TY - JOUR
T1 - Associations of race-ethnicity and history of traumatic brain injury with age at onset of alzheimer’s disease
AU - Chase Bailey, K.
AU - Burmaster, Sandra A.M.S.
AU - Schaffert, Jeff M.S.
AU - Lobue, Christian
AU - Vela, Daniela
AU - Rossetti, Heidi
AU - Munro Cullum, C.
N1 - Publisher Copyright:
© 2020, American Psychiatric Association. All rights reserved.
PY - 2020/6/1
Y1 - 2020/6/1
N2 - Objective: This study examined whether a history of traumatic brain injury (TBI) is associated with age at onset of Alzheimer’s disease (AD) in three racial-ethnic groups. Methods: Data from 7,577 non-Hispanic Caucasian, 792 African American, and 870 Hispanic participants with clinically diagnosed AD were obtained from the National Alzheimer’s Coordinating Center. Participants were categorized by the presence or absence of self-reported remote history of TBI (>1 year before diagnosis of AD) with loss of consciousness (LOC) (TBI+) or no history of TBI with LOC (TBI–). Any group differences in education; sex; APOE ε4 alleles; family history of dementia; or history of depression, stroke, hypertension, hypercholesterolemia, and diabetes were included in analyses of covariance comparing clinician-estimated age at AD symptom onset for the TBI+ and TBI– groups. Results: AD onset occurred 2.3 years earlier for non-Hispanic Caucasians (F=30.49, df=1, 7,572, p<0.001) and 3.4 years earlier for African Americans (F=5.17, df=1, 772, p=0.023) in the TBI+ group. In the Hispanic cohort, females in the TBI+ group had AD onset 5.6 years earlier, compared with females in the TBI– group (F=6.96, df=1, 865, p=0.008); little difference in age at AD onset was observed for Hispanic males with and without a TBI history. Conclusions: A history of TBI with LOC was associated with AD onset 2–3 years earlier in non-Hispanic Caucasians and African Americans and an onset nearly 6 years earlier in Hispanic females; no association was observed in Hispanic males. Further work in underserved populations is needed to un-derstand possible underlying mechanisms for these differences.
AB - Objective: This study examined whether a history of traumatic brain injury (TBI) is associated with age at onset of Alzheimer’s disease (AD) in three racial-ethnic groups. Methods: Data from 7,577 non-Hispanic Caucasian, 792 African American, and 870 Hispanic participants with clinically diagnosed AD were obtained from the National Alzheimer’s Coordinating Center. Participants were categorized by the presence or absence of self-reported remote history of TBI (>1 year before diagnosis of AD) with loss of consciousness (LOC) (TBI+) or no history of TBI with LOC (TBI–). Any group differences in education; sex; APOE ε4 alleles; family history of dementia; or history of depression, stroke, hypertension, hypercholesterolemia, and diabetes were included in analyses of covariance comparing clinician-estimated age at AD symptom onset for the TBI+ and TBI– groups. Results: AD onset occurred 2.3 years earlier for non-Hispanic Caucasians (F=30.49, df=1, 7,572, p<0.001) and 3.4 years earlier for African Americans (F=5.17, df=1, 772, p=0.023) in the TBI+ group. In the Hispanic cohort, females in the TBI+ group had AD onset 5.6 years earlier, compared with females in the TBI– group (F=6.96, df=1, 865, p=0.008); little difference in age at AD onset was observed for Hispanic males with and without a TBI history. Conclusions: A history of TBI with LOC was associated with AD onset 2–3 years earlier in non-Hispanic Caucasians and African Americans and an onset nearly 6 years earlier in Hispanic females; no association was observed in Hispanic males. Further work in underserved populations is needed to un-derstand possible underlying mechanisms for these differences.
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U2 - 10.1176/appi.neuropsych.19010002
DO - 10.1176/appi.neuropsych.19010002
M3 - Article
C2 - 31619118
AN - SCOPUS:85084044879
SN - 0895-0172
VL - 32
SP - 280
EP - 285
JO - Journal of Neuropsychiatry and Clinical Neurosciences
JF - Journal of Neuropsychiatry and Clinical Neurosciences
IS - 3
ER -