Associations between soluble CD40 ligand, atherosclerosis risk factors, and subclinical atherosclerosis: Results from the Dallas Heart Study

James A de Lemos, Andreas Zirlik, Uwe Schönbeck, Nerea Varo, Sabina A. Murphy, Amit Khera, Darren K McGuire, Greg Stanek, Hao S. Lo, Rebecca Nuzzo, David A. Morrow, Ronald M Peshock, Peter Libby

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Objectives - The purpose of this study was to evaluate the associations between plasma levels of soluble CD40 ligand (sCD40L), atherosclerosis risk factors, and evidence of subclinical atherosclerosis. Methods and Results - Plasma levels of sCD40L were measured in 2811 subjects from the Dallas Heart Study, a multiethnic population-based cross-sectional study. Electron Beam Computed Tomography measurements of coronary artery calcium (CAC) and MRI measurements of aortic plaque were performed in 2198 and 1965 subjects, respectively. No association was observed between quartiles of sCD40L and age, sex, race, body mass index, diabetes, smoking, creatinine clearance, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, or C-reactive protein. In contrast, weak but statistically significant associations were observed between sCD40L and total cholesterol and triglycerides. The prevalence of detectable CAC (CAC score ≥10) and aortic plaque did not differ across sCD40L quartiles, and individuals with CAC scores <10, ≥10 to 100, >100 to 400, and >400 had similar sCD40L levels. Conclusions - In a large and representative multiethnic population-based sample, sCD40L was not associated with most atherosclerotic risk factors or with subclinical atherosclerosis. These findings suggest that sCD40L will not be useful as a tool to screen for the presence of subclinical atherosclerosis in the population. Further evaluation of this biomarker should focus on settings in which platelet activation is common, such as following acute coronary syndromes or coronary revascularization procedures.

Original languageEnglish (US)
Pages (from-to)2192-2196
Number of pages5
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume25
Issue number10
DOIs
StatePublished - Oct 2005

Fingerprint

CD40 Ligand
Atherosclerosis
Coronary Vessels
Calcium
Population
X Ray Computed Tomography
Platelet Activation
Acute Coronary Syndrome
C-Reactive Protein
LDL Cholesterol
HDL Cholesterol
Creatinine
Triglycerides
Body Mass Index
Cross-Sectional Studies
Biomarkers
Smoking
Cholesterol

Keywords

  • Atherosclerosis
  • CD40
  • Cholesterol
  • Diabetes
  • sCD40 ligand

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Associations between soluble CD40 ligand, atherosclerosis risk factors, and subclinical atherosclerosis : Results from the Dallas Heart Study. / de Lemos, James A; Zirlik, Andreas; Schönbeck, Uwe; Varo, Nerea; Murphy, Sabina A.; Khera, Amit; McGuire, Darren K; Stanek, Greg; Lo, Hao S.; Nuzzo, Rebecca; Morrow, David A.; Peshock, Ronald M; Libby, Peter.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 25, No. 10, 10.2005, p. 2192-2196.

Research output: Contribution to journalArticle

de Lemos, James A ; Zirlik, Andreas ; Schönbeck, Uwe ; Varo, Nerea ; Murphy, Sabina A. ; Khera, Amit ; McGuire, Darren K ; Stanek, Greg ; Lo, Hao S. ; Nuzzo, Rebecca ; Morrow, David A. ; Peshock, Ronald M ; Libby, Peter. / Associations between soluble CD40 ligand, atherosclerosis risk factors, and subclinical atherosclerosis : Results from the Dallas Heart Study. In: Arteriosclerosis, Thrombosis, and Vascular Biology. 2005 ; Vol. 25, No. 10. pp. 2192-2196.
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abstract = "Objectives - The purpose of this study was to evaluate the associations between plasma levels of soluble CD40 ligand (sCD40L), atherosclerosis risk factors, and evidence of subclinical atherosclerosis. Methods and Results - Plasma levels of sCD40L were measured in 2811 subjects from the Dallas Heart Study, a multiethnic population-based cross-sectional study. Electron Beam Computed Tomography measurements of coronary artery calcium (CAC) and MRI measurements of aortic plaque were performed in 2198 and 1965 subjects, respectively. No association was observed between quartiles of sCD40L and age, sex, race, body mass index, diabetes, smoking, creatinine clearance, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, or C-reactive protein. In contrast, weak but statistically significant associations were observed between sCD40L and total cholesterol and triglycerides. The prevalence of detectable CAC (CAC score ≥10) and aortic plaque did not differ across sCD40L quartiles, and individuals with CAC scores <10, ≥10 to 100, >100 to 400, and >400 had similar sCD40L levels. Conclusions - In a large and representative multiethnic population-based sample, sCD40L was not associated with most atherosclerotic risk factors or with subclinical atherosclerosis. These findings suggest that sCD40L will not be useful as a tool to screen for the presence of subclinical atherosclerosis in the population. Further evaluation of this biomarker should focus on settings in which platelet activation is common, such as following acute coronary syndromes or coronary revascularization procedures.",
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T2 - Results from the Dallas Heart Study

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AU - Zirlik, Andreas

AU - Schönbeck, Uwe

AU - Varo, Nerea

AU - Murphy, Sabina A.

AU - Khera, Amit

AU - McGuire, Darren K

AU - Stanek, Greg

AU - Lo, Hao S.

AU - Nuzzo, Rebecca

AU - Morrow, David A.

AU - Peshock, Ronald M

AU - Libby, Peter

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N2 - Objectives - The purpose of this study was to evaluate the associations between plasma levels of soluble CD40 ligand (sCD40L), atherosclerosis risk factors, and evidence of subclinical atherosclerosis. Methods and Results - Plasma levels of sCD40L were measured in 2811 subjects from the Dallas Heart Study, a multiethnic population-based cross-sectional study. Electron Beam Computed Tomography measurements of coronary artery calcium (CAC) and MRI measurements of aortic plaque were performed in 2198 and 1965 subjects, respectively. No association was observed between quartiles of sCD40L and age, sex, race, body mass index, diabetes, smoking, creatinine clearance, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, or C-reactive protein. In contrast, weak but statistically significant associations were observed between sCD40L and total cholesterol and triglycerides. The prevalence of detectable CAC (CAC score ≥10) and aortic plaque did not differ across sCD40L quartiles, and individuals with CAC scores <10, ≥10 to 100, >100 to 400, and >400 had similar sCD40L levels. Conclusions - In a large and representative multiethnic population-based sample, sCD40L was not associated with most atherosclerotic risk factors or with subclinical atherosclerosis. These findings suggest that sCD40L will not be useful as a tool to screen for the presence of subclinical atherosclerosis in the population. Further evaluation of this biomarker should focus on settings in which platelet activation is common, such as following acute coronary syndromes or coronary revascularization procedures.

AB - Objectives - The purpose of this study was to evaluate the associations between plasma levels of soluble CD40 ligand (sCD40L), atherosclerosis risk factors, and evidence of subclinical atherosclerosis. Methods and Results - Plasma levels of sCD40L were measured in 2811 subjects from the Dallas Heart Study, a multiethnic population-based cross-sectional study. Electron Beam Computed Tomography measurements of coronary artery calcium (CAC) and MRI measurements of aortic plaque were performed in 2198 and 1965 subjects, respectively. No association was observed between quartiles of sCD40L and age, sex, race, body mass index, diabetes, smoking, creatinine clearance, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, or C-reactive protein. In contrast, weak but statistically significant associations were observed between sCD40L and total cholesterol and triglycerides. The prevalence of detectable CAC (CAC score ≥10) and aortic plaque did not differ across sCD40L quartiles, and individuals with CAC scores <10, ≥10 to 100, >100 to 400, and >400 had similar sCD40L levels. Conclusions - In a large and representative multiethnic population-based sample, sCD40L was not associated with most atherosclerotic risk factors or with subclinical atherosclerosis. These findings suggest that sCD40L will not be useful as a tool to screen for the presence of subclinical atherosclerosis in the population. Further evaluation of this biomarker should focus on settings in which platelet activation is common, such as following acute coronary syndromes or coronary revascularization procedures.

KW - Atherosclerosis

KW - CD40

KW - Cholesterol

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