Association of whole blood viscosity with non-alcoholic fatty liver disease

Xin Yang Yu, Ying Li, Tiemin Liu, Rui Tao Wang

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Abstract

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is an independent risk factor for increased cardiovascular disease. Altered hemorheological parameters have also been shown to play a crucial role in atherogenesis. Moreover, increased viscosity is observed in insulin resistance, metabolic syndrome, hypertension, diabetes, ischemic heart disease, and stroke. A recent study confirmed that whole blood viscosity (WBV) is a predictor of cardiovascular events. AIMS: This study aimed to investigate the association of WBV with NAFLD. METHODS: In this cross-sectional study, we investigated the relationship between WBV and NAFLD in 1329 subjects (962 men and 367 women) in a general health examination. RESULTS: WBV at low shear stress was elevated in patients with NAFLD. In addition, the prevalence of metabolic syndrome and NAFLD increased as WBV quartiles increased both in men and in women. Multiple regression analysis further identified WBV as an independent and significant determinant for NAFLD. CONCLUSIONS: The findings showed that WBV at low shear stress is increased in NAFLD. Moreover, WBV at low shear stress is independently associated with NAFLD even after adjusting other cardiovascular risk factors.

Original languageEnglish (US)
Pages (from-to)335-343
Number of pages9
JournalClinical Hemorheology and Microcirculation
Volume62
Issue number4
DOIs
StatePublished - May 13 2016

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Keywords

  • metabolic syndrome
  • non-alcoholic fatty liver disease
  • Whole blood viscosity

ASJC Scopus subject areas

  • Hematology
  • Physiology
  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

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