Associations between genital tract infections, genital tract inflammation, and cervical cytobrush HIV-1 DNA in US versus Kenyan women

Caroline Mitchell, Jennifer E. Balkus, Jennifer McKernan-Mullin, Susan E. Cohn, Amneris E. Luque, Christina Mwachari, Craig R. Cohen, Robert Coombs, Lisa M. Frenkel, Jane Hitti

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Cervical shedding of HIV-1 DNA may influence HIV-1 sexual transmission. HIV-1 DNA was detected in 250 (80%) of 316 and 207 (79%) of 259 cervical cytobrush specimens from 56 US and 80 Kenyan women, respectively. Plasma HIV-1 RNA concentration was associated with increased HIV-1 DNA shedding among US and Kenyan women. Kenyan women had higher cervicovaginal concentrations of proinflammatory interleukins (IL)-1β, IL-6, IL-8, and anti-inflammatory secretory leukocyte protease inhibitor compared with US women (all P < 0.01). HIV-1 DNA shedding was associated with increased concentrations of IL-1β and IL-6 and lower secretory leukocyte protease inhibitor among US women but not Kenyan women.

Original languageEnglish (US)
Pages (from-to)143-148
Number of pages6
JournalJournal of Acquired Immune Deficiency Syndromes
Volume62
Issue number2
DOIs
StatePublished - Feb 1 2013

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Keywords

  • HIV-1 DNA
  • genital HIV-1 shedding
  • genital cytokines
  • genital infections

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Mitchell, C., Balkus, J. E., McKernan-Mullin, J., Cohn, S. E., Luque, A. E., Mwachari, C., Cohen, C. R., Coombs, R., Frenkel, L. M., & Hitti, J. (2013). Associations between genital tract infections, genital tract inflammation, and cervical cytobrush HIV-1 DNA in US versus Kenyan women. Journal of Acquired Immune Deficiency Syndromes, 62(2), 143-148. https://doi.org/10.1097/QAI.0b013e318274577d