Association of triglyceride-to-high density lipoprotein cholesterol ratio to cardiorespiratory fitness in men

Gloria L Vega, Scott M Grundy, Carolyn E. Barlow, David Leonard, Benjamin L. Willis, Laura F. DeFina, Stephen W. Farrell

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background Both triglyceride-to-high density lipoprotein cholesterol (TG/HDL-C) and cardiorespiratory fitness (CRF) impart risk for all-cause morbidity and mortality independently of conventional risk factors. Objective To determine prevalence and/or incidence of high TG/HDL-C ratio in men with low CRF. Methods Clinical characteristics and CRF were used to determine prevalence of a TG/HDL-C ratio ≥ 3.5 (high ratio) in 13,954 men of the Cooper Center Longitudinal Study. High-ratio conversion was determined in 10,424 men with normal baseline TG/HDL-C ratio. Hazard ratio (HR) of incident high TG/HDL-C was adjusted for age and waist girth. Results Men with low CRF had the highest prevalence of a high TG/HDL-C ratio. In the population with normal TG/HDL-C, age-adjusted HR of incident high TG/HDL-C ratio was 2.77 times higher in men with lowest CRF than in those with highest CRF. Incidence of conversion of normal to high ratio was 5.5% per year in low CRF population, compared with 1.7% in high CRF subjects. Incidence HR was independent of waist girth. Men who converted from normal to high TG/HDL-C ratio during the follow-up period had increased number of metabolic risk factors and a higher prevalence of metabolic syndrome. Men who did not convert to a high TG/HDL-C ratio retained a low prevalence of metabolic syndrome risk factors. Conclusion A high TG/HDL-C ratio is common in men with low CRF. Metabolic syndrome also is common among those with a high ratio.

Original languageEnglish (US)
Pages (from-to)1414-1422.e1
JournalJournal of Clinical Lipidology
Volume10
Issue number6
DOIs
StatePublished - Nov 1 2016

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HDL Cholesterol
Triglycerides
Incidence
Cardiorespiratory Fitness
Population
Longitudinal Studies
Morbidity
Mortality

Keywords

  • Cardiorespiratory fitness
  • TG/HDL-C ratio

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine

Cite this

Association of triglyceride-to-high density lipoprotein cholesterol ratio to cardiorespiratory fitness in men. / Vega, Gloria L; Grundy, Scott M; Barlow, Carolyn E.; Leonard, David; Willis, Benjamin L.; DeFina, Laura F.; Farrell, Stephen W.

In: Journal of Clinical Lipidology, Vol. 10, No. 6, 01.11.2016, p. 1414-1422.e1.

Research output: Contribution to journalArticle

Vega, Gloria L ; Grundy, Scott M ; Barlow, Carolyn E. ; Leonard, David ; Willis, Benjamin L. ; DeFina, Laura F. ; Farrell, Stephen W. / Association of triglyceride-to-high density lipoprotein cholesterol ratio to cardiorespiratory fitness in men. In: Journal of Clinical Lipidology. 2016 ; Vol. 10, No. 6. pp. 1414-1422.e1.
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abstract = "Background Both triglyceride-to-high density lipoprotein cholesterol (TG/HDL-C) and cardiorespiratory fitness (CRF) impart risk for all-cause morbidity and mortality independently of conventional risk factors. Objective To determine prevalence and/or incidence of high TG/HDL-C ratio in men with low CRF. Methods Clinical characteristics and CRF were used to determine prevalence of a TG/HDL-C ratio ≥ 3.5 (high ratio) in 13,954 men of the Cooper Center Longitudinal Study. High-ratio conversion was determined in 10,424 men with normal baseline TG/HDL-C ratio. Hazard ratio (HR) of incident high TG/HDL-C was adjusted for age and waist girth. Results Men with low CRF had the highest prevalence of a high TG/HDL-C ratio. In the population with normal TG/HDL-C, age-adjusted HR of incident high TG/HDL-C ratio was 2.77 times higher in men with lowest CRF than in those with highest CRF. Incidence of conversion of normal to high ratio was 5.5{\%} per year in low CRF population, compared with 1.7{\%} in high CRF subjects. Incidence HR was independent of waist girth. Men who converted from normal to high TG/HDL-C ratio during the follow-up period had increased number of metabolic risk factors and a higher prevalence of metabolic syndrome. Men who did not convert to a high TG/HDL-C ratio retained a low prevalence of metabolic syndrome risk factors. Conclusion A high TG/HDL-C ratio is common in men with low CRF. Metabolic syndrome also is common among those with a high ratio.",
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AU - Vega, Gloria L

AU - Grundy, Scott M

AU - Barlow, Carolyn E.

AU - Leonard, David

AU - Willis, Benjamin L.

AU - DeFina, Laura F.

AU - Farrell, Stephen W.

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N2 - Background Both triglyceride-to-high density lipoprotein cholesterol (TG/HDL-C) and cardiorespiratory fitness (CRF) impart risk for all-cause morbidity and mortality independently of conventional risk factors. Objective To determine prevalence and/or incidence of high TG/HDL-C ratio in men with low CRF. Methods Clinical characteristics and CRF were used to determine prevalence of a TG/HDL-C ratio ≥ 3.5 (high ratio) in 13,954 men of the Cooper Center Longitudinal Study. High-ratio conversion was determined in 10,424 men with normal baseline TG/HDL-C ratio. Hazard ratio (HR) of incident high TG/HDL-C was adjusted for age and waist girth. Results Men with low CRF had the highest prevalence of a high TG/HDL-C ratio. In the population with normal TG/HDL-C, age-adjusted HR of incident high TG/HDL-C ratio was 2.77 times higher in men with lowest CRF than in those with highest CRF. Incidence of conversion of normal to high ratio was 5.5% per year in low CRF population, compared with 1.7% in high CRF subjects. Incidence HR was independent of waist girth. Men who converted from normal to high TG/HDL-C ratio during the follow-up period had increased number of metabolic risk factors and a higher prevalence of metabolic syndrome. Men who did not convert to a high TG/HDL-C ratio retained a low prevalence of metabolic syndrome risk factors. Conclusion A high TG/HDL-C ratio is common in men with low CRF. Metabolic syndrome also is common among those with a high ratio.

AB - Background Both triglyceride-to-high density lipoprotein cholesterol (TG/HDL-C) and cardiorespiratory fitness (CRF) impart risk for all-cause morbidity and mortality independently of conventional risk factors. Objective To determine prevalence and/or incidence of high TG/HDL-C ratio in men with low CRF. Methods Clinical characteristics and CRF were used to determine prevalence of a TG/HDL-C ratio ≥ 3.5 (high ratio) in 13,954 men of the Cooper Center Longitudinal Study. High-ratio conversion was determined in 10,424 men with normal baseline TG/HDL-C ratio. Hazard ratio (HR) of incident high TG/HDL-C was adjusted for age and waist girth. Results Men with low CRF had the highest prevalence of a high TG/HDL-C ratio. In the population with normal TG/HDL-C, age-adjusted HR of incident high TG/HDL-C ratio was 2.77 times higher in men with lowest CRF than in those with highest CRF. Incidence of conversion of normal to high ratio was 5.5% per year in low CRF population, compared with 1.7% in high CRF subjects. Incidence HR was independent of waist girth. Men who converted from normal to high TG/HDL-C ratio during the follow-up period had increased number of metabolic risk factors and a higher prevalence of metabolic syndrome. Men who did not convert to a high TG/HDL-C ratio retained a low prevalence of metabolic syndrome risk factors. Conclusion A high TG/HDL-C ratio is common in men with low CRF. Metabolic syndrome also is common among those with a high ratio.

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KW - TG/HDL-C ratio

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