Associations between genital tract infections, genital tract inflammation, and cervical cytobrush HIV-1 DNA in US versus Kenyan women

Caroline Mitchell, Jennifer E. Balkus, Jennifer McKernan-Mullin, Susan E. Cohn, Amneris E. Luque, Christina Mwachari, Craig R. Cohen, Robert Coombs, Lisa M. Frenkel, Jane Hitti

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Cervical shedding of HIV-1 DNA may influence HIV-1 sexual transmission. HIV-1 DNA was detected in 250 (80%) of 316 and 207 (79%) of 259 cervical cytobrush specimens from 56 US and 80 Kenyan women, respectively. Plasma HIV-1 RNA concentration was associated with increased HIV-1 DNA shedding among US and Kenyan women. Kenyan women had higher cervicovaginal concentrations of proinflammatory interleukins (IL)-1β, IL-6, IL-8, and anti-inflammatory secretory leukocyte protease inhibitor compared with US women (all P < 0.01). HIV-1 DNA shedding was associated with increased concentrations of IL-1β and IL-6 and lower secretory leukocyte protease inhibitor among US women but not Kenyan women.

Original languageEnglish (US)
Pages (from-to)143-148
Number of pages6
JournalJournal of Acquired Immune Deficiency Syndromes
Volume62
Issue number2
DOIs
StatePublished - Feb 1 2013

Fingerprint

Reproductive Tract Infections
HIV-1
Inflammation
DNA
Secretory Leukocyte Peptidase Inhibitor
Interleukin-1
Interleukin-6
Interleukin-8
Anti-Inflammatory Agents
RNA

Keywords

  • genital cytokines
  • genital HIV-1 shedding
  • genital infections
  • HIV-1 DNA

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Associations between genital tract infections, genital tract inflammation, and cervical cytobrush HIV-1 DNA in US versus Kenyan women. / Mitchell, Caroline; Balkus, Jennifer E.; McKernan-Mullin, Jennifer; Cohn, Susan E.; Luque, Amneris E.; Mwachari, Christina; Cohen, Craig R.; Coombs, Robert; Frenkel, Lisa M.; Hitti, Jane.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 62, No. 2, 01.02.2013, p. 143-148.

Research output: Contribution to journalArticle

Mitchell, Caroline ; Balkus, Jennifer E. ; McKernan-Mullin, Jennifer ; Cohn, Susan E. ; Luque, Amneris E. ; Mwachari, Christina ; Cohen, Craig R. ; Coombs, Robert ; Frenkel, Lisa M. ; Hitti, Jane. / Associations between genital tract infections, genital tract inflammation, and cervical cytobrush HIV-1 DNA in US versus Kenyan women. In: Journal of Acquired Immune Deficiency Syndromes. 2013 ; Vol. 62, No. 2. pp. 143-148.
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