Associations between HLA class II alleles in a North Indian population

R. Rani, M. A. Fernandez-Viña, P. Stastny

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

The HLA DR and DQ class II genes are in strong linkage disequilibrium and recombination is quite rare. However, many different DR-DQ haplotypes appear to have developed during evolution, giving rise to a variety of combinations with different distributions in populations. In the present report, 138 subjects from North India were studied for the alleles of HLA-DRB1, DRB3, DRB5, DQB1 and DQA1 loci using PCR-oligotyping. The probable haplotypes were constructed based on two-locus associations observed in this population. A frequent haplotype in this population, DRB1(*)1501-DRB5(*)0101-DQA1(*)0103-DQB1(*)0601, has been reported very rarely in other ethnic groups. Other DR2 haplotypes, like DRB1(*)1502-DRB5(*)0102-DQA1(*)0103-DQB1(*)0601, earlier reported in Caucasians, Chinese and Latin Americans, and DRB1(*)1502-DRB5(*)0102-DQA1(*)0103-DQB1(*)0503, earlier reported in Gypsies, were also observed. A relatively rare haplotype in Caucasians which was earlier reported in Gypsies from the Czech Republic, DRB1(*)1404-DRB3(*)0202-DQA1(*)0101-DQB1(*)0503, was observed frequently in Indians, suggesting the probable migration of Gypsies from India. The results suggest that the North Indian population contains a mixture of Caucasoid, Black and Chinese genes. Similarities with Gypsies and South-East Asian populations suggest the role of ancient migrations from India.

Original languageEnglish (US)
Pages (from-to)37-43
Number of pages7
JournalTissue Antigens
Volume52
Issue number1
StatePublished - 1998

Fingerprint

Roma
Haplotypes
Alleles
India
Population
HLA-DRB3 Chains
HLA-DQ Antigens
HLA-DRB1 Chains
MHC Class II Genes
Czech Republic
Linkage Disequilibrium
HLA-DR Antigens
Ethnic Groups
Genetic Recombination
Demography
Polymerase Chain Reaction
Genes

Keywords

  • Anthropology
  • HLA haplotype
  • North Indians

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

Cite this

Rani, R., Fernandez-Viña, M. A., & Stastny, P. (1998). Associations between HLA class II alleles in a North Indian population. Tissue Antigens, 52(1), 37-43.

Associations between HLA class II alleles in a North Indian population. / Rani, R.; Fernandez-Viña, M. A.; Stastny, P.

In: Tissue Antigens, Vol. 52, No. 1, 1998, p. 37-43.

Research output: Contribution to journalArticle

Rani, R, Fernandez-Viña, MA & Stastny, P 1998, 'Associations between HLA class II alleles in a North Indian population', Tissue Antigens, vol. 52, no. 1, pp. 37-43.
Rani R, Fernandez-Viña MA, Stastny P. Associations between HLA class II alleles in a North Indian population. Tissue Antigens. 1998;52(1):37-43.
Rani, R. ; Fernandez-Viña, M. A. ; Stastny, P. / Associations between HLA class II alleles in a North Indian population. In: Tissue Antigens. 1998 ; Vol. 52, No. 1. pp. 37-43.
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