Association of Timing of Surgery for Hip Fracture and Patient Outcomes

Gretchen M. Orosz, Jay Magaziner, Edward L. Hannan, R. Sean Morrison, Kenneth Koval, Marvin Gilbert, Maryann McLaughlin, Ethan A. Halm, Jason J. Wang, Ann Litke, Stacey B. Silberzweig, Albert L. Siu

Research output: Contribution to journalArticle

329 Citations (Scopus)

Abstract

Context: Previous studies of surgical timing in patients with hip fracture have yielded conflicting findings on mortality and have not focused on functional outcomes. Objective: To examine the association of timing of surgical repair of hip fracture with function and other outcomes. Design: Prospective cohort study including analyses matching cases of early (≤24 hours) and late (>24 hours) surgery with propensity scores and excluding patients who might not be candidates for early surgery. Setting: Four hospitals in the New York City metropolitan area. Participants A total of 1206 patients aged 50 years or older admitted with hip fracture over 29 months, ending December 1999. Main Outcome Measures: Function (using the Functional Independence Measure), survival, pain, and length of stay (LOS). Results: Of the patients treated with surgery (n = 1178), 33.8% had surgery within 24 hours. Earlier surgery was not associated with improved mortality (hazard ratio, 0. 75; 95% confidence interval [Cl], 0.52-1.08) or improved locomotion (difference of -0.04 points; 95% Cl, -0.49 to 0.39). Earlier surgery was associated with fewer days of severe and very severe pain (difference of -0.22 days; 95% Cl, -0.41 to -0.03) and shorter LOS by 1.94 days (P<.001), but postoperative pain and LOS after surgery did not differ. Analyses with propensity scores yielded similar results. When the cohort included only patients who were medically stable at admission and therefore eligible for early surgery, the results were unchanged except that early surgery was associated with fewer major complications (odds ratio, 0.26; 95% Cl, 0.07-0.95). Conclusions: Early surgery was not associated with improved function or mortality, but it was associated with reduced pain and LOS and probably major complications among patients medically stable at admission. Additional research is needed on whether functional outcomes may be improved. In the meantime, patients with hip fracture who are medically stable should receive early surgery when possible.

Original languageEnglish (US)
Pages (from-to)1738-1743
Number of pages6
JournalJournal of the American Medical Association
Volume291
Issue number14
DOIs
StatePublished - Apr 14 2004

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Hip Fractures
Length of Stay
Propensity Score
Pain
Mortality
Locomotion
Postoperative Pain
Cohort Studies
Odds Ratio
Outcome Assessment (Health Care)
Prospective Studies
Confidence Intervals

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Orosz, G. M., Magaziner, J., Hannan, E. L., Morrison, R. S., Koval, K., Gilbert, M., ... Siu, A. L. (2004). Association of Timing of Surgery for Hip Fracture and Patient Outcomes. Journal of the American Medical Association, 291(14), 1738-1743. https://doi.org/10.1001/jama.291.14.1738

Association of Timing of Surgery for Hip Fracture and Patient Outcomes. / Orosz, Gretchen M.; Magaziner, Jay; Hannan, Edward L.; Morrison, R. Sean; Koval, Kenneth; Gilbert, Marvin; McLaughlin, Maryann; Halm, Ethan A.; Wang, Jason J.; Litke, Ann; Silberzweig, Stacey B.; Siu, Albert L.

In: Journal of the American Medical Association, Vol. 291, No. 14, 14.04.2004, p. 1738-1743.

Research output: Contribution to journalArticle

Orosz, GM, Magaziner, J, Hannan, EL, Morrison, RS, Koval, K, Gilbert, M, McLaughlin, M, Halm, EA, Wang, JJ, Litke, A, Silberzweig, SB & Siu, AL 2004, 'Association of Timing of Surgery for Hip Fracture and Patient Outcomes', Journal of the American Medical Association, vol. 291, no. 14, pp. 1738-1743. https://doi.org/10.1001/jama.291.14.1738
Orosz GM, Magaziner J, Hannan EL, Morrison RS, Koval K, Gilbert M et al. Association of Timing of Surgery for Hip Fracture and Patient Outcomes. Journal of the American Medical Association. 2004 Apr 14;291(14):1738-1743. https://doi.org/10.1001/jama.291.14.1738
Orosz, Gretchen M. ; Magaziner, Jay ; Hannan, Edward L. ; Morrison, R. Sean ; Koval, Kenneth ; Gilbert, Marvin ; McLaughlin, Maryann ; Halm, Ethan A. ; Wang, Jason J. ; Litke, Ann ; Silberzweig, Stacey B. ; Siu, Albert L. / Association of Timing of Surgery for Hip Fracture and Patient Outcomes. In: Journal of the American Medical Association. 2004 ; Vol. 291, No. 14. pp. 1738-1743.
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abstract = "Context: Previous studies of surgical timing in patients with hip fracture have yielded conflicting findings on mortality and have not focused on functional outcomes. Objective: To examine the association of timing of surgical repair of hip fracture with function and other outcomes. Design: Prospective cohort study including analyses matching cases of early (≤24 hours) and late (>24 hours) surgery with propensity scores and excluding patients who might not be candidates for early surgery. Setting: Four hospitals in the New York City metropolitan area. Participants A total of 1206 patients aged 50 years or older admitted with hip fracture over 29 months, ending December 1999. Main Outcome Measures: Function (using the Functional Independence Measure), survival, pain, and length of stay (LOS). Results: Of the patients treated with surgery (n = 1178), 33.8{\%} had surgery within 24 hours. Earlier surgery was not associated with improved mortality (hazard ratio, 0. 75; 95{\%} confidence interval [Cl], 0.52-1.08) or improved locomotion (difference of -0.04 points; 95{\%} Cl, -0.49 to 0.39). Earlier surgery was associated with fewer days of severe and very severe pain (difference of -0.22 days; 95{\%} Cl, -0.41 to -0.03) and shorter LOS by 1.94 days (P<.001), but postoperative pain and LOS after surgery did not differ. Analyses with propensity scores yielded similar results. When the cohort included only patients who were medically stable at admission and therefore eligible for early surgery, the results were unchanged except that early surgery was associated with fewer major complications (odds ratio, 0.26; 95{\%} Cl, 0.07-0.95). Conclusions: Early surgery was not associated with improved function or mortality, but it was associated with reduced pain and LOS and probably major complications among patients medically stable at admission. Additional research is needed on whether functional outcomes may be improved. In the meantime, patients with hip fracture who are medically stable should receive early surgery when possible.",
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AU - Koval, Kenneth

AU - Gilbert, Marvin

AU - McLaughlin, Maryann

AU - Halm, Ethan A.

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