Asthma: The Interplay Between Viral Infections and Allergic Diseases

Regina K. Rowe, Michelle A. Gill

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

Respiratory viruses and allergens synergistically contribute to disease pathogenesis in asthma. Potential mechanisms underlying this clinically relevant association are the subject of intense investigation. This review summarizes current knowledge and recent advances in this area, with an emphasis on potential mechanisms involving immunoglobulin E, type I interferon antiviral responses, epithelial factors, and the role of dendritic cells and other antigen-presenting cells in linking viral and allergic inflammatory responses relevant to asthmatic disease.

Original languageEnglish (US)
Pages (from-to)115-127
Number of pages13
JournalImmunology and Allergy Clinics of North America
Volume35
Issue number1
DOIs
StatePublished - Jan 1 2015

Keywords

  • Allergy
  • Asthma
  • Atopy
  • Dendritic cells
  • Immunoglobulin E
  • Rhinovirus
  • Type I interferon
  • Viral infection

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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