted County residents with non-ST-elevation acute myocardial infarction admitted to the coronary care unit of our institution from 1988 through 1998. Predischarge ejection fraction (EF) measurement was available for 246 patients (73%). After excluding patients with prior coronary artery bypass graft surgery (n = 42), 219 patients (65%) had coronary angiography within 30 days of admission. Mortality at 30 days was 8.9%. Among 30-day survivors, mortality at 1 year was 7.9%. Results: Mean age was 70 ± 13 years, and 37% of patients were women. Mean predischarge EF was 52% ± 16%. Patients with higher PURSUIT risk score had lower EF (P < .001). Three-vessel (≥70% stenosis in all 3 coronary arteries) or left main (≥50% stenosis) coronary artery disease was present in 60 of 219 patients (27%) who had coronary angiography. Higher PURSUIT risk score was associated with greater likelihood of 3-vesse or left main disease (P < .001). The PURSUIT risk score had very good predictive accuracy for both early (30-day, C-statistic = 0.78) and late (30-day to 1-year, C-statistic = 0.77) mortality. Conclusions: The PURSUIT risk score correlates with EF, angiographic severity of coronary artery disease, and short- and long-term mortality of nonselected patients with non-ST-elevation acute myocardial infarction.

AB - Background: The Platelet Glycoprotein IIb/IIIa in Unstable Angina: Receptor Suppression Using Integrilin Therapy (PURSUIT) risk score was derived from the PURSUIT trial population for 30-day mortality prediction. Methods: The PURSUIT risk score was calculated for 337 consecutive Olmsted County residents with non-ST-elevation acute myocardial infarction admitted to the coronary care unit of our institution from 1988 through 1998. Predischarge ejection fraction (EF) measurement was available for 246 patients (73%). After excluding patients with prior coronary artery bypass graft surgery (n = 42), 219 patients (65%) had coronary angiography within 30 days of admission. Mortality at 30 days was 8.9%. Among 30-day survivors, mortality at 1 year was 7.9%. Results: Mean age was 70 ± 13 years, and 37% of patients were women. Mean predischarge EF was 52% ± 16%. Patients with higher PURSUIT risk score had lower EF (P < .001). Three-vessel (≥70% stenosis in all 3 coronary arteries) or left main (≥50% stenosis) coronary artery disease was present in 60 of 219 patients (27%) who had coronary angiography. Higher PURSUIT risk score was associated with greater likelihood of 3-vesse or left main disease (P < .001). The PURSUIT risk score had very good predictive accuracy for both early (30-day, C-statistic = 0.78) and late (30-day to 1-year, C-statistic = 0.77) mortality. Conclusions: The PURSUIT risk score correlates with EF, angiographic severity of coronary artery disease, and short- and long-term mortality of nonselected patients with non-ST-elevation acute myocardial infarction.

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