Abstract
The HLA DR and DQ class II genes are in strong linkage disequilibrium and recombination is quite rare. However, many different DR-DQ haplotypes appear to have developed during evolution, giving rise to a variety of combinations with different distributions in populations. In the present report, 138 subjects from North India were studied for the alleles of HLA-DRB1, DRB3, DRB5, DQB1 and DQA1 loci using PCR-oligotyping. The probable haplotypes were constructed based on two-locus associations observed in this population. A frequent haplotype in this population, DRB1(*)1501-DRB5(*)0101-DQA1(*)0103-DQB1(*)0601, has been reported very rarely in other ethnic groups. Other DR2 haplotypes, like DRB1(*)1502-DRB5(*)0102-DQA1(*)0103-DQB1(*)0601, earlier reported in Caucasians, Chinese and Latin Americans, and DRB1(*)1502-DRB5(*)0102-DQA1(*)0103-DQB1(*)0503, earlier reported in Gypsies, were also observed. A relatively rare haplotype in Caucasians which was earlier reported in Gypsies from the Czech Republic, DRB1(*)1404-DRB3(*)0202-DQA1(*)0101-DQB1(*)0503, was observed frequently in Indians, suggesting the probable migration of Gypsies from India. The results suggest that the North Indian population contains a mixture of Caucasoid, Black and Chinese genes. Similarities with Gypsies and South-East Asian populations suggest the role of ancient migrations from India.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 37-43 |
| Number of pages | 7 |
| Journal | Tissue Antigens |
| Volume | 52 |
| Issue number | 1 |
| State | Published - 1998 |
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Keywords
- Anthropology
- HLA haplotype
- North Indians
ASJC Scopus subject areas
- Immunology
- Cell Biology
Cite this
Associations between HLA class II alleles in a North Indian population. / Rani, R.; Fernandez-Viña, M. A.; Stastny, P.
In: Tissue Antigens, Vol. 52, No. 1, 1998, p. 37-43.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Associations between HLA class II alleles in a North Indian population
AU - Rani, R.
AU - Fernandez-Viña, M. A.
AU - Stastny, P.
PY - 1998
Y1 - 1998
N2 - The HLA DR and DQ class II genes are in strong linkage disequilibrium and recombination is quite rare. However, many different DR-DQ haplotypes appear to have developed during evolution, giving rise to a variety of combinations with different distributions in populations. In the present report, 138 subjects from North India were studied for the alleles of HLA-DRB1, DRB3, DRB5, DQB1 and DQA1 loci using PCR-oligotyping. The probable haplotypes were constructed based on two-locus associations observed in this population. A frequent haplotype in this population, DRB1(*)1501-DRB5(*)0101-DQA1(*)0103-DQB1(*)0601, has been reported very rarely in other ethnic groups. Other DR2 haplotypes, like DRB1(*)1502-DRB5(*)0102-DQA1(*)0103-DQB1(*)0601, earlier reported in Caucasians, Chinese and Latin Americans, and DRB1(*)1502-DRB5(*)0102-DQA1(*)0103-DQB1(*)0503, earlier reported in Gypsies, were also observed. A relatively rare haplotype in Caucasians which was earlier reported in Gypsies from the Czech Republic, DRB1(*)1404-DRB3(*)0202-DQA1(*)0101-DQB1(*)0503, was observed frequently in Indians, suggesting the probable migration of Gypsies from India. The results suggest that the North Indian population contains a mixture of Caucasoid, Black and Chinese genes. Similarities with Gypsies and South-East Asian populations suggest the role of ancient migrations from India.
AB - The HLA DR and DQ class II genes are in strong linkage disequilibrium and recombination is quite rare. However, many different DR-DQ haplotypes appear to have developed during evolution, giving rise to a variety of combinations with different distributions in populations. In the present report, 138 subjects from North India were studied for the alleles of HLA-DRB1, DRB3, DRB5, DQB1 and DQA1 loci using PCR-oligotyping. The probable haplotypes were constructed based on two-locus associations observed in this population. A frequent haplotype in this population, DRB1(*)1501-DRB5(*)0101-DQA1(*)0103-DQB1(*)0601, has been reported very rarely in other ethnic groups. Other DR2 haplotypes, like DRB1(*)1502-DRB5(*)0102-DQA1(*)0103-DQB1(*)0601, earlier reported in Caucasians, Chinese and Latin Americans, and DRB1(*)1502-DRB5(*)0102-DQA1(*)0103-DQB1(*)0503, earlier reported in Gypsies, were also observed. A relatively rare haplotype in Caucasians which was earlier reported in Gypsies from the Czech Republic, DRB1(*)1404-DRB3(*)0202-DQA1(*)0101-DQB1(*)0503, was observed frequently in Indians, suggesting the probable migration of Gypsies from India. The results suggest that the North Indian population contains a mixture of Caucasoid, Black and Chinese genes. Similarities with Gypsies and South-East Asian populations suggest the role of ancient migrations from India.
KW - Anthropology
KW - HLA haplotype
KW - North Indians
UR - http://www.scopus.com/inward/record.url?scp=0031868484&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031868484&partnerID=8YFLogxK
M3 - Article
C2 - 9714472
AN - SCOPUS:0031868484
VL - 52
SP - 37
EP - 43
JO - HLA
JF - HLA
SN - 2059-2302
IS - 1
ER -